Reciprocal regulation of neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo. Implications for human breast cancer
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Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.Molecular genetics of the caveolin gene family: implications for human cancers, diabetes, Alzheimer disease, and muscular dystrophy.Stromal cell expression of caveolin-1 predicts outcome in breast cancerExpression of caveolin-1 and -2 in differentiating PC12 cells and dorsal root ganglion neurons: caveolin-2 is up-regulated in response to cell injuryCaveolin-1, a stress-related oncotarget, in drug resistanceRegulation of G protein-coupled receptor kinases by caveolinGenes encoding human caveolin-1 and -2 are co-localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancersCaveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor geneModulation of myoblast fusion by caveolin-3 in dystrophic skeletal muscle cells: implications for Duchenne muscular dystrophy and limb-girdle muscular dystrophy-1CSpatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cellsThe Role of Caveolin 1 in HIV Infection and Pathogenesis.Caveolin-1 mutations in human breast cancer: functional association with estrogen receptor alpha-positive status.The tetraspan protein EMP2 regulates expression of caveolin-1.Caveolins, liquid-ordered domains, and signal transduction.Complexity of signal transduction mediated by ErbB2: clues to the potential of receptor-targeted cancer therapy.Protein-protein interaction reveals synergistic discrimination of cancer phenotypeTargeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade.Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts.Endothelial and smooth muscle cell ion channels in pulmonary vasoconstriction and vascular remodelingCaveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism.Caveolin-1: a tumor-promoting role in human cancer.Caveolin-1 is required for kinase suppressor of Ras 1 (KSR1)-mediated extracellular signal-regulated kinase 1/2 activation, H-RasV12-induced senescence, and transformationHIV infection upregulates caveolin 1 expression to restrict virus production.Knockdown of caveolin-1 by siRNA inhibits the transformation of mouse hepatoma H22 cells in vitro and in vivoRegulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol.Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic miceDynamics of plasma membrane microdomains and cross-talk to the insulin signalling cascade.Caveolin-1 deficiency (-/-) conveys premalignant alterations in mammary epithelia, with abnormal lumen formation, growth factor independence, and cell invasiveness.Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: Caveolin-1 antagonizes cyclin D1 function in mammary epithelial cells.Novel insights into the role of caveolin-2 in cell- and tissue-specific signaling and function.Caveolin-1/3 double-knockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype.Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasiaAbsence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation.Regulation of alveolar epithelial cell apoptosis and pulmonary fibrosis by coordinate expression of components of the fibrinolytic systemCaveolin-1 in oncogenic transformation, cancer, and metastasis.Caveolin-1 expression in benign and malignant lesions of the breast.Regulation of Cripto-1 signaling and biological activity by caveolin-1 in mammary epithelial cellsImpact of caveolin-1 expression on prognosis of pancreatic ductal adenocarcinoma.Clinical significance of Caveolin-1, Caveolin-2 and HER2/neu mRNA expression in human breast cancer.Lipid mediators in membrane rafts are important determinants of human health and disease.
P2860
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P2860
Reciprocal regulation of neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo. Implications for human breast cancer
description
1998 nî lūn-bûn
@nan
1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Reciprocal regulation of neu t ...... ations for human breast cancer
@ast
Reciprocal regulation of neu t ...... ations for human breast cancer
@en
Reciprocal regulation of neu t ...... ations for human breast cancer
@en-gb
Reciprocal regulation of neu t ...... ations for human breast cancer
@nl
type
label
Reciprocal regulation of neu t ...... ations for human breast cancer
@ast
Reciprocal regulation of neu t ...... ations for human breast cancer
@en
Reciprocal regulation of neu t ...... ations for human breast cancer
@en-gb
Reciprocal regulation of neu t ...... ations for human breast cancer
@nl
prefLabel
Reciprocal regulation of neu t ...... ations for human breast cancer
@ast
Reciprocal regulation of neu t ...... ations for human breast cancer
@en
Reciprocal regulation of neu t ...... ations for human breast cancer
@en-gb
Reciprocal regulation of neu t ...... ations for human breast cancer
@nl
P2093
P2860
P921
P356
P1476
Reciprocal regulation of neu t ...... ations for human breast cancer
@en
P2093
A Karnezis
J A Engelman
M P Lisanti
R G Pestell
W J Muller
P2860
P304
20448-20455
P356
10.1074/JBC.273.32.20448
P407
P577
1998-08-01T00:00:00Z