Cooperative interactions at the SLP-76 complex are critical for actin polymerization
about
Ubiquitylation-dependent downregulation of Nck regulates its functional activitySequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cellsWIP remodeling actin behind the scenes: how WIP reshapes immune and other functionsSuper-resolution characterization of TCR-dependent signaling clustersMolecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapseVav family exchange factors: an integrated regulatory and functional viewWASp family verprolin-homologous protein-2 (WAVE2) and Wiskott-Aldrich syndrome protein (WASp) engage in distinct downstream signaling interactions at the T cell antigen receptor siteHierarchical nanostructure and synergy of multimolecular signalling complexes.Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalizationSH3 domains: modules of protein-protein interactions.Grb2 carboxyl-terminal SH3 domain can bivalently associate with two ligands, in an SH3 dependent manner.T cell specific adaptor protein (TSAd) promotes interaction of Nck with Lck and SLP-76 in T cells.The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms.Direct regulation of nephrin tyrosine phosphorylation by Nck adaptor proteins.Mechanism and function of Vav1 localisation in TCR signalling.Stoichiometry of Nck-dependent actin polymerization in living cellsStudies of novel interactions between Nck and VAV SH3 domains.Functional cooperation between the proteins Nck and ADAP is fundamental for actin reorganization.Ubiquitylation-dependent negative regulation of WASp is essential for actin cytoskeleton dynamicsSpatial association of signaling proteins and F-actin effects on cluster assembly analyzed via photoactivation localization microscopy in T cellsAccounting for photophysical processes and specific signal intensity changes in fluorescence-detected sedimentation velocityStrategies for assessing proton linkage to bimolecular interactions by global analysis of isothermal titration calorimetry dataNon-catalytic functions of Pyk2 and Fyn regulate late stage adhesion in human T cells.Multi-signal sedimentation velocity analysis with mass conservation for determining the stoichiometry of protein complexes.Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments.The boundary structure in the analysis of reversibly interacting systems by sedimentation velocity.Combining biophysical methods for the analysis of protein complex stoichiometry and affinity in SEDPHAT.GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cellsEvaluating the stoichiometry of macromolecular complexes using multisignal sedimentation velocity.Immune synapse: conductor of orchestrated organelle movement.Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor.Imaging techniques for assaying lymphocyte activation in action.Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines.Overview of current methods in sedimentation velocity and sedimentation equilibrium analytical ultracentrifugation.Signaling clusters in the cell membrane.Monochromatic multicomponent fluorescence sedimentation velocity for the study of high-affinity protein interactions.SLP-76 sterile α motif (SAM) and individual H5 α helix mediate oligomer formation for microclusters and T-cell activation.Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells.Coordinate control of cytoskeletal remodeling and calcium mobilization during T-cell activationComplementary phosphorylation sites in the adaptor protein SLP-76 promote synergistic activation of natural killer cells
P2860
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P2860
Cooperative interactions at the SLP-76 complex are critical for actin polymerization
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Cooperative interactions at the SLP-76 complex are critical for actin polymerization
@ast
Cooperative interactions at the SLP-76 complex are critical for actin polymerization
@en
Cooperative interactions at the SLP-76 complex are critical for actin polymerization
@en-gb
Cooperative interactions at the SLP-76 complex are critical for actin polymerization
@nl
type
label
Cooperative interactions at the SLP-76 complex are critical for actin polymerization
@ast
Cooperative interactions at the SLP-76 complex are critical for actin polymerization
@en
Cooperative interactions at the SLP-76 complex are critical for actin polymerization
@en-gb
Cooperative interactions at the SLP-76 complex are critical for actin polymerization
@nl
prefLabel
Cooperative interactions at the SLP-76 complex are critical for actin polymerization
@ast
Cooperative interactions at the SLP-76 complex are critical for actin polymerization
@en
Cooperative interactions at the SLP-76 complex are critical for actin polymerization
@en-gb
Cooperative interactions at the SLP-76 complex are critical for actin polymerization
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Cooperative interactions at the SLP-76 complex are critical for actin polymerization
@en
P2093
Andrea Balbo
Hiroshi Yamaguchi
Jon C D Houtman
Lawrence E Samelson
Maor H Pauker
Naoto Shirasu
Nirit Hassan
P2860
P304
P3181
P356
10.1038/EMBOJ.2010.133
P407
P577
2010-07-21T00:00:00Z