MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs
about
The function, regulation and therapeutic implications of the tumor suppressor protein, PML2-Arachidonoylglycerol enhances platelet formation from human megakaryoblasts.Functional interaction between co-expressed MAGE-A proteinsTargeting the epigenome in malignant pleural mesotheliomahMAGEA2 promotes progression of breast cancer by regulating Akt and Erk1/2 pathways.PML-mediated signaling and its role in cancer stem cells.Requirement of PML SUMO interacting motif for RNF4- or arsenic trioxide-induced degradation of nuclear PML isoforms.The tumor suppressor PML specifically accumulates at RPA/Rad51-containing DNA damage repair foci but is nonessential for DNA damage-induced fibroblast senescence.MAGE-A Cancer/Testis Antigens Inhibit MDM2 Ubiquitylation Function and Promote Increased Levels of MDM4Integrative DNA methylation and gene expression analysis to assess the universality of the CpG island methylator phenotypePML IV/ARF interaction enhances p53 SUMO-1 conjugation, activation, and senescence.New Strategies to Direct Therapeutic Targeting of PML to Treat CancersThe Magea gene cluster regulates male germ cell apoptosis without affecting the fertility in micePML, SUMOylation, and SenescencePML tumour suppression and beyond: therapeutic implications.Oncogenic cancer/testis antigens: prime candidates for immunotherapy.The MAGE protein family and cancer.miR-16 and miR-26a target checkpoint kinases Wee1 and Chk1 in response to p53 activation by genotoxic stress.Analysis of host gene expression changes reveals distinct roles for the cytoplasmic domain of the Epstein-Barr virus receptor/CD21 in B-cell maturation, activation, and initiation of virus infection.Expression and clinical significance of MAGE and NY-ESO-1 cancer-testis antigens in adenoid cystic carcinoma of the head and neckHuman MageB2 Protein Expression Enhances E2F Transcriptional Activity, Cell Proliferation, and Resistance to Ribotoxic StressConsequences of point mutations in melanoma-associated antigen 4 (MAGE-A4) protein: Insights from structural and biophysical studiesMolecular dynamics of the full-length p53 monomer.Simultaneous cytoplasmic and nuclear protein expression of melanoma antigen-A family and NY-ESO-1 cancer-testis antigens represents an independent marker for poor survival in head and neck cancer.C-terminal motifs in promyelocytic leukemia protein isoforms critically regulate PML nuclear body formation.MAGEA1 interacts with FBXW7 and regulates ubiquitin ligase-mediated turnover of NICD1 in breast and ovarian cancer cells.Cancer testis antigen expression in testicular germ cell tumorigenesis.
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P2860
MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs
description
2012 nî lūn-bûn
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2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունիսին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
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2012年論文
@zh-mo
2012年論文
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2012年论文
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MageA2 restrains cellular sene ...... PMLIV/p53 axis at the PML-NBs
@ast
MageA2 restrains cellular sene ...... PMLIV/p53 axis at the PML-NBs
@en
MageA2 restrains cellular sene ...... PMLIV/p53 axis at the PML-NBs
@en-gb
MageA2 restrains cellular sene ...... PMLIV/p53 axis at the PML-NBs
@nl
type
label
MageA2 restrains cellular sene ...... PMLIV/p53 axis at the PML-NBs
@ast
MageA2 restrains cellular sene ...... PMLIV/p53 axis at the PML-NBs
@en
MageA2 restrains cellular sene ...... PMLIV/p53 axis at the PML-NBs
@en-gb
MageA2 restrains cellular sene ...... PMLIV/p53 axis at the PML-NBs
@nl
prefLabel
MageA2 restrains cellular sene ...... PMLIV/p53 axis at the PML-NBs
@ast
MageA2 restrains cellular sene ...... PMLIV/p53 axis at the PML-NBs
@en
MageA2 restrains cellular sene ...... PMLIV/p53 axis at the PML-NBs
@en-gb
MageA2 restrains cellular sene ...... PMLIV/p53 axis at the PML-NBs
@nl
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MageA2 restrains cellular sene ...... PMLIV/p53 axis at the PML-NBs
@en
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10.1038/CDD.2011.173
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2012-06-01T00:00:00Z
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1031075325