about
SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpointThe stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathwayRAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylationFunctional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppressionChk2 phosphorylation of BRCA1 regulates DNA double-strand break repairEnhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cellsInvolvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damageATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to AdaptorAtaxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage.Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylationFunctional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATMTargeted disruption of NBS1 reveals its roles in mouse development and DNA repair.Interaction of FANCD2 and NBS1 in the DNA damage responseBRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damageA role for the Tip60 histone acetyltransferase in the acetylation and activation of ATMThe role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint controlMolecular mechanism of the recruitment of NBS1/hMRE11/hRAD50 complex to DNA double-strand breaks: NBS1 binds to gamma-H2AX through FHA/BRCT domainATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeresPromyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR.DNA lesion-specific co-localization of the Mre11/Rad50/Nbs1 (MRN) complex and replication protein A (RPA) to repair foci.The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A.Karyopherin-alpha2 protein interacts with Chk2 and contributes to its nuclear import.NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse.The role of ATM mutations and 11q deletions in disease progression in chronic lymphocytic leukemia.Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1.The fission yeast Rad32(Mre11)-Rad50-Nbs1 complex acts both upstream and downstream of checkpoint signaling in the S-phase DNA damage checkpointThe Mre11 complex is required for ATM activation and the G2/M checkpointThe MRN complex: coordinating and mediating the response to broken chromosomes.Sp1 facilitates DNA double-strand break repair through a nontranscriptional mechanismNBS1 cooperates with homologous recombination to counteract chromosome breakage during replication.Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.Drosophila ATM and Mre11 are essential for the G2/M checkpoint induced by low-dose irradiation.ATM activation in the presence of oxidative stress.Requirement for NBS1 in the S phase checkpoint response to DNA methylation combined with PARP inhibition.Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres.DNA double-strand break repair by homologous recombination.ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.Identification of the interactors of human nibrin (NBN) and of its 26 kDa and 70 kDa fragments arising from the NBN 657del5 founder mutation.Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility.Effects of heat shock on the Mre11/Rad50/Nbs1 complex in irradiated or unirradiated cells.
P2860
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P2860
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Chk2 activation dependence on Nbs1 after DNA damage
@ast
Chk2 activation dependence on Nbs1 after DNA damage
@en
Chk2 activation dependence on Nbs1 after DNA damage
@en-gb
Chk2 activation dependence on Nbs1 after DNA damage
@nl
type
label
Chk2 activation dependence on Nbs1 after DNA damage
@ast
Chk2 activation dependence on Nbs1 after DNA damage
@en
Chk2 activation dependence on Nbs1 after DNA damage
@en-gb
Chk2 activation dependence on Nbs1 after DNA damage
@nl
prefLabel
Chk2 activation dependence on Nbs1 after DNA damage
@ast
Chk2 activation dependence on Nbs1 after DNA damage
@en
Chk2 activation dependence on Nbs1 after DNA damage
@en-gb
Chk2 activation dependence on Nbs1 after DNA damage
@nl
P2093
P2860
P50
P921
P3181
P1476
Chk2 activation dependence on Nbs1 after DNA damage
@en
P2093
F Miccichè
M Nakanishi
P2860
P304
P3181
P356
10.1128/MCB.21.15.5214-5222.2001
P407
P577
2001-08-01T00:00:00Z