Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development - sprookjes - yvandenbroek - TriplyDB

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

http://www.wikidata.org/entity/Q24563399

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Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways S6K1 plays a critical role in early adipocyte differentiation An emerging role for TOR signaling in mammalian tissue and stem cell physiology Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy mTOR: from growth signal integration to cancer, diabetes and ageing Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine mTOR signaling in growth control and disease Rapamycin and mTOR kinase inhibitors Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR Stem cell guidance through the mechanistic target of rapamycin Autophagy and the (Pro)renin Receptor Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin Driving neural regeneration through the mammalian target of rapamycin Modeling anterior development in mice: diet as modulator of risk for neural tube defects Spatiotemporal characterization of mTOR kinase activity following kainic acid induced status epilepticus and analysis of rat brain response to chronic rapamycin treatment Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians Left-right asymmetry in the light of TOR: An update on what we know so far mTOR signaling in tumorigenesis Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks Excessive Leucine-mTORC1-Signalling of Cow Milk-Based Infant Formula: The Missing Link to Understand Early Childhood Obesity Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression Teaching the basics of autophagy and mitophagy to redox biologists--mechanisms and experimental approaches Phosphoproteome of human glioblastoma initiating cells reveals novel signaling regulators encoded by the transcriptome Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives Placental Origins of Chronic Disease.Leucine and arginine regulate trophoblast motility through mTOR-dependent and independent pathways in the preimplantation mouse embryo Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage.Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production.Role of mTOR in podocyte function and diabetic nephropathy in humans and mice.PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.A kinase-dead knock-in mutation in mTOR leads to early embryonic lethality and is dispensable for the immune system in heterozygous mice.Inhibition of S6K by resveratrol: in search of the purpose Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy.Prediction of blastocyst development and implantation potential in utero based on the third cleavage and compaction times in mouse pre-implantation embryos.RagA, but not RagB, is essential for embryonic development and adult mice.Mice endometrium receptivity in early pregnancy is impaired by maternal hyperinsulinemia.A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

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P2860

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

http://www.wikidata.org/entity/Q24563399

description

2004 nî lūn-bûn

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2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2004 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2004年の論文

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2004年学术文章

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2004年學術文章

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Disruption of the mouse mTOR g ...... mbryonic stem cell development

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Disruption of the mouse mTOR g ...... mbryonic stem cell development

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Disruption of the mouse mTOR g ...... mbryonic stem cell development

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Disruption of the mouse mTOR g ...... mbryonic stem cell development

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Disruption of the mouse mTOR g ...... mbryonic stem cell development

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Disruption of the mouse mTOR g ...... mbryonic stem cell development

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Disruption of the mouse mTOR g ...... mbryonic stem cell development

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Disruption of the mouse mTOR g ...... mbryonic stem cell development

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Disruption of the mouse mTOR g ...... mbryonic stem cell development

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MCB.24.21.9508-9516.2004

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Molecular and Cellular Biology

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Disruption of the mouse mTOR g ...... mbryonic stem cell development

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Eric J Brown

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Jean-Francois Spetz

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Matthias Mueller

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Melanie Sticker

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Sara C Kozma

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Silvia Cereghini

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Stephen G Dann

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Sung Hee Um

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P2860

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints.

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10.1128/MCB.24.21.9508-9516.2004

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Yann-Gaël Gangloff

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