Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
about
Modulation of LRP6-mediated Wnt signaling by molecular chaperone MesdAmyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1The structure of MESD45-184 brings light into the mechanism of LDLR family foldingTwo Structural and Functional Domains of MESD Required for Proper Folding and Trafficking of LRP5/6Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt SignalingMutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearanceDkk1 stabilizes Wnt co-receptor LRP6: implication for Wnt ligand-induced LRP6 down-regulation.LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy.Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells.Proteomic plasma membrane profiling reveals an essential role for gp96 in the cell surface expression of LDLR family members, including the LDL receptor and LRP6.Tyrosine-based signal mediates LRP6 receptor endocytosis and desensitization of Wnt/β-catenin pathway signaling.The C-terminal region Mesd peptide mimics full-length Mesd and acts as an inhibitor of Wnt/β-catenin signaling in cancer cells.LRP1 shedding in human brain: roles of ADAM10 and ADAM17.Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model.Structural characterization of the Boca/Mesd maturation factors for LDL-receptor-type β propeller domains.Mesd is a general inhibitor of different Wnt ligands in Wnt/LRP signaling and inhibits PC-3 tumor growth in vivo.Receptor-associated protein interacts with amyloid-beta peptide and promotes its cellular uptake.Physiological inhibitors of Wnt signaling.The Wnt/β-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancer.Role of Wnt Co-Receptor LRP6 in Triple Negative Breast Cancer Cell Migration and Invasion.Cooperative folding and ligand-binding properties of LRP6 beta-propeller domains.Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9.Mesd extrinsically promotes phagocytosis by retinal pigment epithelial cells.Membrane-bound Dickkopf-1 in Foxp3+ regulatory T cells suppresses T-cell-mediated autoimmune colitis.Regulated proteolytic processing of LRP6 results in release of its intracellular domain.
P2860
36a1cc287598942008dc293e63120becbd6691a439eb78111e8afa3e5512bfe45661813d019c95f74512c5a4aae2b910f41157927d42b0bb0455301a460ef0ee224ee28a6078ea275d7bff3889c9f4b84b21d0195d1adefb27f0a7de02801cdf26aa661a644bbcb998d031ecdc465a2f9f148cbcc3b0309a74d03411f5057fcb09da2dff006f8c948bde6c949c7e05a9b07485c1092863b81734ff3286290727aef637e8668ffea56b3deaef45ea7b8f8597b25dc3714b8151196bfe38e53ae678714b5098db0d36f75d5ea3f8640ab9ce2079b4bf22d87be87ba976
P248
Q24304105-01FEC36A-22A5-4126-883B-E6C29344283BQ24672149-F7E348A7-51A2-48A1-B557-1872CC8208EAQ27666956-E1428B45-9989-41FC-862C-36503E6D3983Q27667255-C907FCEA-60D7-4B0C-AEE6-80F906361E4BQ27675070-72F87499-E37F-4DA7-96D4-FB0AD6B124C0Q28593527-FBA0076C-9C87-44F3-9DF8-904D8D5E093BQ33603037-F2B7D6E7-357D-4E57-8F71-94417D0CC0B8Q33740256-B689C37D-2594-4A88-9680-46ECC441B6CBQ33902551-37B42993-554E-465D-AB25-E1559D6DF405Q34146759-CAA871E8-8688-4EBF-AE78-AFD48DC1DB4DQ34283427-BC06940B-FECC-44A1-9DCD-E4A97635F7F8Q34612838-6E9C04D7-C2E7-42AD-B58E-0BFA4790372DQ34976135-DF7CD689-AC88-4F03-BF20-FBD5ACFD7509Q34978900-B04B8E7C-39E5-4EC1-8412-45B67EC8AF85Q34996814-C9F461AA-08D9-4FCC-A69D-144FDE04EA09Q35243349-65C664A7-11D3-4D13-BF44-078BEF24DCB9Q37446156-0DF7FE55-DCCD-4674-B062-D1B9DF01444AQ37845920-1A54F314-14C2-4F00-8C12-8625ACD575EAQ37928570-4F378E9E-115A-42EF-BCE4-7074EEC824F1Q38936102-C4BCE247-5003-46F6-81F0-2CF6AAD7CF0CQ39865463-810B357C-D4F7-4BC5-931E-E8A95262B865Q39889999-B4CE0B43-081F-431E-9ED2-EB70C1C20BB4Q40036256-EC67BA8E-DC12-4B18-B46C-EA8FF92E22D2Q41589465-7546CF55-3FC5-4538-9A5F-20679BA908F8Q48259334-3D60AC6C-A479-4F36-9AB0-39321EC5764B
P2860
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
description
2005 nî lūn-bûn
@nan
2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
@ast
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
@en
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
@en-gb
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
@nl
type
label
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
@ast
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
@en
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
@en-gb
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
@nl
prefLabel
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
@ast
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
@en
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
@en-gb
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
@nl
P2093
P921
P356
P1476
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
@en
P2093
Jianglei Chen
Jianjun Wang
Lynn M McCormick
P304
P356
10.1242/JCS.02651
P407
P577
2005-11-15T00:00:00Z