Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family
about
Neuraminidase-1, a subunit of the cell surface elastin receptor, desialylates and functionally inactivates adjacent receptors interacting with the mitogenic growth factors PDGF-BB and IGF-2Mice doubly-deficient in lysosomal hexosaminidase A and neuraminidase 4 show epileptic crises and rapid neuronal lossLysosomal sialidase (neuraminidase-1) is targeted to the cell surface in a multiprotein complex that facilitates elastic fiber assemblyGallus gallus NEU3 sialidase as model to study protein evolution mechanism based on rapid evolving loops.High-throughput substrate specificity studies of sialidases by using chemoenzymatically synthesized sialoside libraries.Regulation of intracellular signaling by extracellular glycan remodeling.Lysosomal multienzyme complex: pros and cons of working togetherNew insights on the sialidase protein family revealed by a phylogenetic analysis in metazoa.Structural basis for substrate specificity of mammalian neuraminidases.Upregulation of sialidase NEU3 in head and neck squamous cell carcinoma associated with lymph node metastasis.Sialic acid metabolism and sialyltransferases: natural functions and applications.Enhanced Cross-Linking of Diazirine-Modified Sialylated Glycoproteins Enabled through Profiling of Sialidase Specificities.Neuraminidase-1 is required for the normal assembly of elastic fibersAberrant expression of sialidase and cancer progression.Developmental change of sialidase neu4 expression in murine brain and its involvement in the regulation of neuronal cell differentiationHeterodimerization of the sialidase NEU1 with the chaperone protective protein/cathepsin A prevents its premature oligomerization.Regulation and pathophysiological implications of UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) as the key enzyme of sialic acid biosynthesis.Influenza neuraminidase: a druggable target for natural products.Sialidase significance for cancer progression.Sialic acids in cancer biology and immunity.Sialidase NEU4 is involved in glioblastoma stem cell survival.Hypomorphic sialidase expression decreases serum cholesterol by downregulation of VLDL production in mice.Membrane sialidase NEU3 is highly expressed in human melanoma cells promoting cell growth with minimal changes in the composition of gangliosides.Role of Neu4L sialidase and its substrate ganglioside GD3 in neuronal apoptosis induced by catechol metabolites.Zanamivir: an influenza virus neuraminidase inhibitor.Evidence for mitochondrial localization of a novel human sialidase (NEU4).Molecular cloning and biochemical characterization of sialidases from zebrafish (Danio rerio).Endogenous PMN sialidase activity exposes activation epitope on CD11b/CD18 which enhances its binding interaction with ICAM-1.Identifying selective inhibitors against the human cytosolic sialidase NEU2 by substrate specificity studies.Human sialidase NEU4 long and short are extrinsic proteins bound to outer mitochondrial membrane and the endoplasmic reticulum, respectively.Novel pH-dependent regulation of human cytosolic sialidase 2 (NEU2) activities by siastatin B and structural prediction of NEU2/siastatin B complex.Synthesis of selective inhibitors against V. cholerae sialidase and human cytosolic sialidase NEU2.Mice deficient in Neu4 sialidase exhibit abnormal ganglioside catabolism and lysosomal storage.Deregulation of sialidases in human normal and tumor tissues.NEU1;4 hydrolyses Neu5Ac from glycoconjugatesNeuraminidase activity mediates IL-6 production by activated lupus-prone mesangial cells.NEU4L sialidase overexpression promotes β-catenin signaling in neuroblastoma cells, enhancing stem-like malignant cell growth.Keeping it trim: roles of neuraminidases in CNS function
P2860
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P2860
Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family
description
2004 nî lūn-bûn
@nan
2004 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մարտին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Molecular cloning and characte ...... he human sialidase gene family
@ast
Molecular cloning and characte ...... he human sialidase gene family
@en
Molecular cloning and characte ...... he human sialidase gene family
@en-gb
Molecular cloning and characte ...... he human sialidase gene family
@nl
type
label
Molecular cloning and characte ...... he human sialidase gene family
@ast
Molecular cloning and characte ...... he human sialidase gene family
@en
Molecular cloning and characte ...... he human sialidase gene family
@en-gb
Molecular cloning and characte ...... he human sialidase gene family
@nl
prefLabel
Molecular cloning and characte ...... he human sialidase gene family
@ast
Molecular cloning and characte ...... he human sialidase gene family
@en
Molecular cloning and characte ...... he human sialidase gene family
@en-gb
Molecular cloning and characte ...... he human sialidase gene family
@nl
P2093
P1433
P1476
Molecular cloning and characte ...... he human sialidase gene family
@en
P2093
A Ballabio
B Venerando
G Tettamanti
G Zanchetti
P304
P356
10.1016/J.YGENO.2003.08.019
P407
P577
2004-03-01T00:00:00Z