Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid - sprookjes - yvandenbroek - TriplyDB

Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid

Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid

http://www.wikidata.org/entity/Q24530352

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Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial Mitochondrial modulators for bipolar disorder: A pathophysiologically informed paradigm for new drug development Long-Term Potentiation and Memory Alpha lipoic acid for dementia Novel therapeutics for Alzheimer's disease: an update Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential Cognitive Aging and Time Perception: Roles of Bayesian Optimization and Degeneracy Marine Carotenoids against Oxidative Stress: Effects on Human Health Transcriptional mutagenesis by 8-oxodG in α-synuclein aggregation and the pathogenesis of Parkinson's disease Biology of ageing and role of dietary antioxidants Metabolomics of human brain aging and age-related neurodegenerative diseases Mechanisms of chemotherapy-induced behavioral toxicities Metabolic disturbances in diseases with neurological involvement Neuronal failure in Alzheimer's disease: a view through the oxidative stress looking-glass Reduced adolescent-age spatial learning ability associated with elevated juvenile-age superoxide levels in complex I mouse mutants Flavonoid derivative 7,8-DHF attenuates TBI pathology via TrkB activation.Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy Loss of taste responds to high-dose biotin treatment.Coenzyme Q10 and α-tocopherol reversed age-associated functional impairments in mice.N-acetyl cysteine treatment rescues cognitive deficits induced by mitochondrial dysfunction in G72/G30 transgenic mice Protective effects of sodium para-amino salicylate on manganese-induced neuronal death: the involvement of reactive oxygen species.Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging Mitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behavior Age and gender dependent bioavailability of R- and R,S-α-lipoic acid: a pilot study.alpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling in the skeletal muscle of aged mice.Are ancient proteins responsible for the age-related decline in health and fitness?Mitochondria in the elderly: Is acetylcarnitine a rejuvenator?Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress.Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid.Mitochondrial dynamics in Alzheimer's disease: opportunities for future treatment strategies.n-3 polyunsaturated fatty acids supplementation enhances hippocampal functionality in aged mice.Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart Prevention of mutation, cancer, and other age-associated diseases by optimizing micronutrient intake.An enthusiasm for metabolism.Mitochondria and neuroplasticity.Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid.Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimer's disease.A nutraceutical a day may keep the doctor away. Consumers are turning increasingly to food supplements to improve well-being when pharmaceuticals fail.Increasing longevity by tuning up metabolism. To maximize human health and lifespan, scientists must abandon outdated models of micronutrients.

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P2860

Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid

http://www.wikidata.org/entity/Q24530352

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2002 nî lūn-bûn

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2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2002 թվականի փետրվարին հրատարակված գիտական հոդված

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2002年の論文

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Memory loss in old rats is ass ...... ne and/or R-alpha -lipoic acid

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Proceedings of the National Academy of Sciences of the United States of America

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Afshin M Gharib

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Bruce N Ames

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Carl W Cotman

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Elizabeth Head

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Jiankang Liu

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Russell T Ingersoll

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Tory M Hagen

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Wenjun Yuan

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P2860

Oxidants, antioxidants, and the degenerative diseases of aging

Developments of a water-maze procedure for studying spatial learning in the rat

A review of nutrients and botanicals in the integrative management of cognitive dysfunction.

Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation.

Protein oxidation.

Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress.

Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid.

Neuroprotection by the metabolic antioxidant alpha-lipoic acid.

In search of molecular memory: experience-driven protein synthesis.

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2356-2361

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10.1073/PNAS.261709299

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4

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99

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11854529

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