Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein
about
P1343
cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brainThe TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathwaysInsig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitroSterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteinsThe sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavageSecreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic miceLuman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysisProteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysinesThree mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasisDimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin betaCoexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surfaceA proteolytic pathway that controls the cholesterol content of membranes, cells, and bloodCholesterol through the looking glass: ability of its enantiomer also to elicit homeostatic responsesCholesterol feedback: from Schoenheimer's bottle to Scap's MELADLUnsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination stepA family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factorsSterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to InsigSterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteinsDual functions of Insig proteins in cholesterol homeostasisInverting the Topology of a Transmembrane Protein by Regulating the Translocation of the First Transmembrane HelixReconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and InsigsMembrane topology of human insig-1, a protein regulator of lipid synthesisTranscriptional regulation of the murine acetyl-CoA synthetase 1 gene through multiple clustered binding sites for sterol regulatory element-binding proteins and a single neighboring site for Sp1Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductaseAsparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 proteaseA role for smooth endoplasmic reticulum membrane cholesterol ester in determining the intracellular location and regulation of sterol-regulatory-element-binding protein-2Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteinsDistinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1cMaintaining cholesterol homeostasis: sterol regulatory element-binding proteinsCleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studiesPROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels.The gene-gene interaction of INSIG-SCAP-SREBP pathway on the risk of obesity in Chinese children.Identification of novel genes and pathways regulating SREBP transcriptional activityDevelopment of an accurate classification system of proteins into structured and unstructured regions that uncovers novel structural domains: its application to human transcription factors.Sequential actions of the AAA-ATPase valosin-containing protein (VCP)/p97 and the proteasome 19 S regulatory particle in sterol-accelerated, endoplasmic reticulum (ER)-associated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum.Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets.Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change.
P2860
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P2860
Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein
description
1997 nî lūn-bûn
@nan
1997 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
name
Identification of complexes be ...... BP cleavage-activating protein
@ast
Identification of complexes be ...... BP cleavage-activating protein
@en
Identification of complexes be ...... BP cleavage-activating protein
@en-gb
Identification of complexes be ...... BP cleavage-activating protein
@nl
type
label
Identification of complexes be ...... BP cleavage-activating protein
@ast
Identification of complexes be ...... BP cleavage-activating protein
@en
Identification of complexes be ...... BP cleavage-activating protein
@en-gb
Identification of complexes be ...... BP cleavage-activating protein
@nl
prefLabel
Identification of complexes be ...... BP cleavage-activating protein
@ast
Identification of complexes be ...... BP cleavage-activating protein
@en
Identification of complexes be ...... BP cleavage-activating protein
@en-gb
Identification of complexes be ...... BP cleavage-activating protein
@nl
P2093
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P1476
Identification of complexes be ...... BP cleavage-activating protein
@en
P2093
P2860
P304
P356
10.1074/JBC.272.32.20213
P407
P4510
P577
1997-08-08T00:00:00Z