Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations
about
Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjectsHepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4alpha/MODY1 geneMolecular physiology of mammalian glucokinaseDissecting diabetes/metabolic disease mechanisms using pluripotent stem cells and genome editing toolsEpisodic hormone secretion: a comparison of the basis of pulsatile secretion of insulin and GnRH.Coexpression of glucose transporters and glucokinase in Xenopus oocytes indicates that both glucose transport and phosphorylation determine glucose utilizationMonogenic diabetes and pregnancyPresent status of clinical deployment of glucokinase activatorsDysregulation of insulin secretion in children with congenital hyperinsulinism due to sulfonylurea receptor mutationsFunctional characterization of MODY2 mutations highlights the importance of the fine-tuning of glucokinase and its role in glucose sensingPancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucoseInhibition of pancreatic beta-cell glucokinase by antisense RNA expression in transgenic mice: mouse strain-dependent alteration of glucose toleranceAnimal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase geneEvidence of diminished glucose stimulation and endoplasmic reticulum function in nonoscillatory pancreatic islets.Opposite clinical phenotypes of glucokinase disease: Description of a novel activating mutation and contiguous inactivating mutations in human glucokinase (GCK) gene.Maturity-onset diabetes of the young (MODY): a new challenge for pediatric diabetologists.Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line.The Genetic Architecture of Diabetes in Pregnancy: Implications for Clinical Practice.Genetic Counseling for Diabetes Mellitus.Genetics of gestational diabetes mellitus and type 2 diabetes.Identification and functional characterisation of novel glucokinase mutations causing maturity-onset diabetes of the young in Slovakia.Serum levels of pancreatic stone protein (PSP)/reg1A as an indicator of beta-cell apoptosis suggest an increased apoptosis rate in hepatocyte nuclear factor 1 alpha (HNF1A-MODY) carriers from the third decade of life onward.Hepatic glucose uptake, gluconeogenesis and the regulation of glycogen synthesis.Molecular diagnostics in monogenic and multifactorial forms of type 2 diabetes.Genetic approaches to the molecular understanding of type 2 diabetes.Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: common genetic variants in GCK and TCF7L2 are associated with fasting and postchallenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes mellitus fromInherited destiny? Genetics and gestational diabetes mellitus.MODY: history, genetics, pathophysiology, and clinical decision making.Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus.Clinical features and treatment of maturity onset diabetes of the young (MODY).Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase.Antenatal diagnosis of fetal genotype determines if maternal hyperglycemia due to a glucokinase mutation requires treatmentAdolescent non-adherence reveals a genetic cause for diabetesMonogenic models: what have the single gene disorders taught us?Niflumic acid-sensitive ion channels play an important role in the induction of glucose-stimulated insulin secretion by cyclic AMP in miceLong-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations (MODY2).Differential expression of genes and changes in glucose metabolism in the liver of liver-specific glucokinase gene knockout mice.Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes.iPSC-derived β cells model diabetes due to glucokinase deficiencyGlucokinase activators in diabetes management.
P2860
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P2860
Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations
description
1994 nî lūn-bûn
@nan
1994 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի մարտին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Insulin secretory abnormalitie ...... a due to glucokinase mutations
@ast
Insulin secretory abnormalitie ...... a due to glucokinase mutations
@en
Insulin secretory abnormalitie ...... a due to glucokinase mutations
@en-gb
Insulin secretory abnormalitie ...... a due to glucokinase mutations
@nl
type
label
Insulin secretory abnormalitie ...... a due to glucokinase mutations
@ast
Insulin secretory abnormalitie ...... a due to glucokinase mutations
@en
Insulin secretory abnormalitie ...... a due to glucokinase mutations
@en-gb
Insulin secretory abnormalitie ...... a due to glucokinase mutations
@nl
prefLabel
Insulin secretory abnormalitie ...... a due to glucokinase mutations
@ast
Insulin secretory abnormalitie ...... a due to glucokinase mutations
@en
Insulin secretory abnormalitie ...... a due to glucokinase mutations
@en-gb
Insulin secretory abnormalitie ...... a due to glucokinase mutations
@nl
P2093
P2860
P921
P356
P1476
Insulin secretory abnormalitie ...... a due to glucokinase mutations
@en
P2093
P2860
P304
P356
10.1172/JCI117064
P407
P577
1994-03-01T00:00:00Z