Functional defects of a muscle-specific calpain, p94, caused by mutations associated with limb-girdle muscular dystrophy type 2A
about
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calciumCalpain 3 is a rapid-action, unidirectional proteolytic switch central to muscle remodelingAutolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT-MIM interactionMultiple molecular interactions implicate the connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscleSkeletal muscle-specific calpain is an intracellular Na+-dependent proteaseNovel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscleDown-regulation of MyoD by calpain 3 promotes generation of reserve cells in C2C12 myoblastsAntisense RNA-mediated deficiency of the calpain protease, nCL-4, in NIH3T3 cells is associated with neoplastic transformation and tumorigenesis.Calpain is required for the rapid, calcium-dependent repair of wounded plasma membrane.Myogenic stage, sarcomere length, and protease activity modulate localization of muscle-specific calpain.Expression and functional characteristics of calpain 3 isoforms generated through tissue-specific transcriptional and posttranscriptional eventsListeriolysin O-dependent bacterial entry into the cytoplasm is required for calpain activation and interleukin-1 alpha secretion in macrophages infected with Listeria monocytogenesLabCaS: labeling calpain substrate cleavage sites from amino acid sequence using conditional random fields.Calpain cleavage prediction using multiple kernel learning.Stable expression of calpain 3 from a muscle transgene in vivo: immature muscle in transgenic mice suggests a role for calpain 3 in muscle maturation.Calpain 3 is important for muscle regeneration: evidence from patients with limb girdle muscular dystrophies.Genetic aspects of arrhythmias.Comprehensive survey of p94/calpain 3 substrates by comparative proteomics--possible regulation of protein synthesis by p94.Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system.Adverse and beneficial functions of proteolytic enzymes in skeletal muscle. An overview.The N- and C-terminal autolytic fragments of CAPN3/p94/calpain-3 restore proteolytic activity by intermolecular complementation.Calpains as potential anti-cancer targetsAutolytic activation of calpain 3 proteinase is facilitated by calmodulin proteinCalpain chronicle--an enzyme family under multidisciplinary characterizationExtensive scanning of the calpain-3 gene broadens the spectrum of LGMD2A phenotypes.Calpain-3 impairs cell proliferation and stimulates oxidative stress-mediated cell death in melanoma cells.Loss of calpain-3 autocatalytic activity in LGMD2A patients with normal protein expression.Diagnostic immunohistochemistry in neuromuscular disorders.Genome-wide Mechanosensitive MicroRNA (MechanomiR) Screen Uncovers Dysregulation of Their Regulatory Networks in the mdm Mouse Model of Muscular Dystrophy.Loss of calpain 3 proteolytic activity leads to muscular dystrophy and to apoptosis-associated IkappaBalpha/nuclear factor kappaB pathway perturbation in mice.Calpain 3: a key regulator of the sarcomere?Screening of calpain-3 autolytic activity in LGMD muscle: a functional map of CAPN3 gene mutations.Calpain 3, the "gatekeeper" of proper sarcomere assembly, turnover and maintenance.The role of calcium-activated protease calpain in experimental retinal pathology.A review of statistical methods for prediction of proteolytic cleavage.Calpain system and its involvement in myocardial ischemia and reperfusion injury.Calpain research for drug discovery: challenges and potential.Calpain-14 and its association with eosinophilic esophagitis.Calcium-induced cleavage of DNA topoisomerase I involves the cytoplasmic-nuclear shuttling of calpain 2.Mutations in calpain 3 associated with limb girdle muscular dystrophy: analysis by molecular modeling and by mutation in m-calpain.
P2860
00028e803f774dd2767a45084c8f087950a41f9d063ed0f86c5141639d3e2d1c5082efc2d0d227830b1661ef33b32a036879cc7f016b14785a05bc5f4687d27d76393d8510eb7a47ad48e1e7558d66c565e671f52a0a32708d4d3dd8b6fb92b60c1f379a77818340c7c7d5b74b3a38c5f840ced46fe345cac223736cd741ef8238c1eb60321afa2dc622b410ca3e163db764913f444a5267cada59760163c743
P248
Q22011092-E150CF91-AB8E-4765-AC12-0D95BFB558D4Q24294688-4841BBB5-EE2C-44F3-8D1D-436675446CF4Q24300075-5A009DDE-0D46-4E28-AE24-F43C9879E9F9Q24319118-4C07F1BE-797C-4794-91A3-B7C70E336B54Q28508166-DDC14419-2178-46B8-8FC5-818948AF6241Q28508989-6C57E106-73E3-4B3A-B9A5-FD33E89557ABQ28512068-57005D9D-BB88-40C2-806B-0D94E62738A0Q30656298-56640F3B-A3CC-4B68-AE2F-F8A2E846DC7EQ33264425-C8CB7961-A9D0-420D-8F42-977440EC8A7CQ33279373-1EE84679-43F0-497F-B7CD-C7E1862ECC19Q33651766-16D0898B-B5DB-4DF4-8E2D-82E2A6E64A9DQ33826100-BC9DCE7C-E2FC-432F-9C0D-B95DAB4029E5Q33863846-E86A161A-2E8A-423F-A03E-626C4A290F82Q33894681-E6B3D939-7FDA-4B8E-896F-F90FBF0B6A07Q34066168-78A8D8EA-D652-4D1C-A7BB-EED9D3C024CFQ34207404-6C82E3ED-5A48-4C79-AD2C-F143E77FE501Q34263609-B80027D4-3265-4954-9419-C59936EAD263Q34298023-D6EE2B1B-23A9-4913-8E92-FED55E17548BQ34515641-CD4CF233-C31C-449C-A9FE-8444B60CBC9AQ34761284-3BD4D849-96D8-4EB8-92A5-2DC2AECD949AQ34793213-4B097AE9-C7D1-4B0E-9F67-A9ED659E5370Q34793288-E1609A69-589E-4921-A83D-7B4F5A181530Q34958968-05CA482C-2801-4685-9836-2A139D43C087Q35157505-7F6C50D2-1E9D-4A50-80FA-4EA55FF7463DQ35449040-0EF83C42-A1DF-4934-A016-660F242C0837Q35556621-3492A5C6-5911-4F39-A76F-54F62083F0FFQ35843389-CF182D78-48DD-4511-ACD0-5C7E989A3FF7Q36012956-FC41E1AD-9509-4F98-B208-640A4E64242BQ36139893-B3C4ABA4-7DC8-4651-815F-918AC0F5406AQ36293675-7932C5DC-DBD5-4E12-9654-D22E775D17C4Q36554853-E9652CB6-7998-466B-8508-82C7819CEC96Q37004486-A25A91D7-4991-4735-A844-12D260F1D1A9Q37039715-ECB8F1C5-6663-476F-864F-B5DD96BD6430Q37113015-E9464B6A-92A5-4706-8E5A-3A6ECAF2B3EAQ37964383-B78FA874-F248-4AA3-9057-558953D80575Q38234563-0BD98863-BC92-4A89-9AD2-740F72AF93C9Q39004902-2FE73844-5671-4FCB-9ECA-5B48EDBCF405Q39107690-5F3AB4B3-9E88-4DCA-829E-4F10F6FF9FF9Q39630331-BD708BFF-76CC-4C26-A2FD-F7C5A374D1E6Q40183981-A4B5E4E6-36D0-4061-AF15-81A175201515
P2860
Functional defects of a muscle-specific calpain, p94, caused by mutations associated with limb-girdle muscular dystrophy type 2A
description
1998 nî lūn-bûn
@nan
1998 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Functional defects of a muscle ...... dle muscular dystrophy type 2A
@ast
Functional defects of a muscle ...... dle muscular dystrophy type 2A
@en
Functional defects of a muscle ...... dle muscular dystrophy type 2A
@en-gb
Functional defects of a muscle ...... dle muscular dystrophy type 2A
@nl
type
label
Functional defects of a muscle ...... dle muscular dystrophy type 2A
@ast
Functional defects of a muscle ...... dle muscular dystrophy type 2A
@en
Functional defects of a muscle ...... dle muscular dystrophy type 2A
@en-gb
Functional defects of a muscle ...... dle muscular dystrophy type 2A
@nl
prefLabel
Functional defects of a muscle ...... dle muscular dystrophy type 2A
@ast
Functional defects of a muscle ...... dle muscular dystrophy type 2A
@en
Functional defects of a muscle ...... dle muscular dystrophy type 2A
@en-gb
Functional defects of a muscle ...... dle muscular dystrophy type 2A
@nl
P2093
P2860
P921
P356
P1476
Functional defects of a muscle ...... dle muscular dystrophy type 2A
@en
P2093
P2860
P304
17073-17078
P356
10.1074/JBC.273.27.17073
P407
P577
1998-07-01T00:00:00Z