Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase - sprookjes - yvandenbroek - TriplyDB

Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase

Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase

http://www.wikidata.org/entity/Q24562903

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The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK Antiviral actions of interferons Cytoplasmic p53 polypeptide is associated with ribosomes Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation.Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR CGG Repeats in the 5'UTR of FMR1 RNA Regulate Translation of Other RNAs Localized in the Same RNA Granules Mechanism of interferon action: identification of essential positions within the novel 15-base-pair KCS element required for transcriptional activation of the RNA-dependent protein kinase pkr gene Double-stranded RNA-independent dimerization of interferon-induced protein kinase PKR and inhibition of dimerization by the cellular P58IPK inhibitor.Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/Caspase-8 death signaling pathway Translational control of viral gene expression in eukaryotes Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2 Heterologous dimerization domains functionally substitute for the double-stranded RNA binding domains of the kinase PKR.2-aminopurine enhances the oncolytic activity of an E1b-deleted adenovirus in hepatocellular carcinoma cells.Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors.dsRNA sensors and plasmacytoid dendritic cells in host defense and autoimmunity.The 58-kilodalton inhibitor of the interferon-induced double-stranded RNA-activated protein kinase is a tetratricopeptide repeat protein with oncogenic properties.Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase Mechanism of interferon action: characterization of the intermolecular autophosphorylation of PKR, the interferon-inducible, RNA-dependent protein kinase.Protein kinase PKR catalytic activity is required for the PKR-dependent activation of mitogen-activated protein kinases and amplification of interferon beta induction following virus infection.Activation of the double-stranded RNA (dsRNA)-activated human protein kinase in vivo in the absence of its dsRNA binding domain.Novel cell type-specific antiviral mechanism of interferon gamma action in macrophages Disruption of cellular translational control by a viral truncated eukaryotic translation initiation factor 2alpha kinase homolog.Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation.Structural requirements for double-stranded RNA binding, dimerization, and activation of the human eIF-2 alpha kinase DAI in Saccharomyces cerevisiae.Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha.Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKR Tolerogenic and activatory plasmacytoid dendritic cells in autoimmunity.The kinase activity of PKR represses inflammasome activity.RNA-dependent protein kinase PKR and the Z-DNA binding orthologue PKZ differ in their capacity to mediate initiation factor eIF2α-dependent inhibition of protein synthesis and virus-induced stress granule formation.Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases Translation of intronless RNAs is strongly stimulated by the Epstein-Barr virus mRNA export factor EB2.Variola virus E3L Zα domain, but not its Z-DNA binding activity, is required for PKR inhibition Mutations in GCD11, the structural gene for eIF-2 gamma in yeast, alter translational regulation of GCN4 and the selection of the start site for protein synthesis.Double-stranded (ds) RNA binding and not dimerization correlates with the activation of the dsRNA-dependent protein kinase (PKR).The African swine fever virus DP71L protein recruits the protein phosphatase 1 catalytic subunit to dephosphorylate eIF2alpha and inhibits CHOP induction but is dispensable for these activities during virus infection.Mechanism of Protein Kinase R Inhibition by Human Cytomegalovirus pTRS1.Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR: role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2).Potential Alu function: regulation of the activity of double-stranded RNA-activated kinase PKR.The interferon system: a review with emphasis on the role of PKR in growth control.

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P2860

Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase

http://www.wikidata.org/entity/Q24562903

description

1993 nî lūn-bûn

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1993 թուականի Մայիսին հրատարակուած գիտական յօդուած

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1993 թվականի մայիսին հրատարակված գիտական հոդված

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1993年の論文

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1993年論文

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1993年論文

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1993年論文

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1993年論文

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1993年論文

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1993年论文

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name

Translational regulation by th ...... ctivated 68-kDa protein kinase

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Translational regulation by th ...... ctivated 68-kDa protein kinase

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Translational regulation by th ...... ctivated 68-kDa protein kinase

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Translational regulation by th ...... ctivated 68-kDa protein kinase

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Proceedings of the National Academy of Sciences of the United States of America

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Translational regulation by th ...... ctivated 68-kDa protein kinase

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A G Hinnebusch

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G N Barber

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M G Katze

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M L Wong

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M Wambach

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P2860

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase

Mechanism and regulation of eukaryotic protein synthesis

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast.

Mechanism of interferon action: identification of a RNA binding domain within the N-terminal region of the human RNA-dependent P1/eIF-2 alpha protein kinase

Translational control in mammalian cells

Use of eukaryotic expression technology in the functional analysis of cloned genes

Detection of activated double-stranded RNA-dependent protein kinase in 3T3-F442A cells.

Purification and partial characterization of a cellular inhibitor of the interferon-induced protein kinase of Mr 68,000 from influenza virus-infected cells.

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10

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90

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46564

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