Mechanism of activation and inhibition of the HER4/ErbB4 kinase
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Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segmentCell signaling by receptor tyrosine kinasesErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylationThe Juxtamembrane Region of the EGF Receptor Functions as an Activation DomainStructural analysis of the catalytically inactive kinase domain of the human EGF receptor 3Comparative Analysis of Mutant Tyrosine Kinase Chemical Rescue † ‡Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF ReceptorStructural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 ProteinThe Nudix Hydrolase CDP-Chase, a CDP-Choline Pyrophosphatase, Is an Asymmetric Dimer with Two Distinct Enzymatic ActivitiesMechanism for activation of mutated epidermal growth factor receptors in lung cancerAnalysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.Towards automated crystallographic structure refinement with phenix.refineThe Under-Appreciated Promiscuity of the Epidermal Growth Factor Receptor FamilyDeciphering the structural basis of eukaryotic protein kinase regulationStructure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions.Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.Molecular systems biology of ErbB1 signaling: bridging the gap through multiscale modeling and high-performance computing.Her4 and Her2/neu tyrosine kinase domains dimerize and activate in a reconstituted in vitro systemCo-conserved features associated with cis regulation of ErbB tyrosine kinases.Atomistic insights into regulatory mechanisms of the HER2 tyrosine kinase domain: a molecular dynamics study.Differential sensitivity of ERBB2 kinase domain mutations towards lapatinibDifferent epidermal growth factor (EGF) receptor ligands show distinct kinetics and biased or partial agonism for homodimer and heterodimer formation.EGFR-mutated lung cancer: a paradigm of molecular oncology.Geldanamycin selectively targets the nascent form of ERBB3 for degradationMultifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancerResiliency and vulnerability in the HER2-HER3 tumorigenic driver.Carboxyl-group footprinting maps the dimerization interface and phosphorylation-induced conformational changes of a membrane-associated tyrosine kinase.Analysis of Somatic Mutations in Cancer: Molecular Mechanisms of Activation in the ErbB Family of Receptor Tyrosine Kinases.A multiscale modeling approach to investigate molecular mechanisms of pseudokinase activation and drug resistance in the HER3/ErbB3 receptor tyrosine kinase signaling networkKinase activator-receiver preference in ErbB heterodimers is determined by intracellular regions and is not coupled to extracellular asymmetry.Can structural features of kinase receptors provide clues on selectivity and inhibition? A molecular modeling studyCatalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.Regulation of the catalytic activity of the EGF receptor.A structural perspective on the regulation of the epidermal growth factor receptor.Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutationsNavigating into the binding pockets of the HER family protein kinases: discovery of novel EGFR inhibitor as antitumor agent.Prognostic value of ERBB4 expression in patients with triple negative breast cancerThe PAKs come of age: Celebrating 18 years of discovery.Structural Basis for the Non-catalytic Functions of Protein Kinases.Collections of simultaneously altered genes as biomarkers of cancer cell drug response
P2860
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P2860
Mechanism of activation and inhibition of the HER4/ErbB4 kinase
description
2008 nî lūn-bûn
@nan
2008 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մարտին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Mechanism of activation and inhibition of the HER4/ErbB4 kinase
@ast
Mechanism of activation and inhibition of the HER4/ErbB4 kinase
@en
Mechanism of activation and inhibition of the HER4/ErbB4 kinase
@en-gb
Mechanism of activation and inhibition of the HER4/ErbB4 kinase
@nl
type
label
Mechanism of activation and inhibition of the HER4/ErbB4 kinase
@ast
Mechanism of activation and inhibition of the HER4/ErbB4 kinase
@en
Mechanism of activation and inhibition of the HER4/ErbB4 kinase
@en-gb
Mechanism of activation and inhibition of the HER4/ErbB4 kinase
@nl
altLabel
Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase
@en
prefLabel
Mechanism of activation and inhibition of the HER4/ErbB4 kinase
@ast
Mechanism of activation and inhibition of the HER4/ErbB4 kinase
@en
Mechanism of activation and inhibition of the HER4/ErbB4 kinase
@en-gb
Mechanism of activation and inhibition of the HER4/ErbB4 kinase
@nl
P2093
P2860
P921
P3181
P1433
P1476
Mechanism of activation and inhibition of the HER4/ErbB4 kinase
@en
P2093
Aruna Sathyamurthy
Ashutosh Pal
Daniel J Leahy
Mary K Tarrant
Philip A Cole
Sudeep Banjade
Sung Hee Choi
William G Bornmann
P2860
P3181
P356
10.1016/J.STR.2007.12.016
P407
P577
2008-03-01T00:00:00Z