Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity
about
MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascadesUnanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral responseTRIM5 is an innate immune sensor for the retrovirus capsid latticeImmune signaling by RIG-I-like receptorsZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responsesMitochondrially localised MUL1 is a novel modulator of antiviral signalingMAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune responseHijacking of RIG-I signaling proteins into virus-induced cytoplasmic structures correlates with the inhibition of type I interferon responsesThe Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesisMolecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domainsFunction and regulation of retinoic acid-inducible gene-IAccessory Factors of Cytoplasmic Viral RNA Sensors Required for Antiviral Innate Immune ResponseCytosolic Innate Immune Sensing and Signaling upon InfectionRegulation of antiviral innate immune signaling by stress-induced RNA granulesDED or alive: assembly and regulation of the death effector domain complexesNF-κB, the first quarter-century: remarkable progress and outstanding questionsWhen ubiquitin meets NF-κB: a trove for anti-cancer drug developmentThe role of ubiquitylation in immune defence and pathogen evasiondsRNA-activation of TLR3 and RLR signaling: gene induction-dependent and independent effectsPrion-like polymerization as a signaling mechanismIntracellular nucleic acid sensors and autoimmunityInduction and function of type I and III interferon in response to viral infectionRegulation of NF-κB by ubiquitinationCollaboration of Toll-like and RIG-I-like receptors in human dendritic cells: tRIGgering antiviral innate immune responsesRNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune SignalingVisualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-IStructure and Dynamics of the Second CARD of Human RIG-I Provide Mechanistic Insights into Regulation of RIG-I ActivationThe RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signallingCrystal structure of the TRIM25 B30.2 (PRYSPRY) domain: a key component of antiviral signallingStructural basis for the prion-like MAVS filaments in antiviral innate immunityCrystal and solution structure of the human RIG-I SF2 domainStructural basis for ubiquitin-mediated antiviral signal activation by RIG-IViral Evasion Strategies in Type I IFN Signaling - A Summary of Recent DevelopmentsEmerging Roles of Protein Deamidation in Innate Immune SignalingUbiquitin in Influenza Virus Entry and Innate ImmunityRIG-I-like receptor regulation in virus infection and immunityFunctions of the influenza A virus NS1 protein in antiviral defenseLGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signalingOASL-a new player in controlling antiviral innate immunityInfluenza virus activation of the interferon system
P2860
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P2860
Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
Reconstitution of the RIG-I pa ...... itin chains in innate immunity
@ast
Reconstitution of the RIG-I pa ...... itin chains in innate immunity
@en
Reconstitution of the RIG-I pa ...... itin chains in innate immunity
@en-gb
Reconstitution of the RIG-I pa ...... itin chains in innate immunity
@nl
type
label
Reconstitution of the RIG-I pa ...... itin chains in innate immunity
@ast
Reconstitution of the RIG-I pa ...... itin chains in innate immunity
@en
Reconstitution of the RIG-I pa ...... itin chains in innate immunity
@en-gb
Reconstitution of the RIG-I pa ...... itin chains in innate immunity
@nl
prefLabel
Reconstitution of the RIG-I pa ...... itin chains in innate immunity
@ast
Reconstitution of the RIG-I pa ...... itin chains in innate immunity
@en
Reconstitution of the RIG-I pa ...... itin chains in innate immunity
@en-gb
Reconstitution of the RIG-I pa ...... itin chains in innate immunity
@nl
P2093
P2860
P3181
P1433
P1476
Reconstitution of the RIG-I pa ...... itin chains in innate immunity
@en
P2093
Anirban Adhikari
Fajian Hou
Xiang Chen
Xiaomo Jiang
Zhijian J Chen
P2860
P304
P3181
P356
10.1016/J.CELL.2010.03.029
P407
P50
P577
2010-04-16T00:00:00Z