Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest - sprookjes - yvandenbroek - TriplyDB

Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest

Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest

http://www.wikidata.org/entity/Q24563429

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p53-dependent ceramide response to genotoxic stress Roles of bioactive sphingolipids in cancer biology and therapeutics A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death Ceramide dissociates 3'-phosphoinositide production from pleckstrin homology domain translocation Cell cycle arrest of hematopoietic cell lines after treatment with ceramide is commonly associated with retinoblastoma activation.Modulation of ceramide content and lack of apoptosis in the chronically hypoxic neonatal rat heart.Apoptosis and the activity of ceramide, Bax and Bcl-2 in the lungs of neonatal rats exposed to limited and prolonged hyperoxia.The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis.2'-hydroxy C16-ceramide induces apoptosis-associated proteomic changes in C6 glioma cells.Age-dependent changes in the sphingolipid composition of mouse CD4+ T cell membranes and immune synapses implicate glucosylceramides in age-related T cell dysfunction Cancer treatment strategies targeting sphingolipid metabolism.The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death Autophagy in the light of sphingolipid metabolism Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells.Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway Sphingolipids in cancer: regulation of pathogenesis and therapy.Ceramide and neurodegeneration: susceptibility of neurons and oligodendrocytes to cell damage and death.Asymmetric dimethylarginine attenuates serum starvation-induced apoptosis via suppression of the Fas (APO-1/CD95)/JNK (SAPK) pathway.Bcl-2 interrupts the ceramide-mediated pathway of cell death.Therapeutic applications of bioactive sphingolipids in hematological malignancies.Ceramide function in the brain: when a slight tilt is enough.p53 and Ceramide as Collaborators in the Stress Response Sphingolipids: key regulators of apoptosis and pivotal players in cancer drug resistance Sphingolipids in the DNA damage response.Sphingosine-1-phosphate metabolism: A structural perspective.Sphingolipids in mitochondria.Sphingolipid metabolism is a crucial determinant of cellular fate in nonstimulated proliferating Madin-Darby canine kidney (MDCK) cells.Human Bak induces cell death in Schizosaccharomyces pombe with morphological changes similar to those with apoptosis in mammalian cells.Ceramide-induced G2 arrest in rhabdomyosarcoma (RMS) cells requires p21Cip1/Waf1 induction and is prevented by MDM2 overexpression.Human T-cell lymphotropic virus type I-transformed T-cells have a partial defect in ceramide synthesis in response to N-(4-hydroxyphenyl)retinamide Efficacy and mechanism of action of the proteasome inhibitor PS-341 in T-cell lymphomas and HTLV-I associated adult T-cell leukemia/lymphoma.Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action.Decreased activity and enhanced nuclear export of CCAAT-enhancer-binding protein beta during inhibition of adipogenesis by ceramide.Ceramide inhibits PKCθ by regulating its phosphorylation and translocation to lipid rafts in Jurkat cells.Production of ceramides causes apoptosis during early neural differentiation in vitro.Ceramide-induced cell death is independent of the Fas/Fas ligand pathway and is prevented by Nur77 overexpression in A20 B cells.Aryl hydrocarbon receptor regulation of ceramide-induced apoptosis in murine hepatoma 1c1c7 cells. A function independent of aryl hydrocarbon receptor nuclear translocator.Role of ceramide in lipopolysaccharide (LPS)-induced signaling. LPS increases ceramide rather than acting as a structural homolog.Cell-cycle-dependent changes in ceramide levels preceding retinoblastoma protein dephosphorylation in G2/M.Activation of acid sphingomyelinase by interleukin-1 (IL-1) requires the IL-1 receptor accessory protein.

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Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest

http://www.wikidata.org/entity/Q24563429

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1995 nî lūn-bûn

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1995 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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1995年の論文

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Proceedings of the National Academy of Sciences of the United States of America

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Retinoblastoma gene product as ...... ndent pathway of growth arrest

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P2093

G S Dbaibo

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J K Schwarz

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J M Horowitz

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L M Obeid

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P2860

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

Improved retroviral vectors for gene transfer and expression.

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

Some retinoblastomas, osteosarcomas, and soft tissue sarcomas may share a common etiology.

Abnormalities in structure and expression of the human retinoblastoma gene in SCLC.

Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein.

The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle.

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1347-51

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10.1073/PNAS.92.5.1347

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5

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92

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