HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing - sprookjes - yvandenbroek - TriplyDB

HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing

HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing

http://www.wikidata.org/entity/Q24319786

about

Oncogenic function of DACT1 in colon cancer through the regulation of β-catenin Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus Protein kinase A-mediated 14-3-3 association impedes human Dapper1 to promote dishevelled degradation Aberrant regulation of Wnt signaling in hepatocellular carcinoma Dickkopfs and Wnt/β-catenin signalling in liver cancer Disruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/β-catenin signaling Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling network Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in mice All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases Prognostic significance of the methylation of Wnt pathway antagonists-CXXC4, DACT2, and the inhibitors of sonic hedgehog signaling-ZIC1, ZIC4, and HHIP in head and neck squamous cell carcinomas.Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer.Methylated CpG site count of dapper homolog 1 (DACT1) promoter prediction the poor survival of gastric cancer Correlation analysis of liver tumor-associated genes with liver regeneration Concurrent epigenetic silencing of wnt/β-catenin pathway inhibitor genes in B cell chronic lymphocytic leukaemia.Retinoic acid negatively regulates dact3b expression in the hindbrain of zebrafish embryos.DACT2 is frequently methylated in human gastric cancer and methylation of DACT2 activated Wnt signaling.Upregulated MiR-1269 in hepatocellular carcinoma and its clinical significance DNA methylation, microRNAs, and their crosstalk as potential biomarkers in hepatocellular carcinoma.Cytoplasmic HDPR1 is involved in regional lymph node metastasis and tumor development via beta-catenin accumulation in esophageal squamous cell carcinoma.Dapper homolog 1 is a novel tumor suppressor in gastric cancer through inhibiting the nuclear factor-κB signaling pathway.Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts Repair and regeneration: opportunities for carcinogenesis from tissue stem cells Reduced expression of DACT2 promotes hepatocellular carcinoma progression: involvement of methylation-mediated gene silencing DACT1, an antagonist to Wnt/β-catenin signaling, suppresses tumor cell growth and is frequently silenced in breast cancer.Epigenetic regulation of the Wnt signaling inhibitor DACT2 in human hepatocellular carcinoma.Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma Association analysis of DACT1 genetic variants and gastric cancer risk in a Chinese Han population: a case-control study.Characterization of hepatocellular carcinoma related genes and metabolites in human nonalcoholic fatty liver disease.DACT2 silencing by promoter CpG methylation disrupts its regulation of epithelial-to-mesenchymal transition and cytoskeleton reorganization in breast cancer cells.Dysregulated expression of dickkopfs for potential detection of hepatocellular carcinoma.Upregulation of DACT2 suppresses proliferation and enhances apoptosis of glioma cell via inactivation of YAP signaling pathway Myc-interacting zinc-finger protein 1 positively regulates Wnt signalling by protecting Dishevelled from Dapper1-mediated degradation.Dpr Acts as a molecular switch, inhibiting Wnt signaling when unphosphorylated, but promoting Wnt signaling when phosphorylated by casein kinase Idelta/epsilon.DACT1 Overexpression in type I ovarian cancer inhibits malignant expansion and cis-platinum resistance by modulating canonical Wnt signalling and autophagy.MiR-324-3p promotes tumor growth through targeting DACT1 and activation of Wnt/β-catenin pathway in hepatocellular carcinoma.Liver stem cells and molecular signaling pathways in hepatocellular carcinoma.DACT1 overexpression inhibits proliferation, enhances apoptosis, and increases daunorubicin chemosensitivity in KG-1α cells.Dact gene expression profiles suggest a role for this gene family in integrating Wnt and TGF-β signaling pathways during chicken limb development.

P2860

644a9e441a3d877ce9e36418923fdc4a05189ee3

P248

Q24311321-D8937A57-3E48-4F66-A73B-6B99FD7EFBE9 Q24320123-D8DAF347-13D7-4D92-BAAF-77A2411EB5F6 Q24329167-45361A01-E5FD-450A-B932-E596D4F11577 Q24338245-60A45300-F35A-4B3E-A1A7-4AA8EDE33443 Q28079789-E2ADCE78-3BE3-4FEA-BAF5-09C1379733E7 Q28391394-6B67D228-9F71-4826-B0F7-C3504B40A4B7 Q28508395-27E0AE4C-A6B9-4043-9240-27C0B42A312A Q28510784-37108A44-E740-4C52-BA6D-1E6BB349F3DB Q28587453-BBB24127-FCFB-42FE-8EA0-B226B6977BFF Q28594193-F169735E-5F42-4F25-8849-A564FA7A0633 Q33720509-1375432B-1AE8-4D07-8662-B5A0F95931C7 Q33771070-A99576CF-9285-41BE-85AB-CA6DF00FA9D8 Q34178502-96371898-367B-4DA1-B55B-D063963D12D6 Q34233029-7908E1B2-12C8-4CF0-828C-842B31D194F3 Q34294336-BA74CBE6-A402-414F-8E2A-969DE4E9BC84 Q34623895-7E23FC69-3F35-4934-A92F-276FD85F5029 Q34704853-D5ADE750-C257-4B4B-A618-B7C57EF420E7 Q35173587-912EE379-83D7-4937-96EE-E922BE64A7A4 Q35197356-5BAB96E5-C89E-4088-AE78-0A61489CAE19 Q35440976-C434F483-D33D-4921-8DC6-97C0A1E580EF Q36498313-519E78B6-651D-4CB5-9FCB-99C829B50FD3 Q36516108-5CCF6F54-B82F-4242-8262-045C4B2166CD Q36517050-65B24337-5BFE-45E2-9B0B-9A439464A800 Q36707939-14B8A2FE-A979-4868-A619-D5937E84EB4A Q36903109-28D3DD8F-EDF6-41B7-9222-2F833018DA28 Q36906155-E512E11D-5C1C-490E-82B6-5FB890059F7A Q37138658-332BB317-BB08-4E1F-9735-5AE63328B8C3 Q37305957-E03A8651-21BA-473A-A11B-8A69B1CFBEC0 Q37622144-6D7C72CC-ED0C-48B2-88A5-8F0F5E414F07 Q37684412-4AE4E242-3666-4A8C-9A65-BA9CC8D29D30 Q38210247-7CFED06B-86D2-4270-92FC-75DB18E84A95 Q38630701-634B2696-B48E-46DC-9716-3EFC25485DA9 Q38923265-0C01DC4C-83D8-4ED0-9A26-B318382B9465 Q39851874-122EAF4D-728C-446B-8BBE-79773D2D4D38 Q41516517-9C579895-7754-4E8B-84E1-6B292AAF8B65 Q42371572-F4AD9EAB-8DC7-48DA-9E5E-3FF1CB61C358 Q43148137-59C14E6F-F6DF-4597-B818-0AE6C188AFB5 Q47646224-0EF6EE04-560E-4750-A9F6-FA3713146165 Q50759129-CF5D25AF-A5F7-440C-AA99-3F0DB3743732

P2860

HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing

http://www.wikidata.org/entity/Q24319786

description

2005 nî lūn-bûn

@nan

2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

name

HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing

@ast

HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing

@en

HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing

@en-gb

HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing

@nl

type

label

HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing

@ast

HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing

@en

HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing

@en-gb

HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing

@nl

prefLabel

HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing

@ast

HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing

@en

HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing

@en-gb

HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing

@nl

P1433

Q24319786-0C6C7920-34C6-4447-9415-242871023514

P1476

Q24319786-1B114E51-3195-467A-90CD-3CDC5472A779

P2093

Q24319786-3849ED94-2E49-4E99-93F5-7138BE3B1BBB

Q24319786-7D770FA1-41D8-40D6-B5B6-4445716FDBB2

Q24319786-AEE8BA2A-7560-4941-8148-645E2C74677B

Q24319786-B409047E-42DC-4682-8EBE-D8D12B69FCF2

Q24319786-F62AB7A8-A303-4AC0-B70A-EF65143B61C4

Q24319786-F636880D-690D-4F5A-ADBF-39A5D714F85D

P2860

Q24319786-03A36BC7-A87A-4348-BCB9-4C3369BBC051

Q24319786-12F67E0B-4436-4F49-8FA0-85E902CD316D

Q24319786-1401960E-EB20-47D9-B6CC-48A086663DF2

Q24319786-14FB2DE6-61A3-4790-BD24-D3F0B49B43B0

Q24319786-3A96CB36-2C20-4F01-9F0C-7BF81AFFB612

Q24319786-3A9A1441-EFA0-4B91-86E9-EDE7B106029A

Q24319786-3D51191D-D579-44ED-9BF8-946319259B17

Q24319786-53120F1E-5AE0-4B0A-B1B9-368FB5CBFE63

Q24319786-55ADF3F3-DDB9-41EB-935F-348A6FB81ECF

Q24319786-67883911-97C0-4E0A-A402-702C2676A07B

P2888

Q24319786-1E2890CB-1D60-4556-9B20-563E0E94F8DB

P304

Q24319786-45591219-37A0-446D-AE0A-BFD0E2E4CAD5

P31

Q24319786-80505B15-CEEE-4346-B10E-55CB00C12ED7

P3181

Q24319786-88E6AEC2-581C-43F8-9AA5-D4A2CDDB3F03

P356

Q24319786-A764CB93-1DEA-4EE6-840C-08EB864D89D3

P407

Q24319786-CE7DDE26-0B58-41E5-8234-56FE52BF7CE7

P433

Q24319786-C6DE5C5D-46F7-4371-9E71-689AD1B8CFA6

P478

Q24319786-97923ED3-FE75-4554-92FA-58A9CFC36668

P50

Q24319786-A5C30F3F-E09E-48C4-BB63-6DB433BAEFA9

P577

Q24319786-9B7D895B-FDEF-4318-BA66-52FE4A846DD2

P5875

Q24319786-C298AA30-9C8F-4991-8FCB-571AF5E69C89

P6179

Q24319786-E791DE95-A777-4FAE-9A86-13EA121DEEEF

P698

Q24319786-10E5D84D-1E1B-4979-BD33-AAAEB891C2B7

P921

Q24319786-78E09517-160E-4EFC-B74E-594A0F91103A

Q24319786-A170D681-F8D7-4DEE-9E20-338B4B22636D

Q24319786-AF082FD6-B50A-4422-B9E6-90F8F1D30BB2

P3181

P356

P1433

P1476

HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing

@en

P2093

Chun-Ming Wong

http://www.w3.org/2001/XMLSchema#string

Chung-Yiu Chan

http://www.w3.org/2001/XMLSchema#string

Kok-Lung Chan

http://www.w3.org/2001/XMLSchema#string

Man-Fong Lee

http://www.w3.org/2001/XMLSchema#string

Sheung-Tat Fan

http://www.w3.org/2001/XMLSchema#string

Tai-On Yau

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of c-MYC as a target of the APC pathway

Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1.

High sensitivity mapping of methylated cytosines

Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation

Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53

Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

P2888

P304

1607-1614

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

3265043

http://www.w3.org/2001/XMLSchema#string

P356

10.1038/SJ.ONC.1208340

http://www.w3.org/2001/XMLSchema#string

P407

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

24

http://www.w3.org/2001/XMLSchema#string

P50

P577

2005-02-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

8148170

http://www.w3.org/2001/XMLSchema#string

P6179

1026897949

http://www.w3.org/2001/XMLSchema#string

P698

15580286

http://www.w3.org/2001/XMLSchema#string

P921

positive regulation of canonical Wnt signaling pathway

Dishevelled binding antagonist of beta catenin 1