Allele-specific silencing of mutant Myh6 transcripts in mice suppresses hypertrophic cardiomyopathy - sprookjes - yvandenbroek - TriplyDB

Allele-specific silencing of mutant Myh6 transcripts in mice suppresses hypertrophic cardiomyopathy

Allele-specific silencing of mutant Myh6 transcripts in mice suppresses hypertrophic cardiomyopathy

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Cell biology of sarcomeric protein engineering: disease modeling and therapeutic potential Targets for therapy in sarcomeric cardiomyopathies Research priorities in sarcomeric cardiomyopathies Clinical and Mechanistic Insights Into the Genetics of Cardiomyopathy Mybpc3 gene therapy for neonatal cardiomyopathy enables long-term disease prevention in mice Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy.Construction of microRNA and transcription factor regulatory network based on gene expression data in cardiomyopathy EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent.Increased Postnatal Cardiac Hyperplasia Precedes Cardiomyocyte Hypertrophy in a Model of Hypertrophic Cardiomyopathy.β-Myosin heavy chain variant Val606Met causes very mild hypertrophic cardiomyopathy in mice, but exacerbates HCM phenotypes in mice carrying other HCM mutations Sarcomere mutation-specific expression patterns in human hypertrophic cardiomyopathy Genetic advances in sarcomeric cardiomyopathies: state of the art.Reprogramming for cardiac regeneration.Developmental stage determines efficiency of gene transfer to muscle satellite cells by in utero delivery of adeno-associated virus vector serotype 2/9 INHERIT (INHibition of the renin angiotensin system in hypertrophic cardiomyopathy and the Effect on hypertrophy-a Randomised Intervention Trial with losartan)Trbp regulates heart function through microRNA-mediated Sox6 repression.A roadmap to investigate the genetic basis of bicuspid aortic valve and its complications: insights from the International BAVCon (Bicuspid Aortic Valve Consortium).Cardiac myosin binding protein C regulates postnatal myocyte cytokinesis.MYBPC3's alternate ending: consequences and therapeutic implications of a highly prevalent 25 bp deletion mutation Alterations in sarcomere function modify the hyperplastic to hypertrophic transition phase of mammalian cardiomyocyte development.Decade in review--cardiomyopathies: Cardiomyopathy on the move.The genetic landscape of cardiomyopathy and its role in heart failure.Preventing pediatric cardiomyopathy: a 2015 outlook.Genetics and Genomics of Single-Gene Cardiovascular Diseases: Common Hereditary Cardiomyopathies as Prototypes of Single-Gene Disorders.Cardiac gene therapy with adeno-associated virus-based vectors.Genome Editing for the Study of Cardiovascular Diseases.Genetics of paediatric cardiomyopathies.Evaluation of MYBPC3 trans-Splicing and Gene Replacement as Therapeutic Options in Human iPSC-Derived Cardiomyocytes.Preparation of rAAV9 to Overexpress or Knockdown Genes in Mouse Hearts.AAV9 Delivery of shRNA to the Mouse Heart.Genome-wide association study and biological pathway analysis of the Eimeria maxima response in broilers.ASPsiRNA: A Resource of ASP-siRNAs Having Therapeutic Potential for Human Genetic Disorders and Algorithm for Prediction of Their Inhibitory Efficacy.Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival.Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy.Hypothesis and theory: mechanical instabilities and non-uniformities in hereditary sarcomere myopathies.A map of human circular RNAs in clinically relevant tissues.Genome Editing: The Recent History and Perspective in Cardiovascular Diseases.Intrinsic MYH7 expression regulation contributes to tissue level allelic imbalance in hypertrophic cardiomyopathy.Allele-specific silencing therapy for Dynamin 2-related dominant centronuclear myopathy.Enlightening the Association between Bicuspid Aortic Valve and Aortopathy.

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Allele-specific silencing of mutant Myh6 transcripts in mice suppresses hypertrophic cardiomyopathy

http://www.wikidata.org/entity/Q24562178

description

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2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2013 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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name

Allele-specific silencing of m ...... es hypertrophic cardiomyopathy

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Allele-specific silencing of m ...... es hypertrophic cardiomyopathy

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Allele-specific silencing of m ...... es hypertrophic cardiomyopathy

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Allele-specific silencing of m ...... es hypertrophic cardiomyopathy

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Allele-specific silencing of m ...... es hypertrophic cardiomyopathy

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Allele-specific silencing of m ...... es hypertrophic cardiomyopathy

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prefLabel

Allele-specific silencing of m ...... es hypertrophic cardiomyopathy

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Allele-specific silencing of m ...... es hypertrophic cardiomyopathy

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Allele-specific silencing of m ...... es hypertrophic cardiomyopathy

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Allele-specific silencing of m ...... es hypertrophic cardiomyopathy

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Christine E Seidman

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Hiroko Wakimoto

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J G Seidman

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P2860

Construction of normalized RNA-seq libraries for next-generation sequencing using the crab duplex-specific nuclease

Single-molecule mechanics of R403Q cardiac myosin isolated from the mouse model of familial hypertrophic cardiomyopathy

The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms

A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation

A mouse model of familial hypertrophic cardiomyopathy

Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart

The Genetic Basis for Cardiomyopathy

Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution.

Polony multiplex analysis of gene expression (PMAGE) in mouse hypertrophic cardiomyopathy.

Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat.

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