The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.
about
A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetlesGenetics of zwittermicin a production by Bacillus cereusRole of trastuzumab emtansine in the treatment of HER2-positive breast cancerRecent advances in the development of anti-HER2 antibodies and antibody-drug conjugatesA self-sufficient cytochrome p450 with a primary structural organization that includes a flavin domain and a [2Fe-2S] redox centerTowards prediction of metabolic products of polyketide synthases: an in silico analysisComputational approaches to natural product discoveryPCR screening reveals considerable unexploited biosynthetic potential of ansamycins and a mysterious family of AHBA-containing natural products in actinomycetes.Unprecedented diversity of catalytic domains in the first four modules of the putative pederin polyketide synthase.Combinatorial biosynthesis--potential and problems.An integrative expression vector for Actinosynnema pretiosum.Enriching plant microbiota for a metagenomic library construction.Formation and characterization of acyl carrier protein-linked polyketide synthase extender units.Recognition of (2S)-aminomalonyl-acyl carrier protein (ACP) and (2R)-hydroxymalonyl-ACP by acyltransferases in zwittermicin A biosynthesisCharacterization of the tunicamycin gene cluster unveiling unique steps involved in its biosynthesis.Interpreting Microbial Biosynthesis in the Genomic Age: Biological and Practical Considerations.Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplificationInsights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption.Oxazolomycin biosynthesis in Streptomyces albus JA3453 featuring an "acyltransferase-less" type I polyketide synthase that incorporates two distinct extender unitsBiochemical and genetic insights into asukamycin biosynthesis.The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library.Aminobenzoates as building blocks for natural product assembly lines.Insights into an unusual nonribosomal peptide synthetase biosynthesis: identification and characterization of the GE81112 biosynthetic gene cluster.Biosynthesis of 3,5-AHBA-derived natural products.Evolutionary divergence of sedoheptulose 7-phosphate cyclases leads to several distinct cyclic products.Tapping into microbial diversity.Tramadol--a true natural product?Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus.Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning the oxazolomycin biosynthetic gene cluster from Streptomyces albus JA3453The biosynthetic genes encoding for the production of the dynemicin enediyne core in Micromonospora chersina ATCC53710Characterization of the polyoxin biosynthetic gene cluster from Streptomyces cacaoi and engineered production of polyoxin HA comparative analysis of the sugar phosphate cyclase superfamily involved in primary and secondary metabolismStreptomyces genetics: a genomic perspective.The enzymology of combinatorial biosynthesis.Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli.A streamlined metabolic pathway for the biosynthesis of moenomycin A.Bioprospecting potential of halogenases from Arctic marine actinomycetes.N-methylation of the amide bond by methyltransferase asm10 in ansamitocin biosynthesisCombinatorial biosynthesis of reduced polyketides.Proteomic studies on anti-tumor agent ansamitocin P-3 producer Actinosynnema pretiosum in response to ammonium and isobutanol.
P2860
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P2860
The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The biosynthetic gene cluster ...... n from Actinosynnema pretiosum
@nl
The biosynthetic gene cluster ...... from Actinosynnema pretiosum.
@ast
The biosynthetic gene cluster ...... from Actinosynnema pretiosum.
@en
The biosynthetic gene cluster ...... from Actinosynnema pretiosum.
@en-gb
type
label
The biosynthetic gene cluster ...... n from Actinosynnema pretiosum
@nl
The biosynthetic gene cluster ...... from Actinosynnema pretiosum.
@ast
The biosynthetic gene cluster ...... from Actinosynnema pretiosum.
@en
The biosynthetic gene cluster ...... from Actinosynnema pretiosum.
@en-gb
prefLabel
The biosynthetic gene cluster ...... n from Actinosynnema pretiosum
@nl
The biosynthetic gene cluster ...... from Actinosynnema pretiosum.
@ast
The biosynthetic gene cluster ...... from Actinosynnema pretiosum.
@en
The biosynthetic gene cluster ...... from Actinosynnema pretiosum.
@en-gb
P2093
P2860
P356
P1476
The biosynthetic gene cluster ...... from Actinosynnema pretiosum.
@en
P2093
Dietmar Hoffmann
Dorothee Clade
Eckhard Leistner
Heinz G Floss
Khue Q Trinh
Linquan Bai
Sabine Toelzer
Steven J Moss
Tin-Wein Yu
P2860
P304
P356
10.1073/PNAS.092697199
P407
P577
2002-06-01T00:00:00Z