The amyloid-beta precursor protein: integrating structure with biological function - sprookjes - yvandenbroek - TriplyDB

The amyloid-beta precursor protein: integrating structure with biological function

The amyloid-beta precursor protein: integrating structure with biological function

http://www.wikidata.org/entity/Q24540102

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APP binds DR6 to trigger axon pruning and neuron death via distinct caspases Amyloid beta precursor protein and prion protein have a conserved interaction affecting cell adhesion and CNS development FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4 Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein The amyloid precursor protein: beyond amyloid The Alzheimer's peptides Abeta40 and 42 adopt distinct conformations in water: a combined MD / NMR study The Neuroprotective Properties of the Amyloid Precursor Protein Following Traumatic Brain Injury Amyloid precursor protein and amyloid precursor-like protein 2 in cancer Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease Contactin-4 mediates axon-target specificity and functional development of the accessory optic system.Structural aspects and physiological consequences of APP/APLP trans-dimerization.Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function The collagen chaperone HSP47 is a new interactor of APP that affects the levels of extracellular beta-amyloid peptides The in vivo brain interactome of the amyloid precursor protein Fe65 is required for Tip60-directed histone H4 acetylation at DNA strand breaks Increased dendritic spine density and tau expression are associated with individual differences in steroidal regulation of male sexual behavior.APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle.Selective modulation of amyloid-beta peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Abeta levels.Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo.Inhibition of amyloidogenesis by nonsteroidal anti-inflammatory drugs and their hybrid nitrates The secretases: enzymes with therapeutic potential in Alzheimer disease.Amyloid precursor protein (APP)/APP-like protein 2 (APLP2) expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan sulfate Effects of heparin and enoxaparin on APP processing and Aβ production in primary cortical neurons from Tg2576 mice.Modeling presenilin-dependent familial Alzheimer's disease: emphasis on presenilin substrate-mediated signaling and synaptic function.Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.In vitro amyloidogenic peptides of galectin-7: possible mechanism of amyloidogenesis of primary localized cutaneous amyloidosis Brain endothelial cells produce amyloid {beta} from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form A differential association of Apolipoprotein E isoforms with the amyloid-β oligomer in solution.Amyloid-β as a modulator of synaptic plasticity Dysregulation of Ca2+ signaling in astrocytes from mice lacking amyloid precursor protein.Analysis of the overall structure of the multi-domain amyloid precursor protein (APP).ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1 APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability.Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.All in the Family: How the APPs Regulate Neurogenesis N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production.Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains.Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease?Subcellular trafficking of the amyloid precursor protein gene family and its pathogenic role in Alzheimer's disease.Role of amyloid precursor protein, amyloid-beta and gamma-secretase in cholesterol maintenance.

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P2860

The amyloid-beta precursor protein: integrating structure with biological function

http://www.wikidata.org/entity/Q24540102

description

2005 nî lūn-bûn

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2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2005 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

The amyloid-beta precursor protein: integrating structure with biological function

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The amyloid-beta precursor protein: integrating structure with biological function

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The amyloid-beta precursor protein: integrating structure with biological function

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type

label

The amyloid-beta precursor protein: integrating structure with biological function

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The amyloid-beta precursor protein: integrating structure with biological function

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The amyloid-beta precursor protein: integrating structure with biological function

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prefLabel

The amyloid-beta precursor protein: integrating structure with biological function

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The amyloid-beta precursor protein: integrating structure with biological function

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The amyloid-beta precursor protein: integrating structure with biological function

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SJ.EMBOJ.7600860

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The EMBO Journal

P1476

The amyloid-beta precursor protein: integrating structure with biological function

@en

P2093

Bart De Strooper

http://www.w3.org/2001/XMLSchema#string

Constanze Reinhard

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P2860

Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function

Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc

APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein

Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage

Homo- and heterodimerization of APP family members promotes intercellular adhesion.

The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling

Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain

Metals and amyloid-beta in Alzheimer's disease

Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

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3996-4006

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10.1038/SJ.EMBOJ.7600860

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23

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Sébastien S. Hébert

Sébastien S Hébert

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7514777

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16252002

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protein structure

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1356301

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