Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid
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Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trialMitochondrial modulators for bipolar disorder: A pathophysiologically informed paradigm for new drug developmentLong-Term Potentiation and MemoryAlpha lipoic acid for dementiaNovel therapeutics for Alzheimer's disease: an updateAlpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potentialCognitive Aging and Time Perception: Roles of Bayesian Optimization and DegeneracyMarine Carotenoids against Oxidative Stress: Effects on Human HealthTranscriptional mutagenesis by 8-oxodG in α-synuclein aggregation and the pathogenesis of Parkinson's diseaseBiology of ageing and role of dietary antioxidantsMetabolomics of human brain aging and age-related neurodegenerative diseasesMechanisms of chemotherapy-induced behavioral toxicitiesMetabolic disturbances in diseases with neurological involvementNeuronal failure in Alzheimer's disease: a view through the oxidative stress looking-glassReduced adolescent-age spatial learning ability associated with elevated juvenile-age superoxide levels in complex I mouse mutantsFlavonoid derivative 7,8-DHF attenuates TBI pathology via TrkB activation.Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human agingIncreased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophyLoss of taste responds to high-dose biotin treatment.Coenzyme Q10 and α-tocopherol reversed age-associated functional impairments in mice.N-acetyl cysteine treatment rescues cognitive deficits induced by mitochondrial dysfunction in G72/G30 transgenic miceProtective effects of sodium para-amino salicylate on manganese-induced neuronal death: the involvement of reactive oxygen species.Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with agingMitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behaviorAge and gender dependent bioavailability of R- and R,S-α-lipoic acid: a pilot study.alpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling in the skeletal muscle of aged mice.Are ancient proteins responsible for the age-related decline in health and fitness?Mitochondria in the elderly: Is acetylcarnitine a rejuvenator?Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress.Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid.Mitochondrial dynamics in Alzheimer's disease: opportunities for future treatment strategies.n-3 polyunsaturated fatty acids supplementation enhances hippocampal functionality in aged mice.Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heartPrevention of mutation, cancer, and other age-associated diseases by optimizing micronutrient intake.An enthusiasm for metabolism.Mitochondria and neuroplasticity.Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid.Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimer's disease.A nutraceutical a day may keep the doctor away. Consumers are turning increasingly to food supplements to improve well-being when pharmaceuticals fail.Increasing longevity by tuning up metabolism. To maximize human health and lifespan, scientists must abandon outdated models of micronutrients.
P2860
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P2860
Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid
description
2002 nî lūn-bûn
@nan
2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
name
Memory loss in old rats is ass ...... ne and/or R-alpha -lipoic acid
@ast
Memory loss in old rats is ass ...... ne and/or R-alpha -lipoic acid
@en
Memory loss in old rats is ass ...... ne and/or R-alpha -lipoic acid
@en-gb
Memory loss in old rats is ass ...... ne and/or R-alpha -lipoic acid
@nl
type
label
Memory loss in old rats is ass ...... ne and/or R-alpha -lipoic acid
@ast
Memory loss in old rats is ass ...... ne and/or R-alpha -lipoic acid
@en
Memory loss in old rats is ass ...... ne and/or R-alpha -lipoic acid
@en-gb
Memory loss in old rats is ass ...... ne and/or R-alpha -lipoic acid
@nl
prefLabel
Memory loss in old rats is ass ...... ne and/or R-alpha -lipoic acid
@ast
Memory loss in old rats is ass ...... ne and/or R-alpha -lipoic acid
@en
Memory loss in old rats is ass ...... ne and/or R-alpha -lipoic acid
@en-gb
Memory loss in old rats is ass ...... ne and/or R-alpha -lipoic acid
@nl
P2093
P2860
P3181
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P1476
Memory loss in old rats is ass ...... ne and/or R-alpha -lipoic acid
@en
P2093
Afshin M Gharib
Bruce N Ames
Carl W Cotman
Elizabeth Head
Jiankang Liu
Russell T Ingersoll
Tory M Hagen
Wenjun Yuan
P2860
P304
P3181
P356
10.1073/PNAS.261709299
P407
P577
2002-02-01T00:00:00Z