Functional analysis of mRNA scavenger decapping enzymes. - sprookjes - yvandenbroek - TriplyDB

Functional analysis of mRNA scavenger decapping enzymes.

Functional analysis of mRNA scavenger decapping enzymes.

http://www.wikidata.org/entity/Q24540302

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7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity Metal determines efficiency and substrate specificity of the nuclear NUDIX decapping proteins X29 and H29K (Nudt16)DcpS as a therapeutic target for spinal muscular atrophy.DcpS scavenger decapping enzyme can modulate pre-mRNA splicing Mechanistic and kinetic analysis of the DcpS scavenger decapping enzyme Stress granules and processing bodies are dynamically linked sites of mRNP remodeling A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay Proteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systems Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily Scavenger decapping activity facilitates 5' to 3' mRNA decay Applications of Phosphate Modification and Labeling to Study (m)RNA Caps.Structural requirements for Caenorhabditis elegans DcpS substrates based on fluorescence and HPLC enzyme kinetic studies.Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications.Caenorhabditis elegans decapping proteins: localization and functional analysis of Dcp1, Dcp2, and DcpS during embryogenesis.Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes.Under the Tucson sun: a meeting in the desert on mRNA decay.Differential utilization of decapping enzymes in mammalian mRNA decay pathways.A quantitative assay for measuring mRNA decapping by splinted ligation reverse transcription polymerase chain reaction: qSL-RT-PCR Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex.Modulation of neuritogenesis by a protein implicated in X-linked mental retardation.Delta-lactoferrin, an intracellular lactoferrin isoform that acts as a transcription factor.Potential therapeutic applications of RNA cap analogs.Identification of an mRNA-decapping regulator implicated in X-linked mental retardation.The human decapping scavenger enzyme DcpS modulates microRNA turnover.An excess of catalytically required motions inhibits the scavenger decapping enzyme.mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation Dcp2 Decaps m2,2,7GpppN-capped RNAs, and its activity is sequence and context dependent.Co-transcriptional degradation of aberrant pre-mRNA by Xrn2.Kinetics of C. elegans DcpS cap hydrolysis studied by fluorescence spectroscopy.Analysis of decapping scavenger cap complex using modified cap analogs reveals molecular determinants for efficient cap binding.DCPS scavenges the 7-methylguanosine cap of mRNA Hydrolytic activity of human Nudt16 enzyme on dinucleotide cap analogs and short capped oligonucleotides.Cap analogs containing 6-thioguanosine--reagents for the synthesis of mRNAs selectively photo-crosslinkable with cap-binding biomolecules.

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Functional analysis of mRNA scavenger decapping enzymes.

http://www.wikidata.org/entity/Q24540302

description

2004 nî lūn-bûn

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2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2004 թվականի հուլիսին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Functional analysis of mRNA scavenger decapping enzymes

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Functional analysis of mRNA scavenger decapping enzymes.

@ast

Functional analysis of mRNA scavenger decapping enzymes.

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type

label

Functional analysis of mRNA scavenger decapping enzymes

@nl

Functional analysis of mRNA scavenger decapping enzymes.

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Functional analysis of mRNA scavenger decapping enzymes.

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prefLabel

Functional analysis of mRNA scavenger decapping enzymes

@nl

Functional analysis of mRNA scavenger decapping enzymes.

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Functional analysis of mRNA scavenger decapping enzymes.

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Functional analysis of mRNA scavenger decapping enzymes.

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Christopher D Lima

http://www.w3.org/2001/XMLSchema#string

Hudan Liu

http://www.w3.org/2001/XMLSchema#string

Megerditch Kiledjian

http://www.w3.org/2001/XMLSchema#string

Meigang Gu

http://www.w3.org/2001/XMLSchema#string

Shin-Wu Liu

http://www.w3.org/2001/XMLSchema#string

Xinfu Jiao

http://www.w3.org/2001/XMLSchema#string

P2860

The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases

Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1

Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit

Structure-based analysis of catalysis and substrate definition in the HIT protein family

Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.

Xenopus U8 snoRNA binding protein is a conserved nuclear decapping enzyme

The hDcp2 protein is a mammalian mRNA decapping enzyme

The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.

Functional characterization of the mammalian mRNA decapping enzyme hDcp2

Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures

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10.1261/RNA.7660804

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9

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10

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Megerditch Kiledjian

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2004-07-23T00:00:00Z

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8437027

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1370627

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