A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55 - sprookjes - yvandenbroek - TriplyDB

A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55

A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55

http://www.wikidata.org/entity/Q24294369

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ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation What goes on must come off: phosphatases gate-crash the DNA damage response LB100, a small molecule inhibitor of PP2A with potent chemo- and radio-sensitizing potential PPP2R5C Couples Hepatic Glucose and Lipid Homeostasis The genetics of the p53 pathway, apoptosis and cancer therapy.PP2A: The Wolf in Sheep's Clothing?Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice.Molecular mechanisms of microcystin toxicity in animal cells.Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress The B56gamma3 regulatory subunit of protein phosphatase 2A (PP2A) regulates S phase-specific nuclear accumulation of PP2A and the G1 to S transition.A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia.Germline variation in TP53 regulatory network genes associates with breast cancer survival and treatment outcome.Allele-specific copy number analysis of tumors.PP2A:B56{epsilon}, a substrate of caspase-3, regulates p53-dependent and p53-independent apoptosis during development.p53 post-translational modification: deregulated in tumorigenesis Minichromosome maintenance 2 bound with retroviral Gp70 is localized to cytoplasm and enhances DNA-damage-induced apoptosis.A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins.Dynamic regulation of extracellular signal-regulated kinase (ERK) by protein phosphatase 2A regulatory subunit B56γ1 in nuclei induces cell migration.Functional genetic polymorphisms in PP2A subunit genes confer increased risks of lung cancer in southern and eastern Chinese.Ploidy-Seq: inferring mutational chronology by sequencing polyploid tumor subpopulations Regulation of nuclear-cytoplasmic shuttling and function of Family with sequence similarity 13, member A (Fam13a), by B56-containing PP2As and Akt.Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice.Phosphatases: the new brakes for cancer development?Arlm1 is a male-specific modifier of astrocytoma resistance on mouse Chr 12.HEAT repeat 1 motif is required for B56γ-containing protein phosphatase 2A (B56γ-PP2A) holoenzyme assembly and tumor-suppressive function Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer.Regulation of polo-like kinase 1 by DNA damage and PP2A/B55α Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx.The B56γ3 regulatory subunit-containing protein phosphatase 2A outcompetes Akt to regulate p27KIP1 subcellular localization by selectively dephosphorylating phospho-Thr157 of p27KIP1.Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response.Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway.Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization Differential gene expression profiles of PPP2R5C-siRNA-treated malignant T cells.A genetic variant in a PP2A regulatory subunit encoded by the PPP2R2B gene associates with altered breast cancer risk and recurrence.

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P2860

A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55

http://www.wikidata.org/entity/Q24294369

description

2007 nî lūn-bûn

@nan

2007 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2007 թվականի հունվարին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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A specific PP2A regulatory sub ...... hosphorylation of p53 at Thr55

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A specific PP2A regulatory sub ...... hosphorylation of p53 at Thr55

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A specific PP2A regulatory sub ...... hosphorylation of p53 at Thr55

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A specific PP2A regulatory sub ...... hosphorylation of p53 at Thr55

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A specific PP2A regulatory sub ...... hosphorylation of p53 at Thr55

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A specific PP2A regulatory sub ...... hosphorylation of p53 at Thr55

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A specific PP2A regulatory sub ...... hosphorylation of p53 at Thr55

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A specific PP2A regulatory sub ...... hosphorylation of p53 at Thr55

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A specific PP2A regulatory sub ...... hosphorylation of p53 at Thr55

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A specific PP2A regulatory sub ...... hosphorylation of p53 at Thr55

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A specific PP2A regulatory sub ...... hosphorylation of p53 at Thr55

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SJ.EMBOJ.7601519

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The EMBO Journal

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A specific PP2A regulatory sub ...... hosphorylation of p53 at Thr55

@en

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Geoffrey P Shouse

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Heng-Hong Li

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Landon G Piluso

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Xin Cai

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Xuan Liu

http://www.w3.org/2001/XMLSchema#string

P2860

The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm

Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression

Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen

Surfing the p53 network

Genomic organization and mapping of the gene encoding the PP2A B56gamma regulatory subunit

Identification of specific PP2A complexes involved in human cell transformation

Cyclin G recruits PP2A to dephosphorylate Mdm2

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

Protein phosphatase 2A: a panoply of enzymes.

Protein phosphatase 2A: the Trojan Horse of cellular signaling.

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402-11

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scholarly article

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450003

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10.1038/SJ.EMBOJ.7601519

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2

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26

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6558634

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17245430

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protein phosphatase type 2A complex

Protein phosphatase 2 regulatory subunit Balpha

Protein phosphatase 2 regulatory subunit B'gamma

Protein phosphatase 2 regulatory subunit B'alpha

Tumor protein p53

P932

1783465

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