Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase - sprookjes - yvandenbroek - TriplyDB

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

http://www.wikidata.org/entity/Q24531326

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Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling The PI3K pathway as drug target in human cancer Insulin receptor signaling in normal and insulin-resistant states Phosphoinositide-3 Kinase-Akt Pathway Controls Cellular Entry of Ebola Virus The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis.Essential role for the p110delta phosphoinositide 3-kinase in the allergic response Negative regulators of insulin signaling revealed in a genome-wide functional screen Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation p85α mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase.Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement A PI3K activity-independent function of p85 regulatory subunit in control of mammalian cytokinesis.Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation.Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha.Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice.Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training.Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy.Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth Impairment of vesicular ATP release affects glucose metabolism and increases insulin sensitivity.p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity.Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance.Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance.Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.Dicer-1-dependent Dacapo suppression acts downstream of Insulin receptor in regulating cell division of Drosophila germline stem cells Lipid phosphatases in the regulation of T cell activation: living up to their PTEN-tial.Molecular characterization of the peripheral airway field of cancerization in lung adenocarcinoma.Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models.BMP2-induced chemotaxis requires PI3K p55γ/p110α-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5β recruitment at the cytocortex The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling.Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85alpha Site and mechanism of leptin action in a rodent form of congenital lipodystrophy Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers.

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Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

http://www.wikidata.org/entity/Q24531326

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2002 nî lūn-bûn

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2002 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2002 թվականի հունվարին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年论文

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name

Increased insulin sensitivity ...... t of phosphoinositide 3-kinase

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Increased insulin sensitivity ...... t of phosphoinositide 3-kinase

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Increased insulin sensitivity ...... t of phosphoinositide 3-kinase

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Increased insulin sensitivity ...... t of phosphoinositide 3-kinase

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Increased insulin sensitivity ...... t of phosphoinositide 3-kinase

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Increased insulin sensitivity ...... t of phosphoinositide 3-kinase

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Increased insulin sensitivity ...... t of phosphoinositide 3-kinase

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Increased insulin sensitivity ...... t of phosphoinositide 3-kinase

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Increased insulin sensitivity ...... t of phosphoinositide 3-kinase

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Increased insulin sensitivity ...... t of phosphoinositide 3-kinase

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Increased insulin sensitivity ...... t of phosphoinositide 3-kinase

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Increased insulin sensitivity ...... t of phosphoinositide 3-kinase

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Proceedings of the National Academy of Sciences of the United States of America

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Increased insulin sensitivity ...... t of phosphoinositide 3-kinase

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Claudine M Yballe

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David Vicent

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John M Watt

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Saskia M Brachmann

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Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes

Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1

Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

SH2 domains recognize specific phosphopeptide sequences

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl

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419-24

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scholarly article

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2882819

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10.1073/PNAS.012581799

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1

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99

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Lewis C. Cantley

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2002-01-08T00:00:00Z

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11605723

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11752399

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