Molecular cloning and expression of GDP-D-mannose-4,6-dehydratase, a key enzyme for fucose metabolism defective in Lec13 cells
about
O-fucosylation is required for ADAMTS13 secretionThe glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylationStrain-promoted alkyne-azide cycloadditions (SPAAC) reveal new features of glycoconjugate biosynthesisFringe is a glycosyltransferase that modifies NotchTopological and functional characterization of WbpM, an inner membrane UDP-GlcNAc C6 dehydratase essential for lipopolysaccharide biosynthesis in Pseudomonas aeruginosaDevelopment and application of a salmonid EST database and cDNA microarray: data mining and interspecific hybridization characteristicsGlycomics profiling of Chinese hamster ovary cell glycosylation mutants reveals N-glycans of a novel size and complexity.Impairment of the Golgi GDP-L-fucose transport and unresponsiveness to fucose replacement therapy in LAD II patients.Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1In vitro biosynthesis and chemical identification of UDP-N-acetyl-d-quinovosamine (UDP-d-QuiNAc).Fucose: biosynthesis and biological function in mammals.Congenital disorders of glycosylation: glycosylation defects in man and biological models for their study.Mouse large can modify complex N- and mucin O-glycans on alpha-dystroglycan to induce laminin binding.Differential and cooperative polysialylation of the neural cell adhesion molecule by two polysialyltransferases, PST and STX.Biological function of fucosylation in cancer biology.Mutation of GDP-mannose-4,6-dehydratase in colorectal cancer metastasisFucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma.Model-based analysis of N-glycosylation in Chinese hamster ovary cells.In silico analysis of the fucosylation-associated genome of the human blood fluke Schistosoma mansoni: cloning and characterization of the enzymes involved in GDP-L-fucose synthesis and Golgi importOptimisation of the cellular metabolism of glycosylation for recombinant proteins produced by Mammalian cell systems.Production of therapeutic antibodies with controlled fucosylation.Fucosylation and gastrointestinal cancer.Roles of Pofut1 and O-fucose in mammalian Notch signaling.FX knockout CHO hosts can express desired ratios of fucosylated or afucosylated antibodies with high titers and comparable product quality.GDP-mannose-4,6-dehydratase is a cytosolic partner of tankyrase 1 that inhibits its poly(ADP-ribose) polymerase activity.GDP-mannose-4,6-dehydratase (GMDS) deficiency renders colon cancer cells resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor- and CD95-mediated apoptosis by inhibiting complex II formation.Inactivation of GDP-fucose transporter gene (Slc35c1) in CHO cells by ZFNs, TALENs and CRISPR-Cas9 for production of fucose-free antibodies.The GPI-linked Ly-6 antigen E48 regulates expression levels of the FX enzyme and of E-selectin ligands on head and neck squamous carcinoma cells.Structural and enzymatic characterization of human recombinant GDP-D-mannose-4,6-dehydratase.Inhibition of fucosylation by 2-fluorofucose suppresses human liver cancer HepG2 cell proliferation and migration as well as tumor formation.Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster.Cloning and expression of Helicobacter pylori GDP-l-fucose synthesizing enzymes (GMD and GMER) in Saccharomyces cerevisiae.Human Ly-6 antigen E48 (Ly-6D) regulates important interaction parameters between endothelial cells and head-and-neck squamous carcinoma cells.The GMD1 and GMD2 genes of Arabidopsis encode isoforms of GDP-D-mannose 4,6-dehydratase with cell type-specific expression patterns.Complex N-glycans are the major ligands for galectin-1, -3, and -8 on Chinese hamster ovary cells.GMDS dehydrates GDP-Man to GDP-DHDManFX enzyme and GDP-L-Fuc transporter expression in colorectal cancer.
P2860
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P2860
Molecular cloning and expression of GDP-D-mannose-4,6-dehydratase, a key enzyme for fucose metabolism defective in Lec13 cells
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Molecular cloning and expressi ...... olism defective in Lec13 cells
@ast
Molecular cloning and expressi ...... olism defective in Lec13 cells
@en
Molecular cloning and expressi ...... olism defective in Lec13 cells
@en-gb
Molecular cloning and expressi ...... olism defective in Lec13 cells
@nl
type
label
Molecular cloning and expressi ...... olism defective in Lec13 cells
@ast
Molecular cloning and expressi ...... olism defective in Lec13 cells
@en
Molecular cloning and expressi ...... olism defective in Lec13 cells
@en-gb
Molecular cloning and expressi ...... olism defective in Lec13 cells
@nl
prefLabel
Molecular cloning and expressi ...... olism defective in Lec13 cells
@ast
Molecular cloning and expressi ...... olism defective in Lec13 cells
@en
Molecular cloning and expressi ...... olism defective in Lec13 cells
@en-gb
Molecular cloning and expressi ...... olism defective in Lec13 cells
@nl
P2093
P2860
P356
P1476
Molecular cloning and expressi ...... olism defective in Lec13 cells
@en
P2093
P2860
P304
14582-14587
P356
10.1074/JBC.273.23.14582
P407
P577
1998-06-01T00:00:00Z