Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate ends
about
Defective DNA ligation during short-patch single-strand break repair in ataxia oculomotor apraxia 1Structure of an aprataxin–DNA complex with insights into AOA1 neurodegenerative diseaseGenetic interactions between HNT3/Aprataxin and RAD27/FEN1 suggest parallel pathways for 5' end processing during base excision repairDNA repair deficiency in neurodegeneration.Genes and genetic testing in hereditary ataxias.Neurological disorders associated with DNA strand-break processing enzymes.DNA repair mechanisms in dividing and non-dividing cells.Aprataxin localizes to mitochondria and preserves mitochondrial functionComplete APTX deletion in a patient with ataxia with oculomotor apraxia type 1.XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks.The involvement of DNA-damage and -repair defects in neurological dysfunctionDNA damage and repair: relevance to mechanisms of neurodegenerationXRCC1 protects against the lethality of induced oxidative DNA damage in nondividing neural cellsIdentification of a residue critical for the excision of 3'-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family.To live or to die: a matter of processing damaged DNA termini in neurons.Repair of double-strand breaks by end joining.DNA repair abnormalities leading to ataxia: shared neurological phenotypes and risk factors.Chemical Incorporation of Chain-Terminating Nucleoside Analogs as 3'-Blocking DNA Damage and Their Removal by Human ERCC1-XPF Endonuclease.Modulation of DNA base excision repair during neuronal differentiation.SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair.Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage.DNA end-processing enzyme polynucleotide kinase as a potential target in the treatment of cancer.Development of a high-throughput screening platform for DNA 3'-phosphatases and their inhibitors based on a universal molecular beacon and quantitative real-time PCR.
P2860
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P2860
Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate ends
description
2007 nî lūn-bûn
@nan
2007 թուականին հրատարակուած գիտական յօդուած
@hyw
2007 թվականին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
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name
Aprataxin, causative gene prod ...... e and 3'-phosphoglycolate ends
@ast
Aprataxin, causative gene prod ...... e and 3'-phosphoglycolate ends
@en
Aprataxin, causative gene prod ...... e and 3'-phosphoglycolate ends
@en-gb
Aprataxin, causative gene prod ...... e and 3'-phosphoglycolate ends
@nl
type
label
Aprataxin, causative gene prod ...... e and 3'-phosphoglycolate ends
@ast
Aprataxin, causative gene prod ...... e and 3'-phosphoglycolate ends
@en
Aprataxin, causative gene prod ...... e and 3'-phosphoglycolate ends
@en-gb
Aprataxin, causative gene prod ...... e and 3'-phosphoglycolate ends
@nl
prefLabel
Aprataxin, causative gene prod ...... e and 3'-phosphoglycolate ends
@ast
Aprataxin, causative gene prod ...... e and 3'-phosphoglycolate ends
@en
Aprataxin, causative gene prod ...... e and 3'-phosphoglycolate ends
@en-gb
Aprataxin, causative gene prod ...... e and 3'-phosphoglycolate ends
@nl
P2093
P2860
P356
P1476
Aprataxin, causative gene prod ...... e and 3'-phosphoglycolate ends
@en
P2093
Akihide Koyama
Akio Yokoseki
Atsushi Shiga
Hidetoshi Date
Masatoyo Nishizawa
Masayoshi Tada
Shoji Tsuji
Shuichi Igarashi
Tetsuya Takahashi
Yutaka Yoshida
P2860
P304
P356
10.1093/NAR/GKM158
P407
P577
2007-05-22T00:00:00Z