Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice
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The current research status of normal tension glaucomaOligomerization of optineurin and its oxidative stress- or E50K mutation-driven covalent cross-linking: possible relationship with glaucoma pathologyFunctional analysis of optineurin and some of its disease-associated mutantsLoss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamicsMitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degenerationA Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of OptineurinProcessing of optineurin in neuronal cellsMutant WDR36 directly affects axon growth of retinal ganglion cells leading to progressive retinal degeneration in miceM98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cellsOptineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation.Glaucoma: genes, phenotypes, and new directions for therapy.Autophagy in the eye: implications for ocular cell health.E50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy.Protection of retinal ganglion cells and retinal vasculature by Lycium barbarum polysaccharides in a mouse model of acute ocular hypertensionTranslational models of ocular disease.Copy number variations of TBK1 in Australian patients with primary open-angle glaucoma.Copy number variations and primary open-angle glaucoma.Aqueous humor outflow: dynamics and disease.Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitisUsing genetic mouse models to gain insight into glaucoma: Past results and future possibilities.Optineurin: The autophagy connection.Expression profiling of microRNAs in optineurin (E50K) mutant transgenic miceCellular and molecular biology of optineurin.Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins.Primary open-angle glaucoma genes.Molecular genetics in glaucoma.Toward an integrative view of Optineurin functions.Genetics of primary open angle glaucoma.Rab8 binding to immune cell-specific adaptor LAX facilitates formation of trans-Golgi network-proximal CTLA-4 vesicles for surface expression.A critical role of Hrd1 in the regulation of optineurin degradation and aggresome formation.Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Enables Analysis of Glaucomatous Neurodegeneration.MicroRNAs in glaucoma and neurodegenerative diseases.A yeast model of optineurin proteinopathy reveals a unique aggregation pattern associated with cellular toxicity.Major review: Molecular genetics of primary open-angle glaucoma.Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.Overexpressed mutant optineurin(E50K) induces retinal ganglion cells apoptosis via the mitochondrial pathway.Duplication of TBK1 Stimulates Autophagy in iPSC-derived Retinal Cells from a Patient with Normal Tension Glaucoma.Dock3 interaction with a glutamate-receptor NR2D subunit protects neurons from excitotoxicityVisual impairment in an optineurin mouse model of primary open-angle glaucoma.NMDA receptor subunits have different roles in NMDA-induced neurotoxicity in the retina.
P2860
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P2860
Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice
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2010 nî lūn-bûn
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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Overexpression of optineurin E ...... e retinal degeneration in mice
@ast
Overexpression of optineurin E ...... e retinal degeneration in mice
@en
Overexpression of optineurin E ...... e retinal degeneration in mice
@en-gb
Overexpression of optineurin E ...... e retinal degeneration in mice
@nl
type
label
Overexpression of optineurin E ...... e retinal degeneration in mice
@ast
Overexpression of optineurin E ...... e retinal degeneration in mice
@en
Overexpression of optineurin E ...... e retinal degeneration in mice
@en-gb
Overexpression of optineurin E ...... e retinal degeneration in mice
@nl
prefLabel
Overexpression of optineurin E ...... e retinal degeneration in mice
@ast
Overexpression of optineurin E ...... e retinal degeneration in mice
@en
Overexpression of optineurin E ...... e retinal degeneration in mice
@en-gb
Overexpression of optineurin E ...... e retinal degeneration in mice
@nl
P2093
P2860
P3181
P356
P1476
Overexpression of optineurin E ...... e retinal degeneration in mice
@en
P2093
Atsushi Shimazaki
Kazuhide Kawase
Masakazu Akahori
Masaki Sasaoka
Masayoshi Minami
Minoru Obazawa
Naoki Nakaya
Setsuko Noda
Stanislav Tomarev
Takeshi Iwata
P2860
P304
P3181
P356
10.1093/HMG/DDQ146
P407
P577
2010-07-01T00:00:00Z