HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing
about
Oncogenic function of DACT1 in colon cancer through the regulation of β-cateninFunctional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cellsDapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleusProtein kinase A-mediated 14-3-3 association impedes human Dapper1 to promote dishevelled degradationAberrant regulation of Wnt signaling in hepatocellular carcinomaDickkopfs and Wnt/β-catenin signalling in liver cancerDisruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/β-catenin signalingDact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling networkLoss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in miceAll Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinasesPrognostic significance of the methylation of Wnt pathway antagonists-CXXC4, DACT2, and the inhibitors of sonic hedgehog signaling-ZIC1, ZIC4, and HHIP in head and neck squamous cell carcinomas.Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer.Methylated CpG site count of dapper homolog 1 (DACT1) promoter prediction the poor survival of gastric cancerCorrelation analysis of liver tumor-associated genes with liver regenerationConcurrent epigenetic silencing of wnt/β-catenin pathway inhibitor genes in B cell chronic lymphocytic leukaemia.Retinoic acid negatively regulates dact3b expression in the hindbrain of zebrafish embryos.DACT2 is frequently methylated in human gastric cancer and methylation of DACT2 activated Wnt signaling.Upregulated MiR-1269 in hepatocellular carcinoma and its clinical significanceDNA methylation, microRNAs, and their crosstalk as potential biomarkers in hepatocellular carcinoma.Cytoplasmic HDPR1 is involved in regional lymph node metastasis and tumor development via beta-catenin accumulation in esophageal squamous cell carcinoma.Dapper homolog 1 is a novel tumor suppressor in gastric cancer through inhibiting the nuclear factor-κB signaling pathway.Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblastsRepair and regeneration: opportunities for carcinogenesis from tissue stem cellsReduced expression of DACT2 promotes hepatocellular carcinoma progression: involvement of methylation-mediated gene silencingDACT1, an antagonist to Wnt/β-catenin signaling, suppresses tumor cell growth and is frequently silenced in breast cancer.Epigenetic regulation of the Wnt signaling inhibitor DACT2 in human hepatocellular carcinoma.Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinomaAssociation analysis of DACT1 genetic variants and gastric cancer risk in a Chinese Han population: a case-control study.Characterization of hepatocellular carcinoma related genes and metabolites in human nonalcoholic fatty liver disease.DACT2 silencing by promoter CpG methylation disrupts its regulation of epithelial-to-mesenchymal transition and cytoskeleton reorganization in breast cancer cells.Dysregulated expression of dickkopfs for potential detection of hepatocellular carcinoma.Upregulation of DACT2 suppresses proliferation and enhances apoptosis of glioma cell via inactivation of YAP signaling pathwayMyc-interacting zinc-finger protein 1 positively regulates Wnt signalling by protecting Dishevelled from Dapper1-mediated degradation.Dpr Acts as a molecular switch, inhibiting Wnt signaling when unphosphorylated, but promoting Wnt signaling when phosphorylated by casein kinase Idelta/epsilon.DACT1 Overexpression in type I ovarian cancer inhibits malignant expansion and cis-platinum resistance by modulating canonical Wnt signalling and autophagy.MiR-324-3p promotes tumor growth through targeting DACT1 and activation of Wnt/β-catenin pathway in hepatocellular carcinoma.Liver stem cells and molecular signaling pathways in hepatocellular carcinoma.DACT1 overexpression inhibits proliferation, enhances apoptosis, and increases daunorubicin chemosensitivity in KG-1α cells.Dact gene expression profiles suggest a role for this gene family in integrating Wnt and TGF-β signaling pathways during chicken limb development.
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P2860
HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing
description
2005 nî lūn-bûn
@nan
2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing
@ast
HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing
@en
HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing
@en-gb
HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing
@nl
type
label
HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing
@ast
HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing
@en
HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing
@en-gb
HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing
@nl
prefLabel
HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing
@ast
HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing
@en
HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing
@en-gb
HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing
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HDPR1, a novel inhibitor of th ...... lation-mediated gene silencing
@en
P2093
Chun-Ming Wong
Chung-Yiu Chan
Kok-Lung Chan
Man-Fong Lee
Sheung-Tat Fan
Tai-On Yau
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P2888
P304
P3181
P356
10.1038/SJ.ONC.1208340
P407
P50
P577
2005-02-01T00:00:00Z
P5875
P6179
1026897949