about
Explaining oscillations and variability in the p53-Mdm2 systemGlycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activityA role for ATR in the DNA damage-induced phosphorylation of p53Characterization of an E1A-CBP interaction defines a novel transcriptional adapter motif (TRAM) in CBP/p300Involvement of protein kinase Cepsilon (PKCepsilon) in thyroid cell death. A truncated chimeric PKCepsilon cloned from a thyroid cancer cell line protects thyroid cells from apoptosisThe ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX proteinp53 regulation of G(2) checkpoint is retinoblastoma protein dependentMolecular epidemiological study of non-small-cell lung cancer from an environmentally polluted region of PolandPeptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cellsSuperinduction of CYP1A1 gene expression. Regulation of 2,3,7,8- tetrachlorodibenzo-p-dioxin-induced degradation of Ah receptor by cycloheximideCells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycleThe tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitinationStabilization and activation of p53 by the coactivator protein TAFII31The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradationProtein kinase CK2 is involved in G2 arrest and apoptosis following spindle damage in epithelial cellsHuman immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis.TRIAD1 inhibits MDM2-mediated p53 ubiquitination and degradationTurning the RING domain protein MdmX into an active ubiquitin-protein ligasePhosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligaseThe deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2USP10 regulates p53 localization and stability by deubiquitinating p53The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cellsCritical role for Daxx in regulating Mdm2RBB, a novel transcription repressor, represses the transcription of HDM2 oncogeneCamptothecin-induced downregulation of MLL5 contributes to the activation of tumor suppressor p53Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblastsPositive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradationTopors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53Identification and characterization of the novel protein CCDC106 that interacts with p53 and promotes its degradationStra13 is induced by genotoxic stress and regulates ionizing-radiation-induced apoptosisGlioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressorCharacterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1HDM2-binding partners: interaction with translation elongation factor EF1alpha.A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosisMDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosisHLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis
P2860
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P2860
description
1997 nî lūn-bûn
@nan
1997 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Mdm2 promotes the rapid degradation of p53
@ast
Mdm2 promotes the rapid degradation of p53
@en
Mdm2 promotes the rapid degradation of p53
@en-gb
Mdm2 promotes the rapid degradation of p53
@nl
type
label
Mdm2 promotes the rapid degradation of p53
@ast
Mdm2 promotes the rapid degradation of p53
@en
Mdm2 promotes the rapid degradation of p53
@en-gb
Mdm2 promotes the rapid degradation of p53
@nl
prefLabel
Mdm2 promotes the rapid degradation of p53
@ast
Mdm2 promotes the rapid degradation of p53
@en
Mdm2 promotes the rapid degradation of p53
@en-gb
Mdm2 promotes the rapid degradation of p53
@nl
P2093
P3181
P356
P1433
P1476
Mdm2 promotes the rapid degradation of p53
@en
P2093
P2888
P3181
P356
10.1038/387296A0
P407
P577
1997-05-15T00:00:00Z
P5875
P6179
1004301257