Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome
about
The cell nucleus and aging: tantalizing clues and hopeful promisesEmerin-prelamin A interplay in human fibroblastsLoss of a DNA binding site within the tail of prelamin A contributes to altered heterochromatin anchorage by progerinInhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndromeAge-related changes of nuclear architecture in Caenorhabditis elegansHutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody.Progeria: a rare genetic premature ageing disorderTargeting protein prenylation in progeriaPhenotype and course of Hutchinson-Gilford progeria syndromeBlocking protein farnesylation improves nuclear shape abnormalities in keratinocytes of mice expressing the prelamin A variant in Hutchinson-Gilford progeria syndromeRemodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and agingModel of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromesLamin A-dependent misregulation of adult stem cells associated with accelerated ageingA farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse modelLamin A-dependent nuclear defects in human agingAntisense-mediated exon skipping: a versatile tool with therapeutic and research applicationsModulation of 5' splice site selection using tailed oligonucleotides carrying splicing signals.Spatial Genome Organization and Its Emerging Role as a Potential Diagnosis ToolHallmarks of progeroid syndromes: lessons from mice and reprogrammed cellsSkeletal Muscle Laminopathies: A Review of Clinical and Molecular FeaturesMolecular insights into the premature aging disease progeriaNew approaches to the treatment of orphan genetic disorders: Mitigating molecular pathologies using chemicalsMouse models of laminopathiesNuclear lamins and oxidative stress in cell proliferation and longevityHistone methylation makes its mark on longevityProgress toward therapy with antisense-mediated splicing modulationRecent advances in understanding the role of lamins in health and diseaseThe cell biology of agingLaminopathies and the long strange trip from basic cell biology to therapyHistone methylation: a dynamic mark in health, disease and inheritancePrelamin A farnesylation and progeroid syndromesProgeria of stem cells: stem cell exhaustion in Hutchinson-Gilford progeria syndromeTemsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular PhenotypeLamin b1 polymorphism influences morphology of the nuclear envelope, cell cycle progression, and risk of neural tube defects in miceAgeing-related chromatin defects through loss of the NURD complexInterruption of progerin-lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotypeThe effect of the lamin A and its mutants on nuclear structure, cell proliferation, protein stability, and mobility in embryonic cellsRNA and diseaseThe defective nuclear lamina in Hutchinson-gilford progeria syndrome disrupts the nucleocytoplasmic Ran gradient and inhibits nuclear localization of Ubc9.The alternative heart: impact of alternative splicing in heart disease.
P2860
Q21090227-3BDEC393-248F-430D-AB51-57FC3CC00EC5Q24309728-716D600B-77E9-4EA8-879B-DAA8C85DFED6Q24336480-899B1507-1C96-40B8-A17A-AEFB6B15A900Q24531946-8F17EB4A-E47F-4B3A-BAEF-3E3B46E994BBQ24537685-9ED756EF-0814-4196-B3A3-341CDD222C98Q24541467-CBA38B8B-F9D3-4C37-851F-088EE89FE3ECQ24564144-D4A7EFD5-2590-4C01-9E87-DE9A5A57A31AQ24594564-87B9AB2C-7164-47FB-863F-274F46A6EC97Q24607381-B8B5018E-F687-4439-8F97-5ED4D6B733B4Q24627329-C4136993-EE2B-4E89-A3DA-EFB907E224A5Q24642706-29EE1AFC-0693-48AC-9C6D-66587C54A41FQ24644033-DE3D2A53-0D67-4FD8-8A5B-A40043D99962Q24649634-D1054B18-3E7A-4467-8B98-D508D3943B30Q24657266-F2D63F17-3F83-477F-8BFA-E21980F1E011Q24681309-F39D7226-EFA8-4104-947E-51629977C382Q24682555-749B9DF9-EC9E-4310-B0E5-D761340BD177Q25255627-DB9B5601-9610-4C07-A113-E6796B7D76A9Q26738275-E204ECCC-7DB7-4EE0-96AF-537BA416E1F0Q26740026-5488F744-4D7A-4E2E-8A77-542918B07886Q26741163-D59D0A13-B05C-405F-ABB3-B8F54F3056A5Q26768972-8DB724BB-2D21-43C1-A5F3-9D2CE226B35CQ26801582-509E87D0-B481-421F-B2B0-80584AEAD556Q26829927-EECB6915-F57A-4970-98E5-096453A0655FQ27003105-216EF68D-54C7-490D-9BB0-A6EA3F451532Q27004376-67D87056-8B3F-43C4-8682-52DB4B903422Q27489807-450769E0-5D39-4162-A158-76504952BCAAQ28068068-AD8FD0D4-BFAA-46FA-BD41-5675D538C542Q28088735-CCFBEE30-0549-45A1-AE6F-D472201F3891Q28251294-B5D3276C-B06D-4F67-AB68-DD1BBC92E425Q28263573-B6DA7AA3-E5EE-4F48-B443-D5657657DAA4Q28272957-62F8F6D1-DB1F-4F35-98A1-282B33E61ADFQ28288219-51F855E3-96D4-4D51-80BA-CDAD7E7071CBQ28468499-5607EC5E-610C-44FE-BA5D-8C9C4E5DD240Q28513087-87A22C67-FA18-4C54-868F-F1EA5B091069Q28750018-56CBF830-CDD4-456C-9B43-DE949FA15E3FQ28822028-5D812EBE-8DCA-441F-88B4-4E231F0143B2Q28910340-6EF5A188-E3A3-4843-B5D7-0C56DA8BE229Q29615183-73CC896D-616F-4A4A-B49F-3295798E811BQ30428604-58C7514D-05DF-4CB1-A35A-628F5ECEDF40Q30432053-37292B25-0ECF-41F3-A5BE-FBB755612521
P2860
Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome
description
2005 nî lūn-bûn
@nan
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Reversal of the cellular pheno ...... nson-Gilford progeria syndrome
@ast
Reversal of the cellular pheno ...... nson-Gilford progeria syndrome
@en
Reversal of the cellular pheno ...... nson-Gilford progeria syndrome
@nl
type
label
Reversal of the cellular pheno ...... nson-Gilford progeria syndrome
@ast
Reversal of the cellular pheno ...... nson-Gilford progeria syndrome
@en
Reversal of the cellular pheno ...... nson-Gilford progeria syndrome
@nl
prefLabel
Reversal of the cellular pheno ...... nson-Gilford progeria syndrome
@ast
Reversal of the cellular pheno ...... nson-Gilford progeria syndrome
@en
Reversal of the cellular pheno ...... nson-Gilford progeria syndrome
@nl
P2860
P3181
P356
P1433
P1476
Reversal of the cellular pheno ...... nson-Gilford progeria syndrome
@en
P2093
Paola Scaffidi
Tom Misteli
P2860
P2888
P304
P3181
P356
10.1038/NM1204
P407
P50
P577
2005-03-06T00:00:00Z
P5875
P6179
1045731227