LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
about
NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemiaLSD1/CoREST is an allosteric nanoscale clamp regulated by H3-histone-tail molecular recognition.Histone demethylase LSD1 controls the phenotypic plasticity of cancer cellsEpigenomics of leukemia: from mechanisms to therapeutic applicationsKDM1 class flavin-dependent protein lysine demethylasesSetd1a and NURF mediate chromatin dynamics and gene regulation during erythroid lineage commitment and differentiationLSD1 inhibition: a therapeutic strategy in cancer?Histone lysine-specific demethylase 1 (LSD1) protein is involved in Sal-like protein 4 (SALL4)-mediated transcriptional repression in hematopoietic stem cellsCatalytic mechanism investigation of lysine-specific demethylase 1 (LSD1): a computational studyCorepressor Rcor1 is essential for murine erythropoiesisAntagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiationAnalysis of microRNA transcriptome by deep sequencing of small RNA libraries of peripheral bloodH4R3 methylation facilitates beta-globin transcription by regulating histone acetyltransferase binding and H3 acetylationEstrogen-mediated epigenetic repression of large chromosomal regions through DNA loopingLysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin inductionSpecific nuclear localizing sequence directs two myosin isoforms to the cell nucleus in calmodulin-sensitive manner.Regulation of mouse steroidogenesis by WHISTLE and JMJD1C through histone methylation balanceLSD1: biologic roles and therapeutic targeting.A hypomorphic lsd1 allele results in heart development defects in miceLoss of lysine-specific demethylase 1 nonautonomously causes stem cell tumors in the Drosophila ovaryRole of helix-loop-helix proteins during differentiation of erythroid cells.Transcription factor networks in erythroid cell and megakaryocyte developmentChromatin boundaries require functional collaboration between the hSET1 and NURF complexes.Histone demethylase LSD1-mediated repression of GATA-2 is critical for erythroid differentiationKDM3B is the H3K9 demethylase involved in transcriptional activation of lmo2 in leukemiaGATA-binding protein 4 (GATA-4) and T-cell acute leukemia 1 (TAL1) regulate myogenic differentiation and erythropoietin response via cross-talk with Sirtuin1 (Sirt1)LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2.T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis.Control of developmentally primed erythroid genes by combinatorial co-repressor actionsAcetylation of histone deacetylase 1 regulates NuRD corepressor complex activityDynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis.Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells.Epigenetic regulation of LSD1 during mammary carcinogenesis.The malignant brain tumor (MBT) domain protein SFMBT1 is an integral histone reader subunit of the LSD1 demethylase complex for chromatin association and epithelial-to-mesenchymal transition.Key roles of histone methyltransferase and demethylase in leukemogenesis.Histone methylation in myelodysplastic syndromes.Concise review: Blood relatives: formation and regulation of hematopoietic stem cells by the basic helix-loop-helix transcription factors stem cell leukemia and lymphoblastic leukemia-derived sequence 1.The role of chromatin modifiers in normal and malignant hematopoiesisThe DNA binding factor Hmg20b is a repressor of erythroid differentiation.A novel complex, RUNX1-MYEF2, represses hematopoietic genes in erythroid cells
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P2860
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
@ast
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
@en
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
@en-gb
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
@nl
type
label
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
@ast
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
@en
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
@en-gb
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
@nl
prefLabel
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
@ast
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
@en
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
@en-gb
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
@nl
P2093
P2860
P921
P3181
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P1476
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
@en
P2093
Constance Noguchi
Kristell Valverde
Suming Huang
Xingguo Li
P2860
P304
P3181
P356
10.1073/PNAS.0900437106
P407
P577
2009-06-23T00:00:00Z