Evidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammals
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Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent intronsThe human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 proteinHuman step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicingPhosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysisHuman homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicingA potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch sitePrp8 protein: at the heart of the spliceosomeThe C-terminal region of hPrp8 interacts with the conserved GU dinucleotide at the 5' splice siteThe human Prp8 protein is a component of both U2- and U12-dependent spliceosomesPSF and p54nrb bind a conserved stem in U5 snRNAAn upstream AG determines whether a downstream AG is selected during catalytic step II of splicingPre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctionsU2AF homology motifs: protein recognition in the RRM worldBiased exon/intron distribution of cryptic and de novo 3' splice sitesOrigin and evolution of spliceosomal intronsSynthetic lethality of yeast slt mutations with U2 small nuclear RNA mutations suggests functional interactions between U2 and U5 snRNPs that are important for both steps of pre-mRNA splicing.Nucleocytoplasmic shuttling of heterodimeric splicing factor U2AFATP-dependent interaction of yeast U5 snRNA loop 1 with the 5' splice site.Polypyrimidine tract binding protein functions as a repressor to regulate alternative splicing of alpha-actinin mutally exclusive exonsA general approach for identification of RNA-protein cross-linking sites within native human spliceosomal small nuclear ribonucleoproteins (snRNPs). Analysis of RNA-protein contacts in native U1 and U4/U6.U5 snRNPs.Analysis of RNA splicing defects in PITX2 mutants supports a gene dosage model of Axenfeld-Rieger syndrome.Signal-regulated Pre-mRNA occupancy by the general splicing factor U2AF.Origin of spliceosomal introns and alternative splicingThe RNA splicing factor hSlu7 is required for correct 3' splice-site choice.Functional analysis of the U5 snRNA loop 1 in the second catalytic step of yeast pre-mRNA splicing.Conserved loop I of U5 small nuclear RNA is dispensable for both catalytic steps of pre-mRNA splicing in HeLa nuclear extracts.Switch in 3' splice site recognition between exon definition and splicing catalysis is important for sex-lethal autoregulation.Proximity of the invariant loop of U5 snRNA to the second intron residue during pre-mRNA splicing.A flexible RNA backbone within the polypyrimidine tract is required for U2AF65 binding and pre-mRNA splicing in vivoSpliceosomal snRNA modifications and their function.Genetic interactions between the 5' and 3' splice site consensus sequences and U6 snRNA during the second catalytic step of pre-mRNA splicing.An artificial riboswitch for controlling pre-mRNA splicing.Characterization of newly gained introns in Daphnia populations.A protein-based EM label for RNA identifies the location of exons in spliceosomes.Evidence for a linear search in bimolecular 3' splice site AG selection.Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome.Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center.Two common forms of the human MLH1 gene may be associated with functional differencesMultiple U2AF65 binding sites within SF3b155: thermodynamic and spectroscopic characterization of protein-protein interactions among pre-mRNA splicing factors.TEG-1 CD2BP2 regulates stem cell proliferation and sex determination in the C. elegans germ line and physically interacts with the UAF-1 U2AF65 splicing factor
P2860
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P2860
Evidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammals
description
1997 nî lūn-bûn
@nan
1997 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
name
Evidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammals
@ast
Evidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammals
@en
Evidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammals
@en-gb
Evidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammals
@nl
type
label
Evidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammals
@ast
Evidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammals
@en
Evidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammals
@en-gb
Evidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammals
@nl
prefLabel
Evidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammals
@ast
Evidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammals
@en
Evidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammals
@en-gb
Evidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammals
@nl
P2093
P2860
P356
P1433
P1476
Evidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammals
@en
P2093
L Palandjian
M D Chiara
R Feld Kramer
P2860
P304
P356
10.1093/EMBOJ/16.15.4746
P407
P577
1997-08-01T00:00:00Z