Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase
about
The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteinsRegulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPKAntiviral actions of interferonsCytoplasmic p53 polypeptide is associated with ribosomesControl of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation.Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKRCGG Repeats in the 5'UTR of FMR1 RNA Regulate Translation of Other RNAs Localized in the Same RNA GranulesMechanism of interferon action: identification of essential positions within the novel 15-base-pair KCS element required for transcriptional activation of the RNA-dependent protein kinase pkr geneDouble-stranded RNA-independent dimerization of interferon-induced protein kinase PKR and inhibition of dimerization by the cellular P58IPK inhibitor.Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/Caspase-8 death signaling pathwayTranslational control of viral gene expression in eukaryotesAutophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2Heterologous dimerization domains functionally substitute for the double-stranded RNA binding domains of the kinase PKR.2-aminopurine enhances the oncolytic activity of an E1b-deleted adenovirus in hepatocellular carcinoma cells.Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors.dsRNA sensors and plasmacytoid dendritic cells in host defense and autoimmunity.The 58-kilodalton inhibitor of the interferon-induced double-stranded RNA-activated protein kinase is a tetratricopeptide repeat protein with oncogenic properties.Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinaseMechanism of interferon action: characterization of the intermolecular autophosphorylation of PKR, the interferon-inducible, RNA-dependent protein kinase.Protein kinase PKR catalytic activity is required for the PKR-dependent activation of mitogen-activated protein kinases and amplification of interferon beta induction following virus infection.Activation of the double-stranded RNA (dsRNA)-activated human protein kinase in vivo in the absence of its dsRNA binding domain.Novel cell type-specific antiviral mechanism of interferon gamma action in macrophagesDisruption of cellular translational control by a viral truncated eukaryotic translation initiation factor 2alpha kinase homolog.Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation.Structural requirements for double-stranded RNA binding, dimerization, and activation of the human eIF-2 alpha kinase DAI in Saccharomyces cerevisiae.Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha.Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKRTolerogenic and activatory plasmacytoid dendritic cells in autoimmunity.The kinase activity of PKR represses inflammasome activity.RNA-dependent protein kinase PKR and the Z-DNA binding orthologue PKZ differ in their capacity to mediate initiation factor eIF2α-dependent inhibition of protein synthesis and virus-induced stress granule formation.Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspasesTranslation of intronless RNAs is strongly stimulated by the Epstein-Barr virus mRNA export factor EB2.Variola virus E3L Zα domain, but not its Z-DNA binding activity, is required for PKR inhibitionMutations in GCD11, the structural gene for eIF-2 gamma in yeast, alter translational regulation of GCN4 and the selection of the start site for protein synthesis.Double-stranded (ds) RNA binding and not dimerization correlates with the activation of the dsRNA-dependent protein kinase (PKR).The African swine fever virus DP71L protein recruits the protein phosphatase 1 catalytic subunit to dephosphorylate eIF2alpha and inhibits CHOP induction but is dispensable for these activities during virus infection.Mechanism of Protein Kinase R Inhibition by Human Cytomegalovirus pTRS1.Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR: role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2).Potential Alu function: regulation of the activity of double-stranded RNA-activated kinase PKR.The interferon system: a review with emphasis on the role of PKR in growth control.
P2860
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P2860
Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase
description
1993 nî lūn-bûn
@nan
1993 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Translational regulation by th ...... ctivated 68-kDa protein kinase
@ast
Translational regulation by th ...... ctivated 68-kDa protein kinase
@en
Translational regulation by th ...... ctivated 68-kDa protein kinase
@nl
type
label
Translational regulation by th ...... ctivated 68-kDa protein kinase
@ast
Translational regulation by th ...... ctivated 68-kDa protein kinase
@en
Translational regulation by th ...... ctivated 68-kDa protein kinase
@nl
prefLabel
Translational regulation by th ...... ctivated 68-kDa protein kinase
@ast
Translational regulation by th ...... ctivated 68-kDa protein kinase
@en
Translational regulation by th ...... ctivated 68-kDa protein kinase
@nl
P2093
P2860
P356
P1476
Translational regulation by th ...... ctivated 68-kDa protein kinase
@en
P2093
A G Hinnebusch
G N Barber
P2860
P304
P356
10.1073/PNAS.90.10.4621
P407
P50
P577
1993-05-15T00:00:00Z