The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin.
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Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancerSynergistic antileukemic interactions between 2-medroxyestradiol (2-ME) and histone deacetylase inhibitors involve Akt down-regulation and oxidative stressChe-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoterhnRNP G elicits tumor-suppressive activity in part by upregulating the expression of TxnipNeuroblastoma-derived secretory protein is a novel secreted factor overexpressed in neuroblastomaThioredoxin-binding protein-2 (TBP-2/VDUP1/TXNIP) regulates T-cell sensitivity to glucocorticoid during HTLV-I-induced transformationVitamin D3 up-regulated protein 1(VDUP1) is regulated by FOXO3A and miR-17-5p at the transcriptional and post-transcriptional levels, respectively, in senescent fibroblastsThe histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responsesCancer Stem Cells: The Potential Targets of Chinese Medicines and Their Active CompoundsCancer stem cells: a metastasizing menace!Targeting histone deacetylases for cancer therapy: from molecular mechanisms to clinical implicationsThioredoxin/Txnip: redoxisome, as a redox switch for the pathogenesis of diseasesMechanisms of Histone Deacetylase Inhibitor-Regulated Gene Expression in Cancer CellsThe structural basis for the negative regulation of thioredoxin by thioredoxin-interacting proteinAcetylation Reader Proteins: Linking Acetylation Signaling to Genome Maintenance and CancerEpigenetics in Brain Tumors: HDACs Take Center StageAdvancements in the delivery of epigenetic drugsVDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progressionImportin alpha1 (Rch1) mediates nuclear translocation of thioredoxin-binding protein-2/vitamin D(3)-up-regulated protein 1Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drugOvercoming resistance to histone deacetylase inhibitors in human leukemia with the redox modulating compound β-phenylethyl isothiocyanateThe cysteine proteomeGene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancerTrichostatin A targets the mitochondrial respiratory chain, increasing mitochondrial reactive oxygen species production to trigger apoptosis in human breast cancer cellsOvercoming Resistance of Cancer Cells to PARP-1 Inhibitors with Three Different Drug CombinationsTwo distinct mechanisms for loss of thioredoxin-binding protein-2 in oxidative stress-induced renal carcinogenesisAcetylation of retinal histones in diabetes increases inflammatory proteins: effects of minocycline and manipulation of histone acetyltransferase (HAT) and histone deacetylase (HDAC)Preclinical validation of AR42, a novel histone deacetylase inhibitor, as treatment for vestibular schwannomas.Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injury.Regulation of the bioavailability of thioredoxin in the lens by a specific thioredoxin-binding protein (TBP-2).Gemcitabine plus CI-994 offers no advantage over gemcitabine alone in the treatment of patients with advanced pancreatic cancer: results of a phase II randomized, double-blind, placebo-controlled, multicenter study.Vorinostat: a new oral histone deacetylase inhibitor approved for cutaneous T-cell lymphoma.Update on the treatment of cutaneous T-cell lymphoma (CTCL): Focus on vorinostat.Tandem ChoRE and CCAAT motifs and associated factors regulate Txnip expression in response to glucose or adenosine-containing moleculesAdenosine-containing molecules amplify glucose signaling and enhance txnip expression.Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors.Histone deacetylase inhibitors: a chemical genetics approach to understanding cellular functions.Oxidative stress by targeted agents promotes cytotoxicity in hematologic malignancies.Vorinostat interferes with the signaling transduction pathway of T-cell receptor and synergizes with phosphoinositide-3 kinase inhibitors in cutaneous T-cell lymphoma.Melding a New 3-Dimensional Agarose Colony Assay with the E(max) Model to Determine the Effects of Drug Combinations on Cancer Cells.
P2860
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P2860
The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin.
description
2002 nî lūn-bûn
@nan
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
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name
The histone deacetylase inhibi ...... and down-regulates thioredoxin
@nl
The histone deacetylase inhibi ...... nd down-regulates thioredoxin.
@ast
The histone deacetylase inhibi ...... nd down-regulates thioredoxin.
@en
type
label
The histone deacetylase inhibi ...... and down-regulates thioredoxin
@nl
The histone deacetylase inhibi ...... nd down-regulates thioredoxin.
@ast
The histone deacetylase inhibi ...... nd down-regulates thioredoxin.
@en
prefLabel
The histone deacetylase inhibi ...... and down-regulates thioredoxin
@nl
The histone deacetylase inhibi ...... nd down-regulates thioredoxin.
@ast
The histone deacetylase inhibi ...... nd down-regulates thioredoxin.
@en
P2093
P2860
P3181
P356
P1476
The histone deacetylase inhibi ...... and down-regulates thioredoxin
@en
P2093
Howard I Scher
Lisa M Butler
Paul A Marks
Richard A Rifkind
Victoria M Richon
Wei-Sheng Xu
P2860
P304
11700-11705
P3181
P356
10.1073/PNAS.182372299
P407
P50
P577
2002-08-20T00:00:00Z