The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling
about
The polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center polarizationRemote control of therapeutic T cells through a small molecule-gated chimeric receptor.The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosisT cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatasesSHP-1 and SHP-2 in T cells: two phosphatases functioning at many levelsMatched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human natural killer cells.T cell signal regulation by the actin cytoskeleton.Expression and function of the protein tyrosine phosphatase receptor J (PTPRJ) in normal mammary epithelial cells and breast tumors.Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production.CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cellsRegulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148.Inhibition of T-cell activation by syndecan-4 is mediated by CD148 through protein tyrosine phosphatase activity.Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding.Membrane domains in lymphocytes - from lipid rafts to protein scaffolds.Stochasticity and spatial heterogeneity in T-cell activation.The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor.Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane.Insights into the initiation of TCR signaling.Differential expression of CD148 on leukocyte subsets in inflammatory arthritis.Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity.Non-catalytic tyrosine-phosphorylated receptors.Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells.Ligand detection and discrimination by spatial relocalization: A kinase-phosphatase segregation model of TCR activation.Gene Expression Profiles of Human Phosphotyrosine Phosphatases Consequent to Th1 Polarisation and Effector Function.Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'.Modulation of T-cell receptor functional sensitivity via the opposing actions of protein tyrosine kinases and phosphatases: a mathematical model.Maintenance of murine platelet homeostasis by the kinase Csk and the phosphatase CD148.High-Affinity Ligands Can Trigger T Cell Receptor Signaling Without CD45 Segregation.
P2860
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P2860
The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The tyrosine phosphatase CD148 ...... tes prolonged T cell signaling
@ast
The tyrosine phosphatase CD148 ...... tes prolonged T cell signaling
@en
The tyrosine phosphatase CD148 ...... tes prolonged T cell signaling
@en-gb
The tyrosine phosphatase CD148 ...... tes prolonged T cell signaling
@nl
type
label
The tyrosine phosphatase CD148 ...... tes prolonged T cell signaling
@ast
The tyrosine phosphatase CD148 ...... tes prolonged T cell signaling
@en
The tyrosine phosphatase CD148 ...... tes prolonged T cell signaling
@en-gb
The tyrosine phosphatase CD148 ...... tes prolonged T cell signaling
@nl
prefLabel
The tyrosine phosphatase CD148 ...... tes prolonged T cell signaling
@ast
The tyrosine phosphatase CD148 ...... tes prolonged T cell signaling
@en
The tyrosine phosphatase CD148 ...... tes prolonged T cell signaling
@en-gb
The tyrosine phosphatase CD148 ...... tes prolonged T cell signaling
@nl
P2860
P921
P356
P1476
The tyrosine phosphatase CD148 ...... tes prolonged T cell signaling
@en
P2093
Joseph Lin
P2860
P304
P356
10.1083/JCB.200303040
P407
P50
P577
2003-08-18T00:00:00Z