Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis
about
The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2The Gas6/TAM System and Multiple SclerosisProtein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like regionPolymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibilityGAS6 enhances repair following cuprizone-induced demyelination.Immunobiology of the TAM receptors.Gas6 increases myelination by oligodendrocytes and its deficiency delays recovery following cuprizone-induced demyelinationProtein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor.In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation.TAM receptor tyrosine kinases: expression, disease and oncogenesis in the central nervous system.Growth arrest-specific protein 6 is hepatoprotective against murine ischemia/reperfusion injury.Regulation of phagocytosis by TAM receptors and their ligands.Involvement of receptor tyrosine kinase Tyro3 in amyloidogenic APP processing and β-amyloid deposition in Alzheimer's disease models.Targeted GAS6 delivery to the CNS protects axons from damage during experimental autoimmune encephalomyelitisTAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer.Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity.TAM receptor deficiency affects adult hippocampal neurogenesis.Gas6 enhances axonal ensheathment by MBP+ membranous processes in human DRG/OL promyelinating co-culturesTAM receptor signaling in immune homeostasis.CXCR2 signaling and host defense following coronavirus-induced encephalomyelitis.Combined inhibition of AXL, Lyn and p130Cas kinases block migration of triple negative breast cancer cells.Protein kinase C-dependent control of Bcl-x alternative splicing.Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancerLocalization and signaling of the receptor protein tyrosine kinase Tyro3 in cortical and hippocampal neurons.Vitamin K and the nervous system: an overview of its actions.Growth arrest specific gene 6 protein concentration in cerebrospinal fluid correlates with relapse severity in multiple sclerosis.Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple sclerosis lesionsGrowth arrest-specific protein 6 attenuates neutrophil migration and acute lung injury in sepsisGas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination.Sexual dimorphism of oligodendrocytes is mediated by differential regulation of signaling pathways.Vitamin K, an emerging nutrient in brain function.Agents in the preclinical development stage for non-small cell lung cancer.Role of AXL expression in non-small cell lung cancer.Gene of the month: Axl.Receptor tyrosine kinase Axl is required for resistance of leukemic cells to FLT3-targeted therapy in acute myeloid leukemia.TRAIL and Taurolidine induce apoptosis and decrease proliferation in human fibrosarcoma.Protective Effects of Growth Arrest-Specific Protein 6 (Gas6) on Sepsis-Induced Acute Kidney Injury.Tumor-associated macrophages promote oral cancer progression through activation of the Axl signaling pathway.Regulation of granulosa and theca cell transcriptomes during ovarian antral follicle development.Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-kappaB transcriptional activat
P2860
Q24294260-F25566E6-4D5F-4FAB-9775-C7A09392003DQ28067131-56EB449D-4181-4C61-B576-AD72F1382F18Q28592005-F6D73AFB-06D0-4EA2-B104-FA61C3D10C9CQ28742974-52966DA3-A74E-42D9-B7E7-5DFD239B082DQ33784396-4200A171-0515-476E-91B5-5FF6EE2BF02EQ33796991-FD026299-9F49-4937-B989-15E0A88F26C1Q33851531-BCE24A05-6ACB-477A-8571-3D984D33AAE7Q33931826-77076D06-AC23-42E4-BE6C-27229A399075Q33999355-6B9DEE8B-C046-48A2-B96F-2C755D2397ABQ34077622-D2ADDB05-AAC5-48F9-869D-A51DC7A87BA5Q34163837-272E5868-C375-41A3-859A-12EB93D71393Q34271347-CE1FAAA4-59F3-4DAA-AA13-4D504B0D2933Q34305878-8C697C42-ED9D-4101-92AF-3F036D304A49Q34614563-2E227F4A-DFF6-4F41-8D45-B3303E48311AQ34794927-2E0D4D8E-4EFB-4A09-939B-0BCCC5DB58ADQ35111750-76B86100-C0C5-407B-A84B-D48163AD02D7Q35553941-BF8144B5-9B82-4A56-AC7B-22756EECF991Q35559678-D0C00F59-4566-4166-ACC3-6A61391DBB1AQ35819380-9541538A-2FFB-44A0-AE82-CB509B67D0EFQ35947646-9561D232-400A-469D-A0EC-9E8B445CA4E5Q36214760-22A892FA-BDFC-4AA9-86D7-310F1DA6170CQ36316498-8AE8E9C9-4A0D-4A82-9951-F44717039256Q36413157-70887DD0-1B24-486E-8575-B9810B65828FQ36439979-56041363-7632-4B24-80EB-9C08040492C1Q36828729-1BCFBA2F-A4F2-40B1-A07C-C57DFAE92665Q36918304-5DAB10E2-A1A6-452F-A2CF-323329891641Q37257176-049128CB-2848-427B-8888-FD72DFC6833BQ37325341-4EFE8A35-7904-4305-B49D-CE3BB8BABC19Q37352392-2CAA4A08-A208-45DA-A486-8072CD105E63Q37384462-4D7F968D-FE20-412A-927A-9577B4B6947FQ37993819-6C2DC0BD-1B3B-4CE8-A79B-A1D6527E69D4Q38612204-B7A54CA2-8EE7-46CC-A082-1CD3DD524C4EQ38720434-5A9F45FC-F328-4CCA-9892-228E657317F5Q38763966-2046C476-B273-4F66-A07A-990FA358BC6BQ38853220-013D0574-ACEB-4F8D-824F-76C728A04DFAQ39905680-79A9E0E6-4179-410A-B0BA-AAB59A0E4F9AQ40340264-DFF8C004-B854-4784-A6F4-367CAD0578ECQ44448373-88770A8B-BF9B-4F85-83B9-63F732A0D6DFQ46742876-106B01D7-E0F3-467E-A2B0-D2A3D1564624Q46881381-FFCD5721-3FBB-4D00-8BDF-25F0E9E5B46A
P2860
Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis
description
2006 nî lūn-bûn
@nan
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Gas6/Axl signaling activates t ...... factor alpha-induced apoptosis
@ast
Gas6/Axl signaling activates t ...... factor alpha-induced apoptosis
@en
Gas6/Axl signaling activates t ...... factor alpha-induced apoptosis
@en-gb
Gas6/Axl signaling activates t ...... factor alpha-induced apoptosis
@nl
type
label
Gas6/Axl signaling activates t ...... factor alpha-induced apoptosis
@ast
Gas6/Axl signaling activates t ...... factor alpha-induced apoptosis
@en
Gas6/Axl signaling activates t ...... factor alpha-induced apoptosis
@en-gb
Gas6/Axl signaling activates t ...... factor alpha-induced apoptosis
@nl
prefLabel
Gas6/Axl signaling activates t ...... factor alpha-induced apoptosis
@ast
Gas6/Axl signaling activates t ...... factor alpha-induced apoptosis
@en
Gas6/Axl signaling activates t ...... factor alpha-induced apoptosis
@en-gb
Gas6/Axl signaling activates t ...... factor alpha-induced apoptosis
@nl
P2093
P921
P1476
Gas6/Axl signaling activates t ...... factor alpha-induced apoptosis
@en
P2093
Brian Varnum
Bridget Shafit-Zagardo
Celia F Brosnan
Greg Lemke
Kathleen O'Guin
Sai Latha Shankar
P304
P356
10.1523/JNEUROSCI.5063-05.2006
P407
P577
2006-05-01T00:00:00Z