Site-directed mutagenesis of histidine-13 and histidine-114 of human angiogenin. Alanine derivatives inhibit angiogenin-induced angiogenesis
about
Computational and functional characterization of Angiogenin mutations, and correlation with amyotrophic lateral sclerosisFactor VII central. A novel mutation in the catalytic domain that reduces tissue factor binding, impairs activation by factor Xa, and abolishes amidolytic and coagulant activityActin is a binding protein for angiogeninMolecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution.Crystal structure of human angiogenin reveals the structural basis for its functional divergence from ribonucleaseNuclear translocation of angiogenin in proliferating endothelial cells is essential to its angiogenic activityBinding of phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X-ray crystallographytRNA fragments in human health and diseaseResidues involved in the catalysis, base specificity, and cytotoxicity of ribonuclease from Rana catesbeiana based upon mutagenesis and X-ray crystallographyHigh-resolution crystal structures of ribonuclease A complexed with adenylic and uridylic nucleotide inhibitors. Implications for structure-based design of ribonucleolytic inhibitorsInfluence of naturally-occurring 5â ²-pyrophosphate-linked substituents on the binding of adenylic inhibitors to ribonuclease a: An X-ray crystallographic studyStructural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neuronsCrystal structures of murine angiogenin-2 and -3 - probing ‘structure - function’ relationships amongst angiogenin homologuesCrystal structure of human angiogenin with an engineered loop exhibits conformational flexibility at the functional regions of the moleculeCrystal structure of bovine angiogenin at 1.5-A resolutionAngiogenin interacts with the plasminogen activation system at the cell surface of breast cancer cells to regulate plasmin formation and cell migrationRibonuclease inhibitor: structure and functionStress induces tRNA cleavage by angiogenin in mammalian cellsA combined kinetic and modeling study of the catalytic center subsites of human angiogeninMechanisms of loss of functions of human angiogenin variants implicated in amyotrophic lateral sclerosisRole of glutamine-117 in the ribonucleolytic activity of human angiogenin.Endoribonucleases--enzymes gaining spotlight in mRNA metabolism.The C-terminal region of human angiogenin has a dual role in enzymatic activity.Structural and functional implications of positive selection at the primate angiogenin gene.Genetic selection for peptide inhibitors of angiogenin.Binding of human angiogenin inhibits actin polymerization.Transfer RNA and human diseaseMutational dynamics of murine angiogenin duplicates.Angiogenin: a review of the pathophysiology and potential clinical applications.Emerging role of angiogenin in stress response and cell survival under adverse conditions.A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity.Angiogenin-mediated ribosomal RNA transcription as a molecular target for treatment of head and neck squamous cell carcinoma.Ribonuclease/angiogenin inhibitor 1 regulates stress-induced subcellular localization of angiogenin to control growth and survival.Angiogenin antagonists prevent tumor growth in vivoCompartmentalized, functional role of angiogenin during spotted fever group rickettsia-induced endothelial barrier dysfunction: evidence of possible mediation by host tRNA-derived small noncoding RNAs.Comprehensive in silico mutagenesis highlights functionally important residues in proteins.MicroRNA drop in the bloodstream and microRNA boost in the tumour caused by treatment with ribonuclease A leads to an attenuation of tumour malignancy.Network of long-range concerted chemical shift displacements upon ligand binding to human angiogenin.Loss of a histidine residue at the active site of S-locus ribonuclease is associated with self-compatibility in Lycopersicon peruvianum.A ribonuclease inhibitor expresses anti-angiogenic properties and leads to reduced tumor growth in mice
P2860
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P2860
Site-directed mutagenesis of histidine-13 and histidine-114 of human angiogenin. Alanine derivatives inhibit angiogenin-induced angiogenesis
description
1989 nî lūn-bûn
@nan
1989 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Site-directed mutagenesis of h ...... ngiogenin-induced angiogenesis
@ast
Site-directed mutagenesis of h ...... ngiogenin-induced angiogenesis
@en
Site-directed mutagenesis of h ...... ngiogenin-induced angiogenesis
@en-gb
Site-directed mutagenesis of h ...... ngiogenin-induced angiogenesis
@nl
type
label
Site-directed mutagenesis of h ...... ngiogenin-induced angiogenesis
@ast
Site-directed mutagenesis of h ...... ngiogenin-induced angiogenesis
@en
Site-directed mutagenesis of h ...... ngiogenin-induced angiogenesis
@en-gb
Site-directed mutagenesis of h ...... ngiogenin-induced angiogenesis
@nl
prefLabel
Site-directed mutagenesis of h ...... ngiogenin-induced angiogenesis
@ast
Site-directed mutagenesis of h ...... ngiogenin-induced angiogenesis
@en
Site-directed mutagenesis of h ...... ngiogenin-induced angiogenesis
@en-gb
Site-directed mutagenesis of h ...... ngiogenin-induced angiogenesis
@nl
P356
P1433
P1476
Site-directed mutagenesis of h ...... ngiogenin-induced angiogenesis
@en
P2093
P304
P356
10.1021/BI00444A038
P407
P577
1989-09-05T00:00:00Z