Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
about
A fluorescence-based thermal shift assay identifies inhibitors of mitogen activated protein kinase kinase 4JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extensionNSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathwayJSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathwayHuman JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factorA phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cellsThe evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell deathMRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrestScaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathwayMirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alphaA human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathwaysDirect activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivativeSelective interaction of JNK protein kinase isoforms with transcription factorsIsolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets familyA novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuliMNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substratesMolecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brainDifferential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphataseActivation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinaseCharacterization of the structure and function of a novel MAP kinase kinase (MKK6)Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinaseInteraction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase.Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascadesConvergence of MAP kinase pathways on the ternary complex factor Sap-1a.Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinasep38 and extracellular signal-regulated kinases regulate the myogenic program at multiple stepsMixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complexSynergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activationInteraction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3The net repressor is regulated by nuclear export in response to anisomycin, UV, and heat shockTANK potentiates tumor necrosis factor receptor-associated factor-mediated c-Jun N-terminal kinase/stress-activated protein kinase activation through the germinal center kinase pathwayThe tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatasePurification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cellsActivation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinaseThe p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factorMKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokinesSignaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain
P2860
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P2860
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
description
1995 nî lūn-bûn
@nan
1995 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
@ast
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
@en
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
@en-gb
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
@nl
type
label
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
@ast
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
@en
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
@en-gb
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
@nl
prefLabel
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
@ast
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
@en
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
@en-gb
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
@nl
P2093
P3181
P356
P1433
P1476
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
@en
P2093
C Lange-Carter
F Mercurio
F X Claret
G L Johnson
H Martinetto
P304
P3181
P356
10.1126/SCIENCE.7716521
P407
P577
1995-04-14T00:00:00Z