Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads
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Transcription enhancer factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase gene, HSD3B1The molecular biology, biochemistry, and physiology of human steroidogenesis and its disordersAndrogen biosynthesis in castration-resistant prostate cancerAP-2 gamma and the homeodomain protein distal-less 3 are required for placental-specific expression of the murine 3 beta-hydroxysteroid dehydrogenase VI gene, Hsd3b6Adrenal androgen production in catarrhine primates and the evolution of adrenarchecDNA cloning and physical mapping of porcine 3 beta-hydroxysteroid dehydrogenase/Delta 5-Delta 4 isomerase.Proximal GATA-binding sites are essential for human HSD3B1 gene transcription in the placenta.The functions of key residues in the inhibitor, substrate and cofactor sites of human 3beta-hydroxysteroid dehydrogenase type 1 are validated by mutagenesis.Evidence that androgens are the primary steroids produced by Xenopus laevis ovaries and may signal through the classical androgen receptor to promote oocyte maturation.Identification of key amino acids responsible for the substantially higher affinities of human type 1 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD1) for substrates, coenzymes, and inhibitors relative to human 3beta-HSD2.A new insight into the molecular basis of 3beta-hydroxysteroid dehydrogenase deficiency.Selective inhibition of human 3β-hydroxysteroid dehydrogenase type 1 as a potential treatment for breast cancer.Cortisol stimulates secretion of dehydroepiandrosterone in human adrenocortical cells through inhibition of 3betaHSD2.Structure/function relationships responsible for coenzyme specificity and the isomerase activity of human type 1 3 beta-hydroxysteroid dehydrogenase/isomerase.Rational proteomics V: structure-based mutagenesis has revealed key residues responsible for substrate recognition and catalysis by the dehydrogenase and isomerase activities in human 3beta-hydroxysteroid dehydrogenase/isomerase type 1Differential regulation of human 3β-hydroxysteroid dehydrogenase type 2 for steroid hormone biosynthesis by starvation and cyclic AMP stimulation: studies in the human adrenal NCI-H295R cell model.Determining structure and function of steroid dehydrogenase enzymes by sequence analysis, homology modeling, and rational mutational analysis.Synthetic neurosteroids on brain protectionPolymorphisms in steroidogenesis genes, sex steroid levels, and high myopia in the Taiwanese populationSteroidogenic enzyme histochemistry in the testis of Sprague Dawley rats following the administration the water extracts from Carica papaya seed.Adrenal androgens and androgen precursors-definition, synthesis, regulation and physiologic actions.Mitochondrial 3β-hydroxysteroid dehydrogenase enzyme activity requires reversible pH-dependent conformational change at the intermembrane space.The next 150 years of congenital adrenal hyperplasia.Age and skin site related differences in steroid metabolism in male skin point to a key role of sebocytes in cutaneous hormone metabolismOvarian 3 beta-hydroxysteroid dehydrogenase/delta 5-4-isomerase of rainbow trout: its cDNA cloning and properties of the enzyme expressed in a mammalian cell.The Metabolism, Analysis, and Targeting of Steroid Hormones in Breast and Prostate Cancer.Effect of ovarian aging on androgen biosynthesis in a cynomolgus macaque modelHuman 3β-hydroxysteroid dehydrogenase type 1 in human breast cancer: clinical significance and prognostic associations.Variant allele of HSD3B1 increases progression to castration-resistant prostate cancerThe farnesoid X receptor regulates transcription of 3beta-hydroxysteroid dehydrogenase type 2 in human adrenal cells.Genetic associations with hypertension: meta-analyses of six candidate genetic variants.The higher affinity of human type 1 3beta-hydroxysteroid dehydrogenase (3beta-HSD1) for substrate and inhibitor steroids relative to human 3beta-HSD2 is validated in MCF-7 tumor cells and related to subunit interactions.Codon 367 polymorphism of the human type I 3 beta-hydroxysteroid dehydrogenase/isomerase gene (HS5DB3).Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action.Differences in substrate and inhibitor kinetics of human type 1 and type 2 3beta-hydroxysteroid dehydrogenase are explained by the type 1 mutant, H156Y.Characterization of a newly established cell line derived from human adrenocortical carcinoma.Target deletion of the bifunctional type 12 17β-hydroxysteroid dehydrogenase in mice results in reduction of androgen and estrogen levels in heterozygotes and embryonic lethality in homozygotes.Dihydrotestosterone synthesis pathways from inactive androgen 5α-androstane-3β,17β-diol in prostate cancer cells: Inhibition of intratumoural 3β-hydroxysteroid dehydrogenase activities by abiraterone.Light and electron microscopic immunohistochemistry of the localization of adrenal steroidogenic enzymes.Structure/function of the inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 and type 2 by trilostane.
P2860
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P2860
Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads
description
1991 nî lūn-bûn
@nan
1991 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1991年の論文
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1991年論文
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1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
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1991年論文
@zh-tw
1991年论文
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name
Structure and expression of a ...... e in human adrenals and gonads
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Structure and expression of a ...... e in human adrenals and gonads
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Structure and expression of a ...... e in human adrenals and gonads
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Structure and expression of a ...... e in human adrenals and gonads
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Structure and expression of a ...... e in human adrenals and gonads
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Structure and expression of a ...... e in human adrenals and gonads
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Structure and expression of a ...... e in human adrenals and gonads
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Structure and expression of a ...... e in human adrenals and gonads
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Structure and expression of a ...... e in human adrenals and gonads
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Structure and expression of a ...... e in human adrenals and gonads
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Structure and expression of a ...... e in human adrenals and gonads
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Structure and expression of a ...... e in human adrenals and gonads
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P2093
P3181
P356
P1476
Structure and expression of a ...... e in human adrenals and gonads
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P2093
Y Lachance
Y de Launoit
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P356
10.1210/MEND-5-8-1147
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P577
1991-08-01T00:00:00Z