Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres
about
Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functionsComposition and histone substrates of polycomb repressive group complexes change during cellular differentiationCharacterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes.Association of SET domain and myotubularin-related proteins modulates growth controlTwo distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivatorsInteraction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes.Point mutations in the WD40 domain of Eed block its interaction with Ezh2.The Drosophila esc and E(z) proteins are direct partners in polycomb group-mediated repression.The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression.HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressorThe Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classesEZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotencyMetabolomic profiles delineate potential role for sarcosine in prostate cancer progressionSet9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation.EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cellsHistone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste proteinThe quest for mammalian Polycomb response elements: are we there yet?Epigenetic inheritance: histone bookmarks across generationsStructural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET DomainRecurrent DNMT3A mutations in patients with myelodysplastic syndromesSET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes.Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste proteinThe Polycomb group protein EZH2 impairs DNA repair in breast epithelial cellsHistone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae.The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiationEzh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cellsEZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomasThe polycomb group protein EZH2 is involved in progression of prostate cancerThe polycomb-group gene Ezh2 is required for early mouse developmentRNAi-dependent H3K27 methylation is required for heterochromatin formation and DNA elimination in Tetrahymena.A silencer element identified in Drosophila is required for imprinting of H19 reporter transgenes in mice.Remarkable compartmentalization of transposable elements and pseudogenes in the heterochromatin of the Tetraodon nigroviridis genome.High-resolution mapping reveals links of HP1 with active and inactive chromatin components.Expression of polycomb group protein EZH2 in nevi and melanoma.Molecular architecture of polycomb repressive complexesPHF1 Tudor and N-terminal domains synergistically target partially unwrapped nucleosomes to increase DNA accessibilityComprehensive evaluation of the role of EZH2 in the growth, invasion, and aggression of a panel of prostate cancer cell linesEBNA-1: a protein pivotal to latent infection by Epstein-Barr virus.
P2860
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P2860
Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
name
Mammalian homologues of the Po ...... and at S. cerevisiae telomeres
@ast
Mammalian homologues of the Po ...... and at S. cerevisiae telomeres
@en
Mammalian homologues of the Po ...... and at S. cerevisiae telomeres
@en-gb
Mammalian homologues of the Po ...... and at S. cerevisiae telomeres
@nl
type
label
Mammalian homologues of the Po ...... and at S. cerevisiae telomeres
@ast
Mammalian homologues of the Po ...... and at S. cerevisiae telomeres
@en
Mammalian homologues of the Po ...... and at S. cerevisiae telomeres
@en-gb
Mammalian homologues of the Po ...... and at S. cerevisiae telomeres
@nl
prefLabel
Mammalian homologues of the Po ...... and at S. cerevisiae telomeres
@ast
Mammalian homologues of the Po ...... and at S. cerevisiae telomeres
@en
Mammalian homologues of the Po ...... and at S. cerevisiae telomeres
@en-gb
Mammalian homologues of the Po ...... and at S. cerevisiae telomeres
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
Mammalian homologues of the Po ...... and at S. cerevisiae telomeres
@en
P2093
A Lebersorger
T Jenuwein
P2860
P304
P3181
P356
10.1093/EMBOJ/16.11.3219
P407
P577
1997-06-01T00:00:00Z