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NVP-LDE225, a potent and selective SMOOTHENED antagonist reduces melanoma growth in vitro and in vivoInteraction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signallingTumor suppressor protein VHL inhibits Hedgehog-Gli activation through suppression of Gli1 nuclear localizationPharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease.The function and expansion of the Patched- and Hedgehog-related homologs in C. elegansOxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cellsThe output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteinsA small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injuryArsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effectorHedgehog signaling regulates segment formation in the annelid PlatynereisA small molecule that binds Hedgehog and blocks its signaling in human cellsIt's all in your head: new insights into craniofacial development and deformationSmall-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonistsAgonizing hedgehog.Roughing up Smoothened: chemical modulators of hedgehog signalingThe therapeutic potential of modulators of the Hedgehog-Gli signaling pathwayGorab Is Required for Dermal Condensate Cells to Respond to Hedgehog Signals during Hair Follicle MorphogenesisMolecular targets for the treatment of pancreatic cancer: Clinical and experimental studiesRecent developments in β-cell differentiation of pluripotent stem cells induced by small and large moleculesCooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapyHedgehog signaling pathway in ovarian cancerConserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary SignalingLocalized Smooth Muscle Differentiation Is Essential for Epithelial Bifurcation during Branching Morphogenesis of the Mammalian Lung.IFT27 links the BBSome to IFT for maintenance of the ciliary signaling compartment.Secretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammalsSingle-molecule imaging of Hedgehog pathway protein Smoothened in primary cilia reveals binding events regulated by Patched1Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway ActivationNovel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation.Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signalingStructural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signallingStructural basis for Smoothened receptor modulation and chemoresistance to anticancer drugsA transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastomaStructural basis of Smoothened regulation by its extracellular domainsItraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growthThe SCF ubiquitin ligase: insights into a molecular machinePlants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggabilitySonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothenedA novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse modelA novel PEGylated liposome-encapsulated SANT75 suppresses tumor growth through inhibiting hedgehog signaling pathway
P2860
Q21132689-9223674C-8B21-4D89-ADCD-711B266C4064Q24310715-B5138B9F-E031-49F2-BE69-31DEDA90B5A7Q24315847-DDED2DA7-DF16-474A-92FE-AAA93A84468DQ24339508-9C7BD080-8A6B-486D-BCA8-36BBE8B3A8D1Q24536542-BAB6B7B3-5711-4206-8BBA-1885C727917BQ24544004-74CE0DF2-4B11-47CA-B740-062C66B08BFEQ24605731-C9D4F209-97D3-434F-9E79-824BF717DCACQ24607445-CC4F1021-AC6F-498B-9D9C-16BBFCECD736Q24631549-C2A6C323-F609-42B4-836B-77D65EE63289Q24635368-9AE78E9B-9A45-497E-82EA-BA25185EE507Q24646445-F3E531B5-989F-4740-A37E-619000EFF930Q24675572-F332BB48-8173-4D02-9E31-4D0F1EC7CF0DQ24794838-3F600BC4-6F7E-42C8-B3F8-708C7678FB5BQ24794890-6211427A-943C-426A-A62F-F30B55477FEEQ24794912-94119B84-29A3-46F8-870D-53D9DCCACF1FQ24794932-78D658A3-8E4F-4446-A26B-D6D89D46CEABQ26766281-FB2B4064-E2DF-4B6D-8EE7-1D82AB0550CCQ26774636-DDBC8499-D968-4760-912C-4557CCEDD719Q26825664-93B4AC0C-63F5-41D8-9EF9-FD08F3707C91Q26865136-A94D126D-1770-4938-8735-963BE9B1AC03Q26995487-6A3D6812-8D89-447A-8458-78C11DE785AEQ27310130-D580FDB3-D90A-4B19-B0B1-C2613D4DF61CQ27314520-B4C19BF4-CE95-4EAD-AEAC-C76B6BFCD76CQ27315067-0CB62FDF-D1EA-4E8E-857E-786B7DA6EDFEQ27318194-E6D61BE6-A619-4A02-A715-8C3B5822CF4CQ27321140-8680EE2A-E10D-4795-A75A-AC6D33A79172Q27321217-5FAA45EA-A270-44B5-BB86-7146C73AD2F7Q27334489-6325CA1F-7CB7-4EE4-BA99-8DCBD0D8D50DQ27680483-FFFC7389-1735-4A7A-B57D-8693928DC80BQ27680954-C373A10F-FDA2-418C-B068-9D85A88FE1DAQ27684635-C197FE33-A80F-43CC-9BDB-F8D296F7FC9FQ28000057-7C15C568-21F3-4901-8B0B-6A2F99944FF0Q28236409-0EB93719-CE4D-4740-A8DD-B8E61211E1DCQ28277263-D1CC491C-85A1-4494-A09B-7FF2D41ED34BQ28279473-07F43C1A-F095-4B43-B4E5-0E695C9345ABQ28279993-5556AA8D-C89C-4B5F-880D-4818B251CAE3Q28385642-AEFEC81C-58DF-4550-A238-07C4C5C9CC23Q28478568-83089F9C-EFB6-448A-8E35-4BEADFE27220Q28478580-AAC08086-8467-47BF-93CB-96D2EFBD3E08Q28485870-AC3B897E-2E1E-4431-8FFF-598FAA6BFF3A
P2860
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Small molecule modulation of Smoothened activity
@ast
Small molecule modulation of Smoothened activity
@en
Small molecule modulation of Smoothened activity
@nl
type
label
Small molecule modulation of Smoothened activity
@ast
Small molecule modulation of Smoothened activity
@en
Small molecule modulation of Smoothened activity
@nl
prefLabel
Small molecule modulation of Smoothened activity
@ast
Small molecule modulation of Smoothened activity
@en
Small molecule modulation of Smoothened activity
@nl
P2093
P2860
P3181
P356
P1476
Small molecule modulation of Smoothened activity
@en
P2093
Jussi Taipale
Keith E Young
Philip A Beachy
Tapan Maiti
P2860
P304
P3181
P356
10.1073/PNAS.182542899
P407
P577
2002-10-29T00:00:00Z