Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases
about
A zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for endothelin-1 expressionThe kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation siteThe kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinaseMirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alphaDirect association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactionsPhosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinasesDYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functionsProtein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligasedDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in DrosophilaMirk/Dyrk1B mediates survival during the differentiation of C2C12 myoblastsOverexpression of the human MNB/DYRK1A gene induces formation of multinucleate cells through overduplication of the centrosomeDYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down SyndromeMouse models of Down syndrome as a tool to unravel the causes of mental disabilitiesGenome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartmentStructures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate RecognitionThe structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteineEngagement of DYRK2 in proper control for cell divisionCharacterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factorsCloning of human PRP4 reveals interaction with Clk1Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrateBikunin target genes in ovarian cancer cells identified by microarray analysisPhosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alphaIdentification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1ADyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitorsSelectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase InhibitorsDYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1.Novel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9DYRK3 activation, engagement of protein kinase A/cAMP response element-binding protein, and modulation of progenitor cell survivalMolecular targets for tumour progression in gastrointestinal stromal tumours.Interaction of the E1A oncoprotein with Yak1p, a novel regulator of yeast pseudohyphal differentiation, and related mammalian kinases.Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome.Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in micePhosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis.Tumor suppressor DYRK1A effects on proliferation and chemoresistance of AML cells by downregulating c-Myc.PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesisThe protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation sitedDYRK2 and Minibrain interact with the chromatin remodelling factors SNR1 and TRX.ChIP Display: novel method for identification of genomic targets of transcription factors.
P2860
1794a684e7ee3102b39c8ee2f680d8838ae8d42f46adb8dfda4b99d2eec861fc1ab6f14c7a0c66ef62122ce42dbd90fb0f65a1e2c4f5c9dd164fbc3676958bede3b208580851942d7a2f3461aab770b9841865b02892769a43722a06e75e04e20cfea794b315ec43565b3cc43ceb278bcaf782d2b5a46dbfc4be7e4dd2ce07e82eeebed4e3b0a3b6ee34f56fd378141e033a6a2ba4fe7247b7713bbcf6e31d38
P248
Q21284144-BAF3574C-C189-49CC-95E6-672FC34936A7Q24291137-52FD9DF7-F6FA-41F7-A8B3-AEDF46A7281FQ24291138-CC4096B0-2688-414A-9EF0-614508DB3322Q24295673-B3214C6A-D2C9-46F3-AC5A-CEB9C31FB767Q24297221-1E21D2F1-CAD1-4DB9-975D-58E6A759AD0CQ24298852-5A2289A5-6C21-46DB-A49C-C92AC0DD6CB4Q24300074-1F30C541-7844-4A50-AB7F-11A2B019F8F9Q24302518-0B9CFC6B-BB1F-4CE8-A41D-91547E92C43CQ24321736-E1AC3FF6-2CDF-4D5E-BA41-84E6B5F8BFBBQ24530188-925BAE2B-7058-4957-8C7B-51983435E59FQ24532054-119D3489-DF59-4FBF-BBFC-BA0301D3E0DBQ24803124-000E04E1-134D-47B8-BBC6-E76881E2633BQ26745413-4B278271-1492-43D0-9C5E-4680050735BCQ26863005-13BAE730-0B5A-43F2-9B09-1C76F69CDD65Q27312679-0947231F-46DE-47DC-847E-2024A17C17C2Q27678087-575BB279-C582-4C1A-A6A6-9799932B6C94Q27700733-AB1FB710-4D0B-4703-91D7-1117D346F96DQ28081810-7FBB3FCB-96E3-4D5C-9A8A-50B90C92A805Q28185216-38EF622B-C2A5-49A2-86AA-04CF56757BCDQ28202917-A5FF6BFC-44AC-4BBC-B4C3-5079AB829E17Q28205049-FA4FD6A5-60AF-4B00-910E-78F9AC1DBD07Q28207799-D69A1659-5BC1-4DF1-8EA6-F398A399B938Q28305184-58AAA767-FB7B-4142-8446-4CA08BF1FB81Q28362375-AF618FA3-E3DB-41A5-B86C-D093BB8D94B6Q28510482-5B367755-24A6-41E3-95FD-07E84729E137Q28541616-804B5898-4E90-4AC1-B03F-BFFA962DE48FQ28546672-D783EF13-6A45-449C-91CA-D1DA03DFCE06Q28574593-DEBEC089-CB45-42C3-93FB-1A74C9F0E8C4Q28591067-64B587F1-521F-40D2-85E4-C719D43177C4Q28592229-FC5732E2-1913-4C31-9312-2D010176A342Q30312213-B71C4B69-8373-40C8-BD89-CBB8E4A8C6C0Q30454229-F8A99182-C42E-4689-BD88-1C3A3B270093Q30490193-8FB2E788-8AFE-4E41-99BC-41FD5829EDE0Q30531707-3B27C0D5-7B1D-462F-9279-BCEC59D62D60Q30754477-E829EF54-9AA8-4D3F-B617-A34470800EB6Q31164546-2605A495-7008-4BAD-8836-AA7337098E0CQ32884406-5A3CEE33-BA6E-4DE7-9EA4-C04F48F525AFQ33235281-B94742B9-F12F-41E6-B613-3D152B26123EQ33242077-19752BE3-628D-44D4-8E30-B968C6324E44Q33340217-85811FCD-EFDD-4ED9-9218-EA860BA2BA0A
P2860
Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases
description
1998 nî lūn-bûn
@nan
1998 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Sequence characteristics, subc ...... al specificity protein kinases
@ast
Sequence characteristics, subc ...... al specificity protein kinases
@en
Sequence characteristics, subc ...... al specificity protein kinases
@en-gb
Sequence characteristics, subc ...... al specificity protein kinases
@nl
type
label
Sequence characteristics, subc ...... al specificity protein kinases
@ast
Sequence characteristics, subc ...... al specificity protein kinases
@en
Sequence characteristics, subc ...... al specificity protein kinases
@en-gb
Sequence characteristics, subc ...... al specificity protein kinases
@nl
prefLabel
Sequence characteristics, subc ...... al specificity protein kinases
@ast
Sequence characteristics, subc ...... al specificity protein kinases
@en
Sequence characteristics, subc ...... al specificity protein kinases
@en-gb
Sequence characteristics, subc ...... al specificity protein kinases
@nl
P2093
P921
P3181
P356
P1476
Sequence characteristics, subc ...... al specificity protein kinases
@en
P2093
P304
P3181
P356
10.1074/JBC.273.40.25893
P407
P577
1998-10-02T00:00:00Z