The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells
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ADCY5 couples glucose to insulin secretion in human isletsThe mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretionThe mitochondrial calcium uniporter complex: molecular components, structure and physiopathological implicationsPurinergic signalling in endocrine organsStructure and function of the mitochondrial calcium uniporter complexLipotoxicity disrupts incretin-regulated human β cell connectivityThe transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult miceIncretin-modulated beta cell energetics in intact islets of Langerhans.Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cellsEssential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells.The mitochondrial calcium uniporter controls skeletal muscle trophism in vivo.Mitochondrial calcium uniporter MCU supports cytoplasmic Ca2+ oscillations, store-operated Ca2+ entry and Ca2+-dependent gene expression in response to receptor stimulationLKB1 and AMPK differentially regulate pancreatic β-cell identity.Rfx6 maintains the functional identity of adult pancreatic β cells.Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects.The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca²⁺ dynamics and insulin secretion.Frequency-dependent mitochondrial Ca(2+) accumulation regulates ATP synthesis in pancreatic β cells.Oscillations of sub-membrane ATP in glucose-stimulated beta cells depend on negative feedback from Ca(2+).The mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and signal transduction pathways.Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose.Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes.K(ATP) channels and islet hormone secretion: new insights and controversies.Minireview: intraislet regulation of insulin secretion in humans.Glucose-induced inhibition of insulin secretion.The destiny of Ca(2+) released by mitochondria.Mathematical models of electrical activity of the pancreatic β-cell: a physiological review.Beta cell connectivity in pancreatic islets: a type 2 diabetes target?Single-cell imaging tools for brain energy metabolism: a review.Cell cycle-related metabolism and mitochondrial dynamics in a replication-competent pancreatic beta-cell line.Calcium co-regulates oxidative metabolism and ATP synthase-dependent respiration in pancreatic beta cells.Disallowance of Acot7 in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion.The Pancreatic β-Cell: A Bioenergetic Perspective.A new split-GFP-based probe reveals DJ-1 translocation into the mitochondrial matrix to sustain ATP synthesis upon nutrient deprivation.The NCLX-type Na+/Ca2+ Exchanger NCX-9 Is Required for Patterning of Neural Circuits in Caenorhabditis elegans.Genetically Encoded Fluorescent Biosensors to Explore AMPK Signaling and Energy Metabolism.Glucose-stimulated single pancreatic islets sustain increased cytosolic ATP levels during initial Ca2+ influx and subsequent Ca2+ oscillations.Local and regional control of calcium dynamics in the pancreatic islet.Mitochondrial Ca2+ uptake 1 (MICU1) and mitochondrial ca2+ uniporter (MCU) contribute to metabolism-secretion coupling in clonal pancreatic β-cells.New insights into the role of mitochondrial calcium homeostasis in cell migration.The triggering pathway to insulin secretion: Functional similarities and differences between the human and the mouse β cells and their translational relevance.
P2860
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P2860
The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
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2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
The mitochondrial Ca2+ uniport ...... ncreases in pancreatic β-cells
@ast
The mitochondrial Ca2+ uniport ...... ncreases in pancreatic β-cells
@en
The mitochondrial Ca2+ uniport ...... ncreases in pancreatic β-cells
@en-gb
The mitochondrial Ca2+ uniport ...... ncreases in pancreatic β-cells
@nl
type
label
The mitochondrial Ca2+ uniport ...... ncreases in pancreatic β-cells
@ast
The mitochondrial Ca2+ uniport ...... ncreases in pancreatic β-cells
@en
The mitochondrial Ca2+ uniport ...... ncreases in pancreatic β-cells
@en-gb
The mitochondrial Ca2+ uniport ...... ncreases in pancreatic β-cells
@nl
prefLabel
The mitochondrial Ca2+ uniport ...... ncreases in pancreatic β-cells
@ast
The mitochondrial Ca2+ uniport ...... ncreases in pancreatic β-cells
@en
The mitochondrial Ca2+ uniport ...... ncreases in pancreatic β-cells
@en-gb
The mitochondrial Ca2+ uniport ...... ncreases in pancreatic β-cells
@nl
P2093
P2860
P50
P921
P3181
P1433
P1476
The mitochondrial Ca2+ uniport ...... ncreases in pancreatic β-cells
@en
P2093
Francesca Semplici
Guy A Rutter
Israel Sekler
Patrick Gilon
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0039722
P407
P577
2012-01-01T00:00:00Z