Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment
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Choline Metabolism Alteration: A Focus on Ovarian CancerSurfactant phospholipid metabolismCholine metabolism-based molecular diagnosis of cancer: an updateHuman Choline Kinase-α Promotes Hepatitis C Virus RNA Replication through Modulation of Membranous Viral Replication Complex FormationCrystal Structures of Human Choline Kinase Isoforms in Complex with Hemicholinium-3: SINGLE AMINO ACID NEAR THE ACTIVE SITE INFLUENCES INHIBITOR SENSITIVITYThe mechanism of allosteric coupling in choline kinase α1 revealed by the action of a rationally designed inhibitorDetermination of potential scaffolds for human choline kinase α1 by chemical deconvolution studiesPharmacophore-Based Virtual Screening to Discover New Active Compounds for Human Choline Kinase α1Highly specific antibodies for co-detection of human choline kinase α1 and α2 isoformsPlasmodium falciparum Choline Kinase Inhibition Leads to a Major Decrease in Phosphatidylethanolamine Causing Parasite DeathSilencing of the glycerophosphocholine phosphodiesterase GDPD5 alters the phospholipid metabolite profile in a breast cancer model in vivo as monitored by (31) P MRS.A new family of choline kinase inhibitors with antiproliferative and antitumor activity derived from natural products.Phospholipase D1 and choline kinase-α are interactive targets in breast cancer.1H/31P polarization transfer at 9.4 Tesla for improved specificity of detecting phosphomonoesters and phosphodiesters in breast tumor models.A critical role for choline kinase-alpha in the aggressiveness of bladder carcinomasProtein and lipid MALDI profiles classify breast cancers according to the intrinsic subtype.Nanoplex delivery of siRNA and prodrug enzyme for multimodality image-guided molecular pathway targeted cancer therapyCholine kinase alpha and hexokinase-2 protein expression in hepatocellular carcinoma: association with survival.Identification of potential synthetic lethal genes to p53 using a computational biology approachAdmixture mapping and subsequent fine-mapping suggests a biologically relevant and novel association on chromosome 11 for type 2 diabetes in African Americans.Choline metabolism in malignant transformation.Choline kinase inhibition in rheumatoid arthritis.Clinical significance of serum lipids in idiopathic pulmonary alveolar proteinosis.Choline Ameliorates Deficits in Balance Caused by Acute Neonatal Ethanol Exposure.Conditional mutagenesis of a novel choline kinase demonstrates plasticity of phosphatidylcholine biogenesis and gene expression in Toxoplasma gondii.Choline kinase alpha-Putting the ChoK-hold on tumor metabolism.Phosphorylation of Human Choline Kinase Beta by Protein Kinase A: Its Impact on Activity and Inhibition.Genome-Wide Association Study for Muscle Fat Content and Abdominal Fat Traits in Common Carp (Cyprinus carpio).Evidence for bidirectional endocannabinoid transport across cell membranesras-Induced up-regulation of CTP:phosphocholine cytidylyltransferase α contributes to malignant transformation of intestinal epithelial cells.Serum metabolomic profiling facilitates the non-invasive identification of metabolic biomarkers associated with the onset and progression of non-small cell lung cancer.Characterization of choline kinase in human endothelial cells.Phospholipids of tumor extracellular vesicles stratify gefitinib-resistant nonsmall cell lung cancer cells from gefitinib-sensitive cellsLights and shadows of proteomic technologies for the study of protein species including isoforms, splicing variants and protein post-translational modifications.The role of phosphatidylcholine and choline metabolites to cell proliferation and survival.The fat side of prostate cancer.Sphingolipid metabolism and its role in the skeletal tissues.New more polar symmetrical bipyridinic compounds: new strategy for the inhibition of choline kinase α1.Targeting Phospholipid Metabolism in Cancer.Human prostate cell lines from normal and tumourigenic epithelia differ in the pattern and control of choline lipid headgroups released into the medium on stimulation of protein kinase C.
P2860
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P2860
Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment
description
2009 nî lūn-bûn
@nan
2009 թուականին հրատարակուած գիտական յօդուած
@hyw
2009 թվականին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Differential role of human cho ...... in cancer onset and treatment
@ast
Differential role of human cho ...... in cancer onset and treatment
@en
Differential role of human cho ...... in cancer onset and treatment
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Differential role of human cho ...... in cancer onset and treatment
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type
label
Differential role of human cho ...... in cancer onset and treatment
@ast
Differential role of human cho ...... in cancer onset and treatment
@en
Differential role of human cho ...... in cancer onset and treatment
@en-gb
Differential role of human cho ...... in cancer onset and treatment
@nl
prefLabel
Differential role of human cho ...... in cancer onset and treatment
@ast
Differential role of human cho ...... in cancer onset and treatment
@en
Differential role of human cho ...... in cancer onset and treatment
@en-gb
Differential role of human cho ...... in cancer onset and treatment
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P2093
P2860
P50
P921
P3181
P1433
P1476
Differential role of human cho ...... in cancer onset and treatment
@en
P2093
David Gallego-Ortega
Fatima Valdes-Mora
Maria Angeles Ramos
P2860
P3181
P356
10.1371/JOURNAL.PONE.0007819
P407
P577
2009-11-12T00:00:00Z