Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8)
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The ALS8 protein VAPB interacts with the ER-Golgi recycling protein YIF1A and regulates membrane delivery into dendritesVAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasisElectrostatic interaction between oxysterol-binding protein and VAMP-associated protein A revealed by NMR and mutagenesis studiesCharacterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosisPromotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated proteinFFAT rescues VAPA-mediated inhibition of ER-to-Golgi transport and VAPB-mediated ER aggregationHuman VAP-C negatively regulates hepatitis C virus propagationThere's Something Wrong with my MAM; the ER-Mitochondria Axis and Neurodegenerative DiseasesAutophagy and Neurodegeneration: Insights from a Cultured Cell Model of ALSMolecular motor proteins and amyotrophic lateral sclerosisConverging mechanisms in ALS and FTD: disrupted RNA and protein homeostasisA Drosophila model of ALS: human ALS-associated mutation in VAP33A suggests a dominant negative mechanismAmyotrophic lateral sclerosis-linked mutant VAPB inclusions do not interfere with protein degradation pathways or intracellular transport in a cultured cell modelStructural, stability, dynamic and binding properties of the ALS-causing T46I mutant of the hVAPB MSP domain as revealed by NMR and MD simulationsThe amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality controlAccumulation of wildtype and ALS-linked mutated VAPB impairs activity of the proteasome.Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPaseA Trypanosoma brucei protein required for maintenance of the flagellum attachment zone and flagellar pocket ER domains.Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress.Clinical and genetic diversity of SMN1-negative proximal spinal muscular atrophiesVAMP-associated protein B (VAPB) promotes breast tumor growth by modulation of Akt activity.Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients.A fruitful endeavor: modeling ALS in the fruit flyAmyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria.ALS-Linked P56S-VAPB Mutation Impairs the Formation of Multinuclear Myotube in C2C12 Cells.hVAPB, the causative gene of a heterogeneous group of motor neuron diseases in humans, is functionally interchangeable with its Drosophila homologue DVAP-33A at the neuromuscular junction.Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice.Amyotrophic lateral sclerosis: all roads lead to Rome.Insights into ALS pathomechanisms: from flies to humans.Increased levels of phosphoinositides cause neurodegeneration in a Drosophila model of amyotrophic lateral sclerosisGoodpasture antigen-binding protein is a soluble exportable protein that interacts with type IV collagen. Identification of novel membrane-bound isoformsAmyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons.Gain-of-function mutations in the ALS8 causative gene VAPB have detrimental effects on neurons and muscles.Functional implications of sterol transport by the oxysterol-binding protein gene family.Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disordersStress signaling from the endoplasmic reticulum: A central player in the pathogenesis of amyotrophic lateral sclerosis.Endoplasmic reticulum stress and the ER mitochondrial calcium cycle in amyotrophic lateral sclerosis.Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.RNA-binding proteins associated molecular mechanisms of motor neuron degeneration pathogenesis.
P2860
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P2860
Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8)
description
2006 nî lūn-bûn
@nan
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Characterization of amyotrophi ...... sociated protein B (VAPB/ALS8)
@ast
Characterization of amyotrophi ...... sociated protein B (VAPB/ALS8)
@en
Characterization of amyotrophi ...... sociated protein B (VAPB/ALS8)
@nl
type
label
Characterization of amyotrophi ...... sociated protein B (VAPB/ALS8)
@ast
Characterization of amyotrophi ...... sociated protein B (VAPB/ALS8)
@en
Characterization of amyotrophi ...... sociated protein B (VAPB/ALS8)
@nl
prefLabel
Characterization of amyotrophi ...... sociated protein B (VAPB/ALS8)
@ast
Characterization of amyotrophi ...... sociated protein B (VAPB/ALS8)
@en
Characterization of amyotrophi ...... sociated protein B (VAPB/ALS8)
@nl
P2093
P921
P356
P1476
Characterization of amyotrophi ...... sociated protein B (VAPB/ALS8)
@en
P2093
Ikuo Nishimoto
Kohsuke Kanekura
Masaaki Matsuoka
Sadakazu Aiso
P304
P356
10.1074/JBC.M605049200
P407
P577
2006-10-06T00:00:00Z