Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling
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Cancer of the Pancreas: Molecular Pathways and Current Advancement in TreatmentKRAS Mutant Pancreatic Cancer: No Lone Path to an Effective TreatmentGenetics and biology of pancreatic ductal adenocarcinomaK-Ras protein as a drug targetGenomic alterations in pancreatic cancer and their relevance to therapyInducing Oncoprotein Degradation to Improve Targeted Cancer TherapyBeyond BRAF: where next for melanoma therapy?KRAS as a Therapeutic Target50 Years of progress in the systemic therapy of non-small cell lung cancerActivation of protein phosphatase 2A tumor suppressor as potential treatment of pancreatic cancer.A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell InvasionRational design of small molecule inhibitors targeting the Ras GEF, SOS1.Identification of pyrazolopyridazinones as PDEδ inhibitors.Dominant Expression of DCLK1 in Human Pancreatic Cancer Stem Cells Accelerates Tumor Invasion and MetastasisStereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategyIn situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12CPDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinityIdentification of an Atg8-Atg3 protein-protein interaction inhibitor from the medicines for Malaria Venture Malaria Box active in blood and liver stage Plasmodium falciparum parasitesRAS isoforms and mutations in cancer at a glanceA Pan-GTPase Inhibitor as a Molecular ProbePubMedPortable: A Framework for Supporting the Development of Text Mining ApplicationsProgress in Making Ras as a Druggable TargetOpen pipelines for integrated tumor genome profiles reveal differences between pancreatic cancer tumors and cell linesSuppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCKPI3K and cancer: lessons, challenges and opportunitiesTargeting pathways downstream of KRAS in lung adenocarcinoma.Targeted therapies for pancreatic adenocarcinoma: Where do we stand, how far can we go?Comprehensive pharmacological profiling of neurofibromatosis cell lines.Ras Dimer Formation as a New Signaling Mechanism and Potential Cancer Therapeutic Target.Molecular pathways and therapeutic targets in lung cancerMutant KRAS promotes malignant pleural effusion formation.Copper-Catalyzed Electrophilic Amination of Heteroaromatic and Aromatic C-H Bonds via TMPZnCl•LiCl Mediated MetalationALK-rearrangements and testing methods in non-small cell lung cancer: a reviewMst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xLA high-throughput assay for small molecule destabilizers of the KRAS oncoproteinOncogenic KRAS signalling in pancreatic cancer.Change or die: targeting adaptive signaling to kinase inhibition in cancer cells.Smarter drugs emerging in pancreatic cancer therapy.Kras as a key oncogene and therapeutic target in pancreatic cancerGLOBIN-5-dependent O2 responses are regulated by PDL-1/PrBP that targets prenylated soluble guanylate cyclases to dendritic endings
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P2860
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling
description
2013 nî lūn-bûn
@nan
2013 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling
@ast
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling
@en
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling
@en-gb
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling
@nl
type
label
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling
@ast
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling
@en
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling
@en-gb
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling
@nl
prefLabel
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling
@ast
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling
@en
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling
@en-gb
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling
@en
P2093
Anchal Chandra
Björn Papke
Gunther Zimmermann
Maike Hoffmann
Nachiket Vartak
Philippe I H Bastiaens
P2860
P2888
P304
P3181
P356
10.1038/NATURE12205
P407
P577
2013-05-30T00:00:00Z
P5875
P6179
1027695431