Enzyme interactions in heparan sulfate biosynthesis: uronosyl 5-epimerase and 2-O-sulfotransferase interact in vivo - sprookjes - yvandenbroek - TriplyDB

Enzyme interactions in heparan sulfate biosynthesis: uronosyl 5-epimerase and 2-O-sulfotransferase interact in vivo

Enzyme interactions in heparan sulfate biosynthesis: uronosyl 5-epimerase and 2-O-sulfotransferase interact in vivo

http://www.wikidata.org/entity/Q24555107

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Using engineered 2-O-sulfotransferase to determine the activity of heparan sulfate C5-epimerase and its mutants The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivity Pathophysiology of heparan sulphate: many diseases, few drugs Can we produce heparin/heparan sulfate biomimetics using "mother-nature" as the gold standard?Redirecting the substrate specificity of heparan sulfate 2-O-sulfotransferase by structurally guided mutagenesis Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality A synergistic approach to protein crystallization: combination of a fixed-arm carrier with surface entropy reduction.Initiation of the decorin glycosaminoglycan chain in the endoplasmic reticulum-Golgi intermediate compartment.Heparan sulfate biosynthesis: methods for investigation of the heparanosome Investigating the elusive mechanism of glycosaminoglycan biosynthesis.Golgi N-glycosyltransferases form both homo- and heterodimeric enzyme complexes in live cells.Specific sides to multifaceted glycosaminoglycans are observed in embryonic development.Enzymatic redesigning of biologically active heparan sulfate.The stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity.Glycosyltransferase complexes in eukaryotes: long-known, prevalent but still unrecognized.The CMP-sialic acid transporter is localized in the medial-trans Golgi and possesses two specific endoplasmic reticulum export motifs in its carboxyl-terminal cytoplasmic tail.Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.In vivo manipulation of heparan sulfate structure and its effect on Drosophila development Sulfotransferases and sulfated oligosaccharides.Genetic analysis of the heparan modification network in Caenorhabditis elegans Structural and functional study of D-glucuronyl C5-epimerase Hydrogen/deuterium exchange-LC-MS approach to characterize the action of heparan sulfate C5-epimerase.Combinatorial one-pot chemoenzymatic synthesis of heparin.Distinct 3-O-sulfated heparan sulfate modification patterns are required for kal-1-dependent neurite branching in a context-dependent manner in Caenorhabditis elegans.Glycosylation of glycolipids in the Golgi complex.Biological functions of iduronic acid in chondroitin/dermatan sulfate.Association of beta-1,3-N-acetylglucosaminyltransferase 1 and beta-1,4-galactosyltransferase 1, trans-Golgi enzymes involved in coupled poly-N-acetyllactosamine synthesis.Analysis of Drosophila glucuronyl C5-epimerase: implications for developmental roles of heparan sulfate sulfation compensation and 2-O-sulfated glucuronic acid Fibroblast growth factor-based signaling through synthetic heparan sulfate blocks copolymers studied using high cell density three-dimensional cell printing Cellular and molecular biology of glycosphingolipid glycosylation.Golgi glycosylation and human inherited diseases.Heparosan-derived heparan sulfate/heparin-like compounds: one kind of potential therapeutic agents.Proteoglycan synthesis and Golgi organization in polarized epithelial cells.Heparan sulfate biosynthesis: regulation and variability.The role of syndecan-1 in cellular signaling and its effects on heparan sulfate biosynthesis in mesenchymal tumors Growth factor-heparan sulfate "switches" regulating stages of branching morphogenesis.Molecular model of human heparanase with proposed binding mode of a heparan sulfate oligosaccharide and catalytic amino acids.

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Enzyme interactions in heparan sulfate biosynthesis: uronosyl 5-epimerase and 2-O-sulfotransferase interact in vivo

http://www.wikidata.org/entity/Q24555107

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2001 nî lūn-bûn

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2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2001 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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Enzyme interactions in heparan ...... fotransferase interact in vivo

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Enzyme interactions in heparan ...... fotransferase interact in vivo

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Enzyme interactions in heparan ...... fotransferase interact in vivo

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Enzyme interactions in heparan ...... fotransferase interact in vivo

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Enzyme interactions in heparan ...... fotransferase interact in vivo

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Enzyme interactions in heparan ...... fotransferase interact in vivo

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Enzyme interactions in heparan ...... fotransferase interact in vivo

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Enzyme interactions in heparan ...... fotransferase interact in vivo

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Enzyme interactions in heparan ...... fotransferase interact in vivo

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Proceedings of the National Academy of Sciences of the United States of America

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Enzyme interactions in heparan ...... fotransferase interact in vivo

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P2093

B Smith

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J Aikawa

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J D Esko

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K Kimata

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M A Pinhal

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S Olson

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P2860

Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci

The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate

Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II

Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6)

The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate

The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis.

Localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase to the trans-Golgi network

Cell type-dependent variations in the subcellular distribution of alpha-mannosidase I and II

Plaque formation and isolation of pure lines with poliomyelitis viruses

Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase

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12984-9

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4007850

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10.1073/PNAS.241175798

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23

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98

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2001-11-06T00:00:00Z

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11664909

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11687650

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60811

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