Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
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Evidence of reduced oral bioavailability of paracetamol in rats following multiple ingestion of grapefruit juiceA cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophenXenobiotic Metabolism and Gut MicrobiomesPROXIMAL: a method for Prediction of Xenobiotic MetabolismData Mining FAERS to Analyze Molecular Targets of Drugs Highly Associated with Stevens-Johnson SyndromeAcetaminophen reactive intermediates target hepatic thioredoxin reductaseHigh-throughput and combinatorial gene expression on a chip for metabolism-induced toxicology screening.Influence of small doses of various drug vehicles on acetaminophen-induced liver injury.Histopathology and biochemistry analysis of the interaction between sunitinib and paracetamol in mice.Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics.Zebrafish as model organisms for studying drug-induced liver injuryNew insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme.Dietary saturated and monounsaturated fats protect against acute acetaminophen hepatotoxicity by altering fatty acid composition of liver microsomal membrane in ratsGene expression in rat hearts following oral administration of a single hepatotoxic dose of acetaminophen.Exacerbation of acetaminophen hepatotoxicity by the anthelmentic drug fenbendazolePharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses.Chlorogenic acid prevents acetaminophen-induced liver injury: the involvement of CYP450 metabolic enzymes and some antioxidant signalsProtective effects of 5-methoxypsoralen against acetaminophen-induced hepatotoxicity in mice.Target biomarker profile for the clinical management of paracetamol overdose.The effect of acetaminophen on ubiquitin homeostasis in Saccharomyces cerevisiaeAcetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity.Acetaminophen cytotoxicity is ameliorated in a human liver organotypic co-culture modelSummary of the National Institute of Child Health and Human Development-best pharmaceuticals for Children Act Pediatric Formulation Initiatives Workshop-Pediatric Biopharmaceutics Classification System Working Group.Does cytochrome P450 liver isoenzyme induction increase the risk of liver toxicity after paracetamol overdose?Loss of 5-lipoxygenase activity protects mice against paracetamol-induced liver toxicityRecent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Profiling the impact of medium formulation on morphology and functionality of primary hepatocytes in vitro.Application of physiologically based pharmacokinetic modeling to predict acetaminophen metabolism and pharmacokinetics in childrenCandidate gene polymorphisms in patients with acetaminophen-induced acute liver failure.Immature mice are more susceptible than adult mice to acetaminophen-induced acute liver injuryParacetamol metabolism and related genetic differences.Central role of mitochondria in drug-induced liver injury.Hepatotoxicity of tyrosine kinase inhibitors: clinical and regulatory perspectives.Pharmacokinetic drug interactions involving Ginkgo biloba.Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease.Acetaminophen/paracetamol: A history of errors, failures and false decisions.Choosing the safest acute therapy during chronic migraine prophylactic treatment: pharmacokinetic and pharmacodynamic considerations.Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver.p53- and Caspase-3-Independent Mechanism of Acetaminophen Effect on Human Neural Cells.Cooperativity in CYP2E1 metabolism of acetaminophen and styrene mixtures.
P2860
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P2860
Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
@ast
Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
@en
Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
@en-gb
Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
@nl
type
label
Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
@ast
Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
@en
Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
@en-gb
Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
@nl
prefLabel
Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
@ast
Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
@en
Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
@en-gb
Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
@nl
P2093
P2860
P921
P1433
P1476
Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
@en
P2093
P2860
P356
10.1080/00498250802512830
P407
P577
2009-01-01T00:00:00Z