A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity
about
A Novel SHOC2 Variant in RasopathyDistinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signallingRaf family kinases: old dogs have learned new tricksPhosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking proteinMutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hairChanges in prostate gene expression in men undergoing an intensive nutrition and lifestyle interventionThe RASopathiesShoc2 is targeted to late endosomes and required for Erk1/2 activation in EGF-stimulated cellsFunctional Integration of the Conserved Domains of Shoc2 ScaffoldRaf-interactome in tuning the complexity and diversity of Raf function.The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans.Signalling scaffolds and local organization of cellular behaviourA functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in DrosophilaGenetic analysis of Ras signalling pathways in cell proliferation, migration and survival.A feature selection approach for identification of signature genes from SAGE data.How Genetics Has Helped Piece Together the MAPK Signaling Pathway.Learning transcriptional regulatory networks from high throughput gene expression data using continuous three-way mutual information.Ras and calcium signaling pathways converge at Raf1 via the Shoc2 scaffold proteinNoonan syndrome: clinical aspects and molecular pathogenesis.HUWE1 is a molecular link controlling RAF-1 activity supported by the Shoc2 scaffold.Disorders of dysregulated signal traffic through the RAS-MAPK pathway: phenotypic spectrum and molecular mechanismsKidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation.Noonan syndrome and clinically related disorders.Shoc2/Sur8 protein regulates neurite outgrowthCombined anticancer effects of sphingosine kinase inhibitors and sorafenib.M-Ras induces Ral and JNK activation to regulate MEK/ERK-independent gene expression in MCF-7 breast cancer cells.Transcriptional hallmarks of Noonan syndrome and Noonan-like syndrome with loose anagen hair.The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding RegionsCandidate genes contributing to the aggressive phenotype of mantle cell lymphoma.Combined Pan-RAF and MEK Inhibition Overcomes Multiple Resistance Mechanisms to Selective RAF Inhibitors.SHOC2 and CRAF mediate ERK1/2 reactivation in mutant NRAS-mediated resistance to RAF inhibitor.Spatial control of Shoc2-scaffold-mediated ERK1/2 signaling requires remodeling activity of the ATPase PSMC5.Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling.Raf kinases: oncogenesis and drug discovery.Shoc2-tranduced ERK1/2 motility signals--Novel insights from functional genomics.Desmoglein-1/Erbin interaction suppresses ERK activation to support epidermal differentiation.Targeting the PI3K and MAPK pathways to treat Kaposi's-sarcoma-associated herpes virus infection and pathogenesis.AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion.Recurrent inactivating RASA2 mutations in melanoma.Sur8 mediates tumorigenesis and metastasis in colorectal cancer.
P2860
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P2860
A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity
description
2006 nî lūn-bûn
@nan
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
A phosphatase holoenzyme compr ...... ector to modulate Raf activity
@ast
A phosphatase holoenzyme compr ...... ector to modulate Raf activity
@en
A phosphatase holoenzyme compr ...... ector to modulate Raf activity
@en-gb
A phosphatase holoenzyme compr ...... ector to modulate Raf activity
@nl
type
label
A phosphatase holoenzyme compr ...... ector to modulate Raf activity
@ast
A phosphatase holoenzyme compr ...... ector to modulate Raf activity
@en
A phosphatase holoenzyme compr ...... ector to modulate Raf activity
@en-gb
A phosphatase holoenzyme compr ...... ector to modulate Raf activity
@nl
prefLabel
A phosphatase holoenzyme compr ...... ector to modulate Raf activity
@ast
A phosphatase holoenzyme compr ...... ector to modulate Raf activity
@en
A phosphatase holoenzyme compr ...... ector to modulate Raf activity
@en-gb
A phosphatase holoenzyme compr ...... ector to modulate Raf activity
@nl
P2093
P3181
P1433
P1476
A phosphatase holoenzyme compr ...... ector to modulate Raf activity
@en
P2093
Frank McCormick
Juan Oses-Prieto
Mike Fried
Pablo Rodriguez-Viciana
P304
P3181
P356
10.1016/J.MOLCEL.2006.03.027
P407
P577
2006-04-21T00:00:00Z