Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation
about
Anthrax toxin receptor 1/tumor endothelium marker 8 mediates cell spreading by coupling extracellular ligands to the actin cytoskeletonReceptor-specific requirements for anthrax toxin delivery into cellsA model of anthrax toxin lethal factor bound to protective antigen.Onset of anthrax toxin pore formationAnthrax vaccine design: strategies to achieve comprehensive protection against spore, bacillus, and toxinRoles of Anthrax Toxin Receptor 2 in Anthrax Toxin Membrane Insertion and Pore FormationMass Spectrometric Detection of Bacterial Protein Toxins and Their Enzymatic ActivityAnthrax prophylaxis: recent advances and future directionsObstructing toxin pathways by targeted pore blockageCellular and physiological effects of anthrax exotoxin and its relevance to disease.Ratcheting up protein translocation with anthrax toxinAtomic structure of anthrax protective antigen pore elucidates toxin translocationThe Protective Antigen Component of Anthrax Toxin Forms Functional Octameric ComplexesDomain 4 of the anthrax protective antigen maintains structure and binding to the host receptor CMG2 at low pHThe Structure of Tumor Endothelial Marker 8 (TEM8) Extracellular Domain and Implications for Its Receptor Function for Recognizing Anthrax ToxinEvidence That Histidine Protonation of Receptor-Bound Anthrax Protective Antigen Is a Trigger for Pore FormationStructural basis for the unfolding of anthrax lethal factor by protective antigen oligomerspH effects on binding between the anthrax protective antigen and the host cellular receptor CMG2Anthrax toxin protective antigen integrates poly- -D-glutamate and pH signals to sense the optimal environment for channel formationHow to Change the Oligomeric State of a Circular Protein Assembly: Switch from 11-Subunit to 12-Subunit TRAP Suggests a General MechanismDomain Flexibility Modulates the Heterogeneous Assembly Mechanism of Anthrax Toxin Protective Antigen19 F Nuclear Magnetic Resonance and Crystallographic Studies of 5-Fluorotryptophan-Labeled Anthrax Protective Antigen and Effects of the Receptor on StabilityAnalysis of antibody responses to protective antigen-based anthrax vaccines through use of competitive assaysA viral nanoparticle with dual function as an anthrax antitoxin and vaccineThe Disulfide Bond Cys255-Cys279 in the Immunoglobulin-Like Domain of Anthrax Toxin Receptor 2 Is Required for Membrane Insertion of Anthrax Protective Antigen PoreAnthrax toxin receptor 2-dependent lethal toxin killing in vivoX-ray and Cryo-electron Microscopy Structures of Monalysin Pore-forming Toxin Reveal Multimerization of the Pro-form.Hemolytic lectin CEL-III heptamerizes via a large structural transition from α-helices to a β-barrel during the transmembrane pore formation process.A protective antigen mutation increases the pH threshold of anthrax toxin receptor 2-mediated pore formationMonitoring the kinetics of the pH-driven transition of the anthrax toxin prepore to the pore by biolayer interferometry and surface plasmon resonance.GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro.Solubilization and characterization of the anthrax toxin pore in detergent micellesPreventing voltage-dependent gating of anthrax toxin channels using engineered disulfides.GroEL as a molecular scaffold for structural analysis of the anthrax toxin pore.Anthrax toxin receptor 2 determinants that dictate the pH threshold of toxin pore formationEffects of spontaneous deamidation on the cytotoxic activity of the Bacillus anthracis protective antigen.Divalent metal ion coordination by residue T118 of anthrax toxin receptor 2 is not essential for protective antigen binding.Immunogenicity of Bacillus anthracis protective antigen domains and efficacy of elicited antibody responses depend on host genetic background.Botulinum neurotoxin devoid of receptor binding domain translocates active protease.Disulfide bonds in the ectodomain of anthrax toxin receptor 2 are required for the receptor-bound protective-antigen pore to function.
P2860
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P2860
Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation
description
2004 nî lūn-bûn
@nan
2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Structure of heptameric protec ...... in pH-dependent pore formation
@ast
Structure of heptameric protec ...... in pH-dependent pore formation
@en
Structure of heptameric protec ...... in pH-dependent pore formation
@en-gb
Structure of heptameric protec ...... in pH-dependent pore formation
@nl
type
label
Structure of heptameric protec ...... in pH-dependent pore formation
@ast
Structure of heptameric protec ...... in pH-dependent pore formation
@en
Structure of heptameric protec ...... in pH-dependent pore formation
@en-gb
Structure of heptameric protec ...... in pH-dependent pore formation
@nl
prefLabel
Structure of heptameric protec ...... in pH-dependent pore formation
@ast
Structure of heptameric protec ...... in pH-dependent pore formation
@en
Structure of heptameric protec ...... in pH-dependent pore formation
@en-gb
Structure of heptameric protec ...... in pH-dependent pore formation
@nl
P2093
P2860
P356
P1476
Structure of heptameric protec ...... in pH-dependent pore formation
@en
P2093
D Borden Lacy
Darran J Wigelsworth
Roman A Melnyk
Stephen C Harrison
P2860
P304
P356
10.1073/PNAS.0405405101
P407
P577
2004-09-07T00:00:00Z