The crystal structure of human transketolase and new insights into its mode of action
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Thiamin diphosphate-dependent enzymes: from enzymology to metabolic regulation, drug design and disease modelsTwisted Schiff base intermediates and substrate locale revise transaldolase mechanismStructure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzymeSub-ångström-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediateA δ38 deletion variant of human transketolase as a model of transketolase-like protein 1 exhibits no enzymatic activityAkt phosphorylation and regulation of transketolase is a nodal point for amino acid control of purine synthesisDiphenyl urea derivatives as inhibitors of transketolase: a structure-based virtual screening.Linking vitamin B1 with cancer cell metabolismA thermostable transketolase evolved for aliphatic aldehyde acceptors.Transketolase is upregulated in metastatic peritoneal implants and promotes ovarian cancer cell proliferation.TKTL1 expression in human malign and benign cell lines.A first immunohistochemistry study of transketolase and transketolase-like 1 expression in canine hyperplastic and neoplastic mammary lesions.A preliminary X-ray study of transketolase from Burkholderia pseudomallei.DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design.Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner.Mechanistic aspects of carotenoid biosynthesis.Engineering stereoselectivity of ThDP-dependent enzymes.DXS as a target for structure-based drug design.Mechanical insights of oxythiamine compound as potent inhibitor for human transketolase-like protein 1 (TKTL1 protein).Targeted proteomics reveals promising biomarkers of disease activity and organ involvement in antineutrophil cytoplasmic antibody-associated vasculitisThiamin Diphosphate Activation in 1-Deoxy-d-xylulose 5-Phosphate Synthase: Insights into the Mechanism and Underlying Intermolecular InteractionsHigh-resolution structures of Lactobacillus salivarius transketolase in the presence and absence of thiamine pyrophosphateA pH-based high-throughput assay for transketolase: fingerprinting of substrate tolerance and quantitative kinetics.Cell cycle regulation of purine synthesis by phosphoribosyl pyrophosphate and inorganic phosphate.Phage Display on the Anti-infective Target 1-Deoxy-d-xylulose-5-phosphate Synthase Leads to an Acceptor-Substrate Competitive Peptidic Inhibitor.The Mesomeric Effect of Thiazolium on non-Kekulé Diradicals in Pichia stipitis Transketolase.Donor Promiscuity of a Thermostable Transketolase by Directed Evolution: Efficient Complementation of 1-Deoxy-d-xylulose-5-phosphate Synthase Activity.Structural and biochemical interrogation on transketolase from Pichia stipitis for new functionality.
P2860
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P2860
The crystal structure of human transketolase and new insights into its mode of action
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The crystal structure of human transketolase and new insights into its mode of action
@ast
The crystal structure of human transketolase and new insights into its mode of action
@en
The crystal structure of human transketolase and new insights into its mode of action
@en-gb
The crystal structure of human transketolase and new insights into its mode of action
@nl
type
label
The crystal structure of human transketolase and new insights into its mode of action
@ast
The crystal structure of human transketolase and new insights into its mode of action
@en
The crystal structure of human transketolase and new insights into its mode of action
@en-gb
The crystal structure of human transketolase and new insights into its mode of action
@nl
altLabel
The Crystal Structure of Human Transketolase and New Insights into Its Mode of Action
@en
prefLabel
The crystal structure of human transketolase and new insights into its mode of action
@ast
The crystal structure of human transketolase and new insights into its mode of action
@en
The crystal structure of human transketolase and new insights into its mode of action
@en-gb
The crystal structure of human transketolase and new insights into its mode of action
@nl
P2093
P2860
P921
P3181
P356
P1476
The crystal structure of human transketolase and new insights into its mode of action
@en
P2093
Christoph Parthier
Johannes Coy
Kai Tittmann
Kathrin Schröder-Tittmann
Lars Mitschke
Stefan Lüdtke
P2860
P304
P3181
P356
10.1074/JBC.M110.149955
P407
P577
2010-10-08T00:00:00Z