Expression of TTK, a novel human protein kinase, is associated with cell proliferation
about
Centriole assembly and the role of Mps1: defensible or dispensable?Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinaseHuman Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplicationHuman Mps1 protein kinase is required for centrosome duplication and normal mitotic progressionProkaryotic expression cloning of a novel human tyrosine kinaseHuman MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochoresThe Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complexLoss of the Greatwall Kinase Weakens the Spindle Assembly CheckpointStructural and mechanistic insights into Mps1 kinase activationScaffold-Focused Virtual Screening: Prospective Application to the Discovery of TTK InhibitorsStructure-Based Design of Orally Bioavailable 1 H -Pyrrolo[3,2- c ]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)The yeast CDC37 gene interacts with MPS1 and is required for proper execution of spindle pole body duplication.Quantitative mass spectrometry analysis reveals similar substrate consensus motif for human Mps1 kinase and Plk1Structural and functional characterization of the protein kinase Mps1 in Arabidopsis thalianaGenome-wide analysis of subependymomas shows underlying chromosomal copy number changes involving chromosomes 6, 7, 8 and 14 in a proportion of cases.Mutational analysis of TTK gene in gastric and colorectal cancers with microsatellite instability.Genome-wide transcriptome profiling of homologous recombination DNA repair.The MPS1 family of protein kinases.VDAC3 and Mps1 negatively regulate ciliogenesis.Cellular abundance of Mps1 and the role of its carboxyl terminal tail in substrate recruitment.MicroRNA-196a is a putative diagnostic biomarker and therapeutic target for laryngeal cancer.Mip1 associates with both the Mps1 kinase and actin, and is required for cell cortex stability and anaphase spindle positioning.A putative N-terminal nuclear export sequence is sufficient for Mps1 nuclear exclusion during interphaseTargeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair ProteinsKey role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells.Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylationMolecular profiling of MPS1 gene silencing in U251 glioma cell lineTTK activates Akt and promotes proliferation and migration of hepatocellular carcinoma cells.Whole-genome duplication increases tumor cell sensitivity to MPS1 inhibition.New alleles of the yeast MPS1 gene reveal multiple requirements in spindle pole body duplicationRegulation of kinetochore recruitment of two essential mitotic spindle checkpoint proteins by Mps1 phosphorylationTTK/hMps1 mediates the p53-dependent postmitotic checkpoint by phosphorylating p53 at Thr18.Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent.A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling.In silico analysis of combinatorial microRNA activity reveals target genes and pathways associated with breast cancer metastasis.Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosisIntroduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N-neopentyl
P2860
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P2860
Expression of TTK, a novel human protein kinase, is associated with cell proliferation
description
1992 nî lūn-bûn
@nan
1992 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Expression of TTK, a novel human protein kinase, is associated with cell proliferation
@ast
Expression of TTK, a novel human protein kinase, is associated with cell proliferation
@en
Expression of TTK, a novel human protein kinase, is associated with cell proliferation
@en-gb
Expression of TTK, a novel human protein kinase, is associated with cell proliferation
@nl
type
label
Expression of TTK, a novel human protein kinase, is associated with cell proliferation
@ast
Expression of TTK, a novel human protein kinase, is associated with cell proliferation
@en
Expression of TTK, a novel human protein kinase, is associated with cell proliferation
@en-gb
Expression of TTK, a novel human protein kinase, is associated with cell proliferation
@nl
prefLabel
Expression of TTK, a novel human protein kinase, is associated with cell proliferation
@ast
Expression of TTK, a novel human protein kinase, is associated with cell proliferation
@en
Expression of TTK, a novel human protein kinase, is associated with cell proliferation
@en-gb
Expression of TTK, a novel human protein kinase, is associated with cell proliferation
@nl
P2093
P3181
P1476
Expression of TTK, a novel human protein kinase, is associated with cell proliferation
@en
P2093
A Amendola
A M Rodricks
R Schmandt
S Campbell
P304
P3181
P407
P577
1992-08-05T00:00:00Z