Enzyme interactions in heparan sulfate biosynthesis: uronosyl 5-epimerase and 2-O-sulfotransferase interact in vivo
about
Using engineered 2-O-sulfotransferase to determine the activity of heparan sulfate C5-epimerase and its mutantsThe human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathwayGolgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesisTargeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivityPathophysiology of heparan sulphate: many diseases, few drugsCan we produce heparin/heparan sulfate biomimetics using "mother-nature" as the gold standard?Redirecting the substrate specificity of heparan sulfate 2-O-sulfotransferase by structurally guided mutagenesisHeparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfationMice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethalityA synergistic approach to protein crystallization: combination of a fixed-arm carrier with surface entropy reduction.Initiation of the decorin glycosaminoglycan chain in the endoplasmic reticulum-Golgi intermediate compartment.Heparan sulfate biosynthesis: methods for investigation of the heparanosomeInvestigating the elusive mechanism of glycosaminoglycan biosynthesis.Golgi N-glycosyltransferases form both homo- and heterodimeric enzyme complexes in live cells.Specific sides to multifaceted glycosaminoglycans are observed in embryonic development.Enzymatic redesigning of biologically active heparan sulfate.The stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity.Glycosyltransferase complexes in eukaryotes: long-known, prevalent but still unrecognized.The CMP-sialic acid transporter is localized in the medial-trans Golgi and possesses two specific endoplasmic reticulum export motifs in its carboxyl-terminal cytoplasmic tail.Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.In vivo manipulation of heparan sulfate structure and its effect on Drosophila developmentSulfotransferases and sulfated oligosaccharides.Genetic analysis of the heparan modification network in Caenorhabditis elegansStructural and functional study of D-glucuronyl C5-epimeraseHydrogen/deuterium exchange-LC-MS approach to characterize the action of heparan sulfate C5-epimerase.Combinatorial one-pot chemoenzymatic synthesis of heparin.Distinct 3-O-sulfated heparan sulfate modification patterns are required for kal-1-dependent neurite branching in a context-dependent manner in Caenorhabditis elegans.Glycosylation of glycolipids in the Golgi complex.Biological functions of iduronic acid in chondroitin/dermatan sulfate.Association of beta-1,3-N-acetylglucosaminyltransferase 1 and beta-1,4-galactosyltransferase 1, trans-Golgi enzymes involved in coupled poly-N-acetyllactosamine synthesis.Analysis of Drosophila glucuronyl C5-epimerase: implications for developmental roles of heparan sulfate sulfation compensation and 2-O-sulfated glucuronic acidFibroblast growth factor-based signaling through synthetic heparan sulfate blocks copolymers studied using high cell density three-dimensional cell printingCellular and molecular biology of glycosphingolipid glycosylation.Golgi glycosylation and human inherited diseases.Heparosan-derived heparan sulfate/heparin-like compounds: one kind of potential therapeutic agents.Proteoglycan synthesis and Golgi organization in polarized epithelial cells.Heparan sulfate biosynthesis: regulation and variability.The role of syndecan-1 in cellular signaling and its effects on heparan sulfate biosynthesis in mesenchymal tumorsGrowth factor-heparan sulfate "switches" regulating stages of branching morphogenesis.Molecular model of human heparanase with proposed binding mode of a heparan sulfate oligosaccharide and catalytic amino acids.
P2860
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P2860
Enzyme interactions in heparan sulfate biosynthesis: uronosyl 5-epimerase and 2-O-sulfotransferase interact in vivo
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Enzyme interactions in heparan ...... fotransferase interact in vivo
@ast
Enzyme interactions in heparan ...... fotransferase interact in vivo
@en
Enzyme interactions in heparan ...... fotransferase interact in vivo
@nl
type
label
Enzyme interactions in heparan ...... fotransferase interact in vivo
@ast
Enzyme interactions in heparan ...... fotransferase interact in vivo
@en
Enzyme interactions in heparan ...... fotransferase interact in vivo
@nl
prefLabel
Enzyme interactions in heparan ...... fotransferase interact in vivo
@ast
Enzyme interactions in heparan ...... fotransferase interact in vivo
@en
Enzyme interactions in heparan ...... fotransferase interact in vivo
@nl
P2093
P2860
P3181
P356
P1476
Enzyme interactions in heparan ...... fotransferase interact in vivo
@en
P2093
P2860
P304
P3181
P356
10.1073/PNAS.241175798
P407
P577
2001-11-06T00:00:00Z