B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK - sprookjes - yvandenbroek - TriplyDB

B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK

B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK

http://www.wikidata.org/entity/Q24303557

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Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3.ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response A cell-based high-content screening assay reveals activators and inhibitors of cancer cell invasion Targeting protein serine/threonine phosphatases for drug development The broken "Off" switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillance Protein Phosphatase 2A as a Therapeutic Target in Acute Myeloid Leukemia PP2A: The Wolf in Sheep's Clothing?Differential regulation and properties of MAPKs Ctip2 is a dynamic regulator of epidermal proliferation and differentiation by integrating EGFR and Notch signaling Segregation and crosstalk of D1 receptor-mediated activation of ERK in striatal medium spiny neurons upon acute administration of psychostimulants DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth.Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice.Association of Tat with promoters of PTEN and PP2A subunits is key to transcriptional activation of apoptotic pathways in HIV-infected CD4+ T cells.MAP4K4 is a novel MAPK/ERK pathway regulator required for lung adenocarcinoma maintenance.A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A PP2A-mediated regulation of Ras signaling in G2 is essential for stable quiescence and normal G1 length.Protein kinase C-dependent dephosphorylation of tyrosine hydroxylase requires the B56δ heterotrimeric form of protein phosphatase 2A Inhibition of protein phosphatase 2A (PP2A) prevents Mcl-1 protein dephosphorylation at the Thr-163/Ser-159 phosphodegron, dramatically reducing expression in Mcl-1-amplified lymphoma cells.Molecular determinants for PP2A substrate specificity: charged residues mediate dephosphorylation of tyrosine hydroxylase by the PP2A/B' regulatory subunit A novel interaction between hScrib and PP1γ downregulates ERK signaling and suppresses oncogene-induced cell transformation.Dynamic regulation of extracellular signal-regulated kinase (ERK) by protein phosphatase 2A regulatory subunit B56γ1 in nuclei induces cell migration.Determinants for Substrate Specificity of Protein Phosphatase 2A.IER3 supports KRASG12D-dependent pancreatic cancer development by sustaining ERK1/2 phosphorylation.Retinoic acid modulates interferon-γ production by hepatic natural killer T cells via phosphatase 2A and the extracellular signal-regulated kinase pathway Immediate early response gene X-1, a potential prognostic biomarker in cancers Phosphatases: the new brakes for cancer development?Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit.Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-κB pathways and their target, IEX-1 The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A.HEAT repeat 1 motif is required for B56γ-containing protein phosphatase 2A (B56γ-PP2A) holoenzyme assembly and tumor-suppressive function Protein kinase C isoform ε negatively regulates ADP-induced calcium mobilization and thromboxane generation in platelets.Signalling by protein phosphatases and drug development: a systems-centred view.Overexpression of PP2A inhibitor SET oncoprotein is associated with tumor progression and poor prognosis in human non-small cell lung cancer.The PP2A inhibitor SET regulates natural killer cell IFN-gamma production.Label-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling.PP2A/B56 and GSK3/Ras suppress PKB activity during Dictyostelium chemotaxis.Lewy-like aggregation of α-synuclein reduces protein phosphatase 2A activity in vitro and in vivo.Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway.

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B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK

http://www.wikidata.org/entity/Q24303557

description

2006 nî lūn-bûn

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2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2006 թվականի փետրվարին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

B56-containing PP2A dephosphor ...... y the early gene IEX-1 and ERK

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B56-containing PP2A dephosphor ...... y the early gene IEX-1 and ERK

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B56-containing PP2A dephosphor ...... y the early gene IEX-1 and ERK

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B56-containing PP2A dephosphor ...... y the early gene IEX-1 and ERK

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type

label

B56-containing PP2A dephosphor ...... y the early gene IEX-1 and ERK

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B56-containing PP2A dephosphor ...... y the early gene IEX-1 and ERK

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B56-containing PP2A dephosphor ...... y the early gene IEX-1 and ERK

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B56-containing PP2A dephosphor ...... y the early gene IEX-1 and ERK

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prefLabel

B56-containing PP2A dephosphor ...... y the early gene IEX-1 and ERK

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B56-containing PP2A dephosphor ...... y the early gene IEX-1 and ERK

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B56-containing PP2A dephosphor ...... y the early gene IEX-1 and ERK

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B56-containing PP2A dephosphor ...... y the early gene IEX-1 and ERK

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SJ.EMBOJ.7600980

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The EMBO Journal

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B56-containing PP2A dephosphor ...... y the early gene IEX-1 and ERK

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Claire Letourneux

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Françoise Porteu

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Géraldine Rocher

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P2860

Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens

Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation

The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR

Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit

The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm

Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif.

IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation

A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation

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4

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25

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16456541

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1383561

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