Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo
about
Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of ParkinsonismThe H50Q mutation enhances α-synuclein aggregation, secretion, and toxicityc-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's diseaseDynamic structural flexibility of α-synucleinPhosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's diseaseDysregulation of autophagy and mitochondrial function in Parkinson's diseaseSynthetic Proteins and Peptides for the Direct Interrogation of α-Synuclein Posttranslational ModificationsPreventing the Androgen Receptor N/C Interaction Delays Disease Onset in a Mouse Model of SBMAMechanisms of Parkinson's disease-related proteins in mediating secondary brain damage after cerebral ischemia.Parkinson's disease-implicated kinases in the brain; insights into disease pathogenesis.Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates.Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneuronsInducible nitric oxide synthase is key to peroxynitrite-mediated, LPS-induced protein radical formation in murine microglial BV2 cells.Polo-like kinase 2 activates an antioxidant pathway to promote the survival of cells with mitochondrial dysfunction.The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells.Identification of the PLK2-dependent phosphopeptidome by quantitative proteomics [corrected].Curcumin Treatment Improves Motor Behavior in α-Synuclein Transgenic MicePhotobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease.Interaction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease.Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration.A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein.Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration.O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's diseaseToxic effects of human and rodent variants of alpha-synuclein in vivo.Formation and Implications of Alpha-Synuclein Radical in Maneb- and Paraquat-Induced Models of Parkinson's Disease.α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP.Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization.Silencing synuclein at the synapse with PLK2Presynaptic alpha-synuclein aggregation in a mouse model of Parkinson's disease.Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerationsAge-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice.Protein phosphorylation in neurodegeneration: friend or foe?Polo-like kinases: structural variations lead to multiple functions.Preoptic inputs and mechanisms that regulate maternal responsiveness.Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like PropagationA30P α-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network.Posttranslational Modifications and Clearing of α-Synuclein Aggregates in YeastSorting out release, uptake and processing of alpha-synuclein during prion-like spread of pathology.Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein.Therapeutic potential of autophagy-enhancing agents in Parkinson's disease.
P2860
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P2860
Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo
description
2013 nî lūn-bûn
@nan
2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Polo-like kinase 2 regulates s ...... uppresses its toxicity in vivo
@ast
Polo-like kinase 2 regulates s ...... uppresses its toxicity in vivo
@en
Polo-like kinase 2 regulates s ...... uppresses its toxicity in vivo
@en-gb
Polo-like kinase 2 regulates s ...... uppresses its toxicity in vivo
@nl
type
label
Polo-like kinase 2 regulates s ...... uppresses its toxicity in vivo
@ast
Polo-like kinase 2 regulates s ...... uppresses its toxicity in vivo
@en
Polo-like kinase 2 regulates s ...... uppresses its toxicity in vivo
@en-gb
Polo-like kinase 2 regulates s ...... uppresses its toxicity in vivo
@nl
prefLabel
Polo-like kinase 2 regulates s ...... uppresses its toxicity in vivo
@ast
Polo-like kinase 2 regulates s ...... uppresses its toxicity in vivo
@en
Polo-like kinase 2 regulates s ...... uppresses its toxicity in vivo
@en-gb
Polo-like kinase 2 regulates s ...... uppresses its toxicity in vivo
@nl
P2860
P921
P3181
P356
P1476
Polo-like kinase 2 regulates s ...... uppresses its toxicity in vivo
@en
P2093
Abid Oueslati
Patrick Aebischer
P2860
P304
P3181
P356
10.1073/PNAS.1309991110
P407
P577
2013-10-08T00:00:00Z